Cancer-induced Bone Pain Impairs Burrowing Behaviour in Mouse and Rat

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Cancer-induced Bone Pain Impairs Burrowing Behaviour in Mouse and Rat. / Sliepen, Sonny Hermanus Johannes; Diaz-Delcastillo, Marta; Korioth, Johanna; Olsen, Rikke Brix; Appel, Camilla Kristine; Christoph, Thomas; Heegaard, Anne-Marie; Rutten, Kris.

In: In Vivo, Vol. 33, No. 4, 2019, p. 1125-1132.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sliepen, SHJ, Diaz-Delcastillo, M, Korioth, J, Olsen, RB, Appel, CK, Christoph, T, Heegaard, A-M & Rutten, K 2019, 'Cancer-induced Bone Pain Impairs Burrowing Behaviour in Mouse and Rat', In Vivo, vol. 33, no. 4, pp. 1125-1132. https://doi.org/10.21873/invivo.11582

APA

Sliepen, S. H. J., Diaz-Delcastillo, M., Korioth, J., Olsen, R. B., Appel, C. K., Christoph, T., Heegaard, A-M., & Rutten, K. (2019). Cancer-induced Bone Pain Impairs Burrowing Behaviour in Mouse and Rat. In Vivo, 33(4), 1125-1132. https://doi.org/10.21873/invivo.11582

Vancouver

Sliepen SHJ, Diaz-Delcastillo M, Korioth J, Olsen RB, Appel CK, Christoph T et al. Cancer-induced Bone Pain Impairs Burrowing Behaviour in Mouse and Rat. In Vivo. 2019;33(4):1125-1132. https://doi.org/10.21873/invivo.11582

Author

Sliepen, Sonny Hermanus Johannes ; Diaz-Delcastillo, Marta ; Korioth, Johanna ; Olsen, Rikke Brix ; Appel, Camilla Kristine ; Christoph, Thomas ; Heegaard, Anne-Marie ; Rutten, Kris. / Cancer-induced Bone Pain Impairs Burrowing Behaviour in Mouse and Rat. In: In Vivo. 2019 ; Vol. 33, No. 4. pp. 1125-1132.

Bibtex

@article{bcba536602e147f4a02373c154bebd69,
title = "Cancer-induced Bone Pain Impairs Burrowing Behaviour in Mouse and Rat",
abstract = "BACKGROUND: Cancer-induced bone pain remains a serious public health concern, with a need for translational behavioural tests in order to assess nociception in preclinical models of this condition. Burrowing is an innate, ethologically relevant rodent behaviour that has been proven sensitive to chronic pain conditions. Herein, we studied for the first time whether burrowing performance is altered in preclinical models of cancer-induced bone pain.MATERIALS AND METHODS: Mice and rats were inoculated with syngeneic breast cancer cells. Bone degradation was radiographically evaluated and nociception was assessed in limb-use and burrowing tests.RESULTS: Cancer-bearing rodents showed reduced relative bone density and limb-use scores, confirming disease development. Burrowing performance decreased over time in both rodent models.CONCLUSION: Burrowing performance was reduced in both rodent models, indicating that the burrowing test is a relevant and reproducible behavioural test for assessing disease development in both mouse and rat models of cancer-induced bone pain.",
keywords = "Animals, Behavior, Animal, Bone Neoplasms/complications, Cancer Pain/diagnosis, Case-Control Studies, Disease Models, Animal, Male, Mice, Pain Measurement/methods, Rats",
author = "Sliepen, {Sonny Hermanus Johannes} and Marta Diaz-Delcastillo and Johanna Korioth and Olsen, {Rikke Brix} and Appel, {Camilla Kristine} and Thomas Christoph and Anne-Marie Heegaard and Kris Rutten",
note = "Copyright{\textcopyright} 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.",
year = "2019",
doi = "10.21873/invivo.11582",
language = "English",
volume = "33",
pages = "1125--1132",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "4",

}

RIS

TY - JOUR

T1 - Cancer-induced Bone Pain Impairs Burrowing Behaviour in Mouse and Rat

AU - Sliepen, Sonny Hermanus Johannes

AU - Diaz-Delcastillo, Marta

AU - Korioth, Johanna

AU - Olsen, Rikke Brix

AU - Appel, Camilla Kristine

AU - Christoph, Thomas

AU - Heegaard, Anne-Marie

AU - Rutten, Kris

N1 - Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Cancer-induced bone pain remains a serious public health concern, with a need for translational behavioural tests in order to assess nociception in preclinical models of this condition. Burrowing is an innate, ethologically relevant rodent behaviour that has been proven sensitive to chronic pain conditions. Herein, we studied for the first time whether burrowing performance is altered in preclinical models of cancer-induced bone pain.MATERIALS AND METHODS: Mice and rats were inoculated with syngeneic breast cancer cells. Bone degradation was radiographically evaluated and nociception was assessed in limb-use and burrowing tests.RESULTS: Cancer-bearing rodents showed reduced relative bone density and limb-use scores, confirming disease development. Burrowing performance decreased over time in both rodent models.CONCLUSION: Burrowing performance was reduced in both rodent models, indicating that the burrowing test is a relevant and reproducible behavioural test for assessing disease development in both mouse and rat models of cancer-induced bone pain.

AB - BACKGROUND: Cancer-induced bone pain remains a serious public health concern, with a need for translational behavioural tests in order to assess nociception in preclinical models of this condition. Burrowing is an innate, ethologically relevant rodent behaviour that has been proven sensitive to chronic pain conditions. Herein, we studied for the first time whether burrowing performance is altered in preclinical models of cancer-induced bone pain.MATERIALS AND METHODS: Mice and rats were inoculated with syngeneic breast cancer cells. Bone degradation was radiographically evaluated and nociception was assessed in limb-use and burrowing tests.RESULTS: Cancer-bearing rodents showed reduced relative bone density and limb-use scores, confirming disease development. Burrowing performance decreased over time in both rodent models.CONCLUSION: Burrowing performance was reduced in both rodent models, indicating that the burrowing test is a relevant and reproducible behavioural test for assessing disease development in both mouse and rat models of cancer-induced bone pain.

KW - Animals

KW - Behavior, Animal

KW - Bone Neoplasms/complications

KW - Cancer Pain/diagnosis

KW - Case-Control Studies

KW - Disease Models, Animal

KW - Male

KW - Mice

KW - Pain Measurement/methods

KW - Rats

U2 - 10.21873/invivo.11582

DO - 10.21873/invivo.11582

M3 - Journal article

C2 - 31280201

VL - 33

SP - 1125

EP - 1132

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 4

ER -

ID: 240983747