BK channel activators and their therapeutic perspectives

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

BK channel activators and their therapeutic perspectives. / Bentzen, Bo Hjorth; Olesen, Søren-Peter; Rønn, Lars C B; Grunnet, Morten.

In: Frontiers in Physiology, Vol. 5, 2014, p. 1-12.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bentzen, BH, Olesen, S-P, Rønn, LCB & Grunnet, M 2014, 'BK channel activators and their therapeutic perspectives', Frontiers in Physiology, vol. 5, pp. 1-12. https://doi.org/10.3389/fphys.2014.00389

APA

Bentzen, B. H., Olesen, S-P., Rønn, L. C. B., & Grunnet, M. (2014). BK channel activators and their therapeutic perspectives. Frontiers in Physiology, 5, 1-12. https://doi.org/10.3389/fphys.2014.00389

Vancouver

Bentzen BH, Olesen S-P, Rønn LCB, Grunnet M. BK channel activators and their therapeutic perspectives. Frontiers in Physiology. 2014;5:1-12. https://doi.org/10.3389/fphys.2014.00389

Author

Bentzen, Bo Hjorth ; Olesen, Søren-Peter ; Rønn, Lars C B ; Grunnet, Morten. / BK channel activators and their therapeutic perspectives. In: Frontiers in Physiology. 2014 ; Vol. 5. pp. 1-12.

Bibtex

@article{962cdfa8f0ca4264af29715bc6ce4d5a,
title = "BK channel activators and their therapeutic perspectives",
abstract = "The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increases in intracellular calcium to outward hyperpolarizing potassium currents. Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Additionally, cardioprotective roles have been revealed in recent years. After a short introduction to the structure, function and regulation of BK channels, we review the small organic molecules activating BK channels and how these tool compounds have helped delineate the roles of BK channels in health and disease.",
author = "Bentzen, {Bo Hjorth} and S{\o}ren-Peter Olesen and R{\o}nn, {Lars C B} and Morten Grunnet",
year = "2014",
doi = "10.3389/fphys.2014.00389",
language = "English",
volume = "5",
pages = "1--12",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - BK channel activators and their therapeutic perspectives

AU - Bentzen, Bo Hjorth

AU - Olesen, Søren-Peter

AU - Rønn, Lars C B

AU - Grunnet, Morten

PY - 2014

Y1 - 2014

N2 - The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increases in intracellular calcium to outward hyperpolarizing potassium currents. Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Additionally, cardioprotective roles have been revealed in recent years. After a short introduction to the structure, function and regulation of BK channels, we review the small organic molecules activating BK channels and how these tool compounds have helped delineate the roles of BK channels in health and disease.

AB - The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increases in intracellular calcium to outward hyperpolarizing potassium currents. Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Additionally, cardioprotective roles have been revealed in recent years. After a short introduction to the structure, function and regulation of BK channels, we review the small organic molecules activating BK channels and how these tool compounds have helped delineate the roles of BK channels in health and disease.

U2 - 10.3389/fphys.2014.00389

DO - 10.3389/fphys.2014.00389

M3 - Journal article

C2 - 25346695

VL - 5

SP - 1

EP - 12

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

ER -

ID: 135363229