Biglycan deficiency interferes with ovariectomy-induced bone loss

Research output: Contribution to journal › Journal article › Research › peer-review

  • Karina L Nielsen
  • Matthew R Allen
  • Susan A Bloomfield
  • Thomas L Andersen
  • Xiao-Dong Chen
  • Hans S Poulsen
  • Marian F Young
  • Heegaard, Anne-Marie
Biglycan is a matrix proteoglycan with a possible role in bone turnover. In a 4-week study with sham-operated or OVX biglycan-deficient or wildtype mice, we show that biglycan-deficient mice are resistant to OVX-induced trabecular bone loss and that there is a gender difference in the response to biglycan deficiency.
Original languageEnglish
JournalJournal of Bone and Mineral Research
Volume18
Issue number12
Pages (from-to)2152-8
Number of pages7
ISSN0884-0431
DOIs
Publication statusPublished - 2003

    Research areas

  • Animals, Biglycan, Bone Density, Carrier Proteins, Extracellular Matrix Proteins, Female, Glycoproteins, Male, Membrane Glycoproteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Animal, Osteoclasts, Osteoporosis, Osteoprotegerin, Ovariectomy, Proteoglycans, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Receptors, Cytoplasmic and Nuclear, Receptors, Tumor Necrosis Factor

ID: 38426449