Astrocytes take the stage in a tale of signaling-metabolism coupling
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Astrocytes take the stage in a tale of signaling-metabolism coupling. / Bak, Lasse K.
In: The Journal of Biological Chemistry, Vol. 292, No. 22, 02.06.2017, p. 9439-9440.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Astrocytes take the stage in a tale of signaling-metabolism coupling
AU - Bak, Lasse K
N1 - © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.
PY - 2017/6/2
Y1 - 2017/6/2
N2 - Astrocytes are crucial cells in the brain that are intimately coupled with neuronal metabolism. A new paper from San Martín et al. provides evidence that physiological levels of the gaseous signal molecule NO can rapidly and reversibly increase astrocyte metabolism of glucose and production of lactate. A proposed neurological coupling-from the potential source of NO, endothelial cells, to the potential beneficiary from the lactate, neurons-prompts new questions regarding the controversial role of lactate in the brain.
AB - Astrocytes are crucial cells in the brain that are intimately coupled with neuronal metabolism. A new paper from San Martín et al. provides evidence that physiological levels of the gaseous signal molecule NO can rapidly and reversibly increase astrocyte metabolism of glucose and production of lactate. A proposed neurological coupling-from the potential source of NO, endothelial cells, to the potential beneficiary from the lactate, neurons-prompts new questions regarding the controversial role of lactate in the brain.
KW - Journal Article
U2 - 10.1074/jbc.H117.777243
DO - 10.1074/jbc.H117.777243
M3 - Journal article
C2 - 28576887
VL - 292
SP - 9439
EP - 9440
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 22
ER -
ID: 178986469