Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo. / Poulie, Christian B.M.; Sporer, Emanuel; Hvass, Lars; Jørgensen, Jesper T.; Kempen, Paul J.; Lopes van den Broek, Sara I.; Shalgunov, Vladimir; Kjaer, Andreas; Jensen, Andreas I.; Herth, Matthias M.

In: Chemistry - A European Journal, Vol. 28, No. 61, e202201847, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulie, CBM, Sporer, E, Hvass, L, Jørgensen, JT, Kempen, PJ, Lopes van den Broek, SI, Shalgunov, V, Kjaer, A, Jensen, AI & Herth, MM 2022, 'Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo', Chemistry - A European Journal, vol. 28, no. 61, e202201847. https://doi.org/10.1002/chem.202201847

APA

Poulie, C. B. M., Sporer, E., Hvass, L., Jørgensen, J. T., Kempen, P. J., Lopes van den Broek, S. I., Shalgunov, V., Kjaer, A., Jensen, A. I., & Herth, M. M. (2022). Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo. Chemistry - A European Journal, 28(61), [e202201847]. https://doi.org/10.1002/chem.202201847

Vancouver

Poulie CBM, Sporer E, Hvass L, Jørgensen JT, Kempen PJ, Lopes van den Broek SI et al. Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo. Chemistry - A European Journal. 2022;28(61). e202201847. https://doi.org/10.1002/chem.202201847

Author

Poulie, Christian B.M. ; Sporer, Emanuel ; Hvass, Lars ; Jørgensen, Jesper T. ; Kempen, Paul J. ; Lopes van den Broek, Sara I. ; Shalgunov, Vladimir ; Kjaer, Andreas ; Jensen, Andreas I. ; Herth, Matthias M. / Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo. In: Chemistry - A European Journal. 2022 ; Vol. 28, No. 61.

Bibtex

@article{41ae445594574db1a14f02bc4c2ca192,
title = "Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo",
abstract = "Combining nanotechnology and bioorthogonal chemistry for theranostic strategies offers the possibility to develop next generation nanomedicines. These materials are thought to increase therapeutic outcome and improve current cancer management. Due to their size, nanomedicines target tumors passively. Thus, they can be used for drug delivery purposes. Bioorthogonal chemistry allows for a pretargeting approach. Higher target-to-background drug accumulation ratios can be achieved. Pretargeting can also be used to induce internalization processes or trigger controlled drug release. Colloidal gold nanoparticles (AuNPs) have attracted widespread interest as drug delivery vectors within the last decades. Here, we demonstrate for the first time the possibility to successfully ligate AuNPs in vivo to pretargeted monoclonal antibodies. We believe that this possibility will facilitate the development of AuNPs for clinical use and ultimately, improve state-of-the-art patient care.",
keywords = "bioorthogonal chemistry, click chemistry, gold nanoparticles, pretargeting, tetrazine ligation",
author = "Poulie, {Christian B.M.} and Emanuel Sporer and Lars Hvass and J{\o}rgensen, {Jesper T.} and Kempen, {Paul J.} and {Lopes van den Broek}, {Sara I.} and Vladimir Shalgunov and Andreas Kjaer and Jensen, {Andreas I.} and Herth, {Matthias M.}",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.",
year = "2022",
doi = "10.1002/chem.202201847",
language = "English",
volume = "28",
journal = "Chemistry: A European Journal",
issn = "0947-6539",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "61",

}

RIS

TY - JOUR

T1 - Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo

AU - Poulie, Christian B.M.

AU - Sporer, Emanuel

AU - Hvass, Lars

AU - Jørgensen, Jesper T.

AU - Kempen, Paul J.

AU - Lopes van den Broek, Sara I.

AU - Shalgunov, Vladimir

AU - Kjaer, Andreas

AU - Jensen, Andreas I.

AU - Herth, Matthias M.

N1 - Publisher Copyright: © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.

PY - 2022

Y1 - 2022

N2 - Combining nanotechnology and bioorthogonal chemistry for theranostic strategies offers the possibility to develop next generation nanomedicines. These materials are thought to increase therapeutic outcome and improve current cancer management. Due to their size, nanomedicines target tumors passively. Thus, they can be used for drug delivery purposes. Bioorthogonal chemistry allows for a pretargeting approach. Higher target-to-background drug accumulation ratios can be achieved. Pretargeting can also be used to induce internalization processes or trigger controlled drug release. Colloidal gold nanoparticles (AuNPs) have attracted widespread interest as drug delivery vectors within the last decades. Here, we demonstrate for the first time the possibility to successfully ligate AuNPs in vivo to pretargeted monoclonal antibodies. We believe that this possibility will facilitate the development of AuNPs for clinical use and ultimately, improve state-of-the-art patient care.

AB - Combining nanotechnology and bioorthogonal chemistry for theranostic strategies offers the possibility to develop next generation nanomedicines. These materials are thought to increase therapeutic outcome and improve current cancer management. Due to their size, nanomedicines target tumors passively. Thus, they can be used for drug delivery purposes. Bioorthogonal chemistry allows for a pretargeting approach. Higher target-to-background drug accumulation ratios can be achieved. Pretargeting can also be used to induce internalization processes or trigger controlled drug release. Colloidal gold nanoparticles (AuNPs) have attracted widespread interest as drug delivery vectors within the last decades. Here, we demonstrate for the first time the possibility to successfully ligate AuNPs in vivo to pretargeted monoclonal antibodies. We believe that this possibility will facilitate the development of AuNPs for clinical use and ultimately, improve state-of-the-art patient care.

KW - bioorthogonal chemistry

KW - click chemistry

KW - gold nanoparticles

KW - pretargeting

KW - tetrazine ligation

U2 - 10.1002/chem.202201847

DO - 10.1002/chem.202201847

M3 - Journal article

C2 - 35851967

AN - SCOPUS:85137220252

VL - 28

JO - Chemistry: A European Journal

JF - Chemistry: A European Journal

SN - 0947-6539

IS - 61

M1 - e202201847

ER -

ID: 319793130