Astrocytic abnormalities in schizophrenia
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Astrocytic abnormalities in schizophrenia. / Saleki, Kiarash; Banazadeh, Mohammad; Abadi, Banafshe; Pirmoradi, Zeynab; Esmaili, Zahra; Amiri, Shiva ; Pourahmad, Ramtin; Kohlmeier, Kristi Anne; Shabani, Mohammad.
Neurophysiology. ed. / Thomas Heinbockel. In Tech Open Access, 2022.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Astrocytic abnormalities in schizophrenia
AU - Saleki, Kiarash
AU - Banazadeh, Mohammad
AU - Abadi, Banafshe
AU - Pirmoradi, Zeynab
AU - Esmaili, Zahra
AU - Amiri, Shiva
AU - Pourahmad, Ramtin
AU - Kohlmeier, Kristi Anne
AU - Shabani, Mohammad
PY - 2022
Y1 - 2022
N2 - AbstractAstrocytes are glial cells in the central nervous system (CNS), which contribute to CNS health and disease by participating in homeostatic, structural, and metabolic processes that play an essential role in facilitating synaptic transmission between neurons. Schizophrenia (SCZ) is a neuropsychiatric disorder associated with various positive and negative behaviors and interruption of executive function and cognition thought to be due partly to aberrations in signaling within neural networks. Recent research has demonstrated that astrocytes play a role in SCZ through various effects, including influencing immune system function, altering white matter, and mediating changes in neurotransmitters. Astrocytes are also known to play a role in inducing SCZ-associated changes in neuroplasticity, which includes alterations in synaptic strength and neurogenesis. Also, astrocyte abnormalities are linked to neurobehavioral impairments seen at the clinical level. The present chapter details general information on SCZ. It highlights the role of astrocytes in SCZ at molecular and behavioral levels, including neural changes seen in the disease, and the therapeutic implications of targeting astrocytes in SCZ.
AB - AbstractAstrocytes are glial cells in the central nervous system (CNS), which contribute to CNS health and disease by participating in homeostatic, structural, and metabolic processes that play an essential role in facilitating synaptic transmission between neurons. Schizophrenia (SCZ) is a neuropsychiatric disorder associated with various positive and negative behaviors and interruption of executive function and cognition thought to be due partly to aberrations in signaling within neural networks. Recent research has demonstrated that astrocytes play a role in SCZ through various effects, including influencing immune system function, altering white matter, and mediating changes in neurotransmitters. Astrocytes are also known to play a role in inducing SCZ-associated changes in neuroplasticity, which includes alterations in synaptic strength and neurogenesis. Also, astrocyte abnormalities are linked to neurobehavioral impairments seen at the clinical level. The present chapter details general information on SCZ. It highlights the role of astrocytes in SCZ at molecular and behavioral levels, including neural changes seen in the disease, and the therapeutic implications of targeting astrocytes in SCZ.
U2 - 10.5772/intechopen.106618
DO - 10.5772/intechopen.106618
M3 - Book chapter
BT - Neurophysiology
A2 - Heinbockel, Thomas
PB - In Tech Open Access
ER -
ID: 314160717