Chemogenomics of allosteric binding sites in GPCRs

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Standard

Chemogenomics of allosteric binding sites in GPCRs. / Gloriam, David E.

In: Drug Discovery Today: Technologies, Vol. 10, No. 2, 2013, p. e307-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gloriam, DE 2013, 'Chemogenomics of allosteric binding sites in GPCRs', Drug Discovery Today: Technologies, vol. 10, no. 2, pp. e307-13. https://doi.org/10.1016/j.ddtec.2012.07.010

APA

Gloriam, D. E. (2013). Chemogenomics of allosteric binding sites in GPCRs. Drug Discovery Today: Technologies, 10(2), e307-13. https://doi.org/10.1016/j.ddtec.2012.07.010

Vancouver

Gloriam DE. Chemogenomics of allosteric binding sites in GPCRs. Drug Discovery Today: Technologies. 2013;10(2):e307-13. https://doi.org/10.1016/j.ddtec.2012.07.010

Author

Gloriam, David E. / Chemogenomics of allosteric binding sites in GPCRs. In: Drug Discovery Today: Technologies. 2013 ; Vol. 10, No. 2. pp. e307-13.

Bibtex

@article{9598cae8a09a485ca26c4a5fddb29e10,
title = "Chemogenomics of allosteric binding sites in GPCRs",
abstract = "Chemogenomic techniques connect the chemical and biological domains to establish ligand and target relationships not evident from the individual disciplines. Chemogenomics has been applied in lead generation, target classification, focused library design as well as selectivity and polypharmacology profiling. This review describes recent developments structured into ligand-, target- and combined chemogenomic techniques and applications to allosteric GPCR ligands. It also outlines relative strengths and limitations of these techniques and the impact of the increasing crystallographic data.",
author = "Gloriam, {David E.}",
year = "2013",
doi = "10.1016/j.ddtec.2012.07.010",
language = "English",
volume = "10",
pages = "e307--13",
journal = "Drug Discovery Today: Technologies",
issn = "1740-6749",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Chemogenomics of allosteric binding sites in GPCRs

AU - Gloriam, David E.

PY - 2013

Y1 - 2013

N2 - Chemogenomic techniques connect the chemical and biological domains to establish ligand and target relationships not evident from the individual disciplines. Chemogenomics has been applied in lead generation, target classification, focused library design as well as selectivity and polypharmacology profiling. This review describes recent developments structured into ligand-, target- and combined chemogenomic techniques and applications to allosteric GPCR ligands. It also outlines relative strengths and limitations of these techniques and the impact of the increasing crystallographic data.

AB - Chemogenomic techniques connect the chemical and biological domains to establish ligand and target relationships not evident from the individual disciplines. Chemogenomics has been applied in lead generation, target classification, focused library design as well as selectivity and polypharmacology profiling. This review describes recent developments structured into ligand-, target- and combined chemogenomic techniques and applications to allosteric GPCR ligands. It also outlines relative strengths and limitations of these techniques and the impact of the increasing crystallographic data.

U2 - 10.1016/j.ddtec.2012.07.010

DO - 10.1016/j.ddtec.2012.07.010

M3 - Journal article

C2 - 24050282

VL - 10

SP - e307-13

JO - Drug Discovery Today: Technologies

JF - Drug Discovery Today: Technologies

SN - 1740-6749

IS - 2

ER -

ID: 94028199