Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: Integration of the glutamate/GABA-glutamine cycle
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Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease : Integration of the glutamate/GABA-glutamine cycle. / Andersen, Jens V.; Schousboe, Arne; Verkhratsky, Alexei.
In: Progress in Neurobiology, Vol. 217, 102331, 2022.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease
T2 - Integration of the glutamate/GABA-glutamine cycle
AU - Andersen, Jens V.
AU - Schousboe, Arne
AU - Verkhratsky, Alexei
N1 - Funding Information: JVA gratefully acknowledges The Scholarship of Peter & Emma Thomsen (Denmark).
PY - 2022
Y1 - 2022
N2 - Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD). Neurons and astrocytes function in close collaboration through neurotransmitter recycling, collectively known as the glutamate/GABA-glutamine cycle, which is essential to sustain neurotransmission. Neurotransmitter recycling is intimately linked to astrocyte energy metabolism. In the course of AD, astrocytes undergo extensive metabolic remodeling, which may profoundly affect the glutamate/GABA-glutamine cycle. The consequences of altered astrocyte function and metabolism in relation to neurotransmitter recycling are yet to be comprehended. Metabolic alterations of astrocytes in AD deprive neurons of metabolic support, thereby contributing to synaptic dysfunction and neurodegeneration. In addition, several astrocyte-specific components of the glutamate/GABA-glutamine cycle, including glutamine synthesis and synaptic neurotransmitter uptake, are perturbed in AD. Integration of the complex astrocyte biology within the context of AD is essential for understanding the fundamental mechanisms of the disease, while restoring astrocyte metabolism may serve as an approach to arrest or even revert clinical progression of AD.
AB - Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD). Neurons and astrocytes function in close collaboration through neurotransmitter recycling, collectively known as the glutamate/GABA-glutamine cycle, which is essential to sustain neurotransmission. Neurotransmitter recycling is intimately linked to astrocyte energy metabolism. In the course of AD, astrocytes undergo extensive metabolic remodeling, which may profoundly affect the glutamate/GABA-glutamine cycle. The consequences of altered astrocyte function and metabolism in relation to neurotransmitter recycling are yet to be comprehended. Metabolic alterations of astrocytes in AD deprive neurons of metabolic support, thereby contributing to synaptic dysfunction and neurodegeneration. In addition, several astrocyte-specific components of the glutamate/GABA-glutamine cycle, including glutamine synthesis and synaptic neurotransmitter uptake, are perturbed in AD. Integration of the complex astrocyte biology within the context of AD is essential for understanding the fundamental mechanisms of the disease, while restoring astrocyte metabolism may serve as an approach to arrest or even revert clinical progression of AD.
KW - Alternative substrates
KW - Astrogliosis
KW - Dementia
KW - Excitotoxicity
KW - Mitochondria
KW - Neurodegeneration
KW - Neurotransmitter recycling
U2 - 10.1016/j.pneurobio.2022.102331
DO - 10.1016/j.pneurobio.2022.102331
M3 - Review
C2 - 35872221
AN - SCOPUS:85135684171
VL - 217
JO - Progress in Neurobiology
JF - Progress in Neurobiology
SN - 0301-0082
M1 - 102331
ER -
ID: 318206027