Characterization of phenytoin, carbamazepine, vinpocetine and clorgyline simultaneous effects on sodium channels and catecholamine metabolism in rat striatal nerve endings

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Characterization of phenytoin, carbamazepine, vinpocetine and clorgyline simultaneous effects on sodium channels and catecholamine metabolism in rat striatal nerve endings. / Sitges, María; Aldana, Blanca I.; Chiu, Luz M.; Nekrassov, Vladimir.

In: Neurochemical Research, Vol. 34, No. 3, 03.2009, p. 470-479.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sitges, M, Aldana, BI, Chiu, LM & Nekrassov, V 2009, 'Characterization of phenytoin, carbamazepine, vinpocetine and clorgyline simultaneous effects on sodium channels and catecholamine metabolism in rat striatal nerve endings', Neurochemical Research, vol. 34, no. 3, pp. 470-479. https://doi.org/10.1007/s11064-008-9805-7

APA

Sitges, M., Aldana, B. I., Chiu, L. M., & Nekrassov, V. (2009). Characterization of phenytoin, carbamazepine, vinpocetine and clorgyline simultaneous effects on sodium channels and catecholamine metabolism in rat striatal nerve endings. Neurochemical Research, 34(3), 470-479. https://doi.org/10.1007/s11064-008-9805-7

Vancouver

Sitges M, Aldana BI, Chiu LM, Nekrassov V. Characterization of phenytoin, carbamazepine, vinpocetine and clorgyline simultaneous effects on sodium channels and catecholamine metabolism in rat striatal nerve endings. Neurochemical Research. 2009 Mar;34(3):470-479. https://doi.org/10.1007/s11064-008-9805-7

Author

Sitges, María ; Aldana, Blanca I. ; Chiu, Luz M. ; Nekrassov, Vladimir. / Characterization of phenytoin, carbamazepine, vinpocetine and clorgyline simultaneous effects on sodium channels and catecholamine metabolism in rat striatal nerve endings. In: Neurochemical Research. 2009 ; Vol. 34, No. 3. pp. 470-479.

Bibtex

@article{723440e1cbe947ed8909379aa7d01c53,
title = "Characterization of phenytoin, carbamazepine, vinpocetine and clorgyline simultaneous effects on sodium channels and catecholamine metabolism in rat striatal nerve endings",
abstract = "The effects of two classic antiepileptic drugs (carbamazepine and phenytoin), a potential antiepileptic (vinpocetine) and a monoamine-oxidase inhibitor (clorgyline) on the simultaneous changes (detected by HPLC) on Glu, Asp, dopamine and DOPAC inside and outside striatal isolated nerve endings were investigated. Under resting conditions phenytoin, carbamazepine and clorgyline increased dopamine release. Phenytoin and clorgyline increased internal dopamine and decreased DOPAC formation. Carbamazepine decreased internal dopamine and practically did not change DOPAC formation. Glu and Asp release was unchanged. Neurotransmitter release induced by the Na+ channel opener veratridine was reduced by all the antiepileptic drugs tested, except phenytoin which, like clorgyline, facilitated veratridine-induced dopamine release. We conclude that besides the antagonism exerted by carbamazepine, phenytoin and vinpocetine on excitatory neurotransmitters release triggered by Na+ channel activation, that might importantly contribute to their anticonvulsant action, they exert different actions on striatal dopamine distribution, that might explain their different side effect profiles.",
keywords = "Antiepileptic drugs, Aspartate, DOPAC, Dopamine, Glutamate, Monoamino-oxidase, Veratridine",
author = "Mar{\'i}a Sitges and Aldana, {Blanca I.} and Chiu, {Luz M.} and Vladimir Nekrassov",
note = "Funding Information: Acknowledgments The authors thank Araceli Guarneros for her excellent technical assistance. This work was partially supported by grants 225008 from PAPIIT and D-48695 from SEP-CONACYT. Blanca I. Aldana Garc{\'i}a scholarship was also supported by grant 225008 from PAPIIT.",
year = "2009",
month = mar,
doi = "10.1007/s11064-008-9805-7",
language = "English",
volume = "34",
pages = "470--479",
journal = "Neurochemical Research",
issn = "0364-3190",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Characterization of phenytoin, carbamazepine, vinpocetine and clorgyline simultaneous effects on sodium channels and catecholamine metabolism in rat striatal nerve endings

AU - Sitges, María

AU - Aldana, Blanca I.

AU - Chiu, Luz M.

AU - Nekrassov, Vladimir

N1 - Funding Information: Acknowledgments The authors thank Araceli Guarneros for her excellent technical assistance. This work was partially supported by grants 225008 from PAPIIT and D-48695 from SEP-CONACYT. Blanca I. Aldana García scholarship was also supported by grant 225008 from PAPIIT.

PY - 2009/3

Y1 - 2009/3

N2 - The effects of two classic antiepileptic drugs (carbamazepine and phenytoin), a potential antiepileptic (vinpocetine) and a monoamine-oxidase inhibitor (clorgyline) on the simultaneous changes (detected by HPLC) on Glu, Asp, dopamine and DOPAC inside and outside striatal isolated nerve endings were investigated. Under resting conditions phenytoin, carbamazepine and clorgyline increased dopamine release. Phenytoin and clorgyline increased internal dopamine and decreased DOPAC formation. Carbamazepine decreased internal dopamine and practically did not change DOPAC formation. Glu and Asp release was unchanged. Neurotransmitter release induced by the Na+ channel opener veratridine was reduced by all the antiepileptic drugs tested, except phenytoin which, like clorgyline, facilitated veratridine-induced dopamine release. We conclude that besides the antagonism exerted by carbamazepine, phenytoin and vinpocetine on excitatory neurotransmitters release triggered by Na+ channel activation, that might importantly contribute to their anticonvulsant action, they exert different actions on striatal dopamine distribution, that might explain their different side effect profiles.

AB - The effects of two classic antiepileptic drugs (carbamazepine and phenytoin), a potential antiepileptic (vinpocetine) and a monoamine-oxidase inhibitor (clorgyline) on the simultaneous changes (detected by HPLC) on Glu, Asp, dopamine and DOPAC inside and outside striatal isolated nerve endings were investigated. Under resting conditions phenytoin, carbamazepine and clorgyline increased dopamine release. Phenytoin and clorgyline increased internal dopamine and decreased DOPAC formation. Carbamazepine decreased internal dopamine and practically did not change DOPAC formation. Glu and Asp release was unchanged. Neurotransmitter release induced by the Na+ channel opener veratridine was reduced by all the antiepileptic drugs tested, except phenytoin which, like clorgyline, facilitated veratridine-induced dopamine release. We conclude that besides the antagonism exerted by carbamazepine, phenytoin and vinpocetine on excitatory neurotransmitters release triggered by Na+ channel activation, that might importantly contribute to their anticonvulsant action, they exert different actions on striatal dopamine distribution, that might explain their different side effect profiles.

KW - Antiepileptic drugs

KW - Aspartate

KW - DOPAC

KW - Dopamine

KW - Glutamate

KW - Monoamino-oxidase

KW - Veratridine

UR - http://www.scopus.com/inward/record.url?scp=59849118877&partnerID=8YFLogxK

U2 - 10.1007/s11064-008-9805-7

DO - 10.1007/s11064-008-9805-7

M3 - Journal article

C2 - 18712476

AN - SCOPUS:59849118877

VL - 34

SP - 470

EP - 479

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

IS - 3

ER -

ID: 346539144