Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139. / Ísberg, Vignir; Andersen, Kirsten Bayer; Bisig, Christoph; Dietz, Gunnar Ph; Bräuner-Osborne, Hans; Gloriam, David Erik.

In: Journal of Chemical Information and Modeling, Vol. 54, No. 6, 14.05.2014, p. 1553-1557.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ísberg, V, Andersen, KB, Bisig, C, Dietz, GP, Bräuner-Osborne, H & Gloriam, DE 2014, 'Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139', Journal of Chemical Information and Modeling, vol. 54, no. 6, pp. 1553-1557. https://doi.org/10.1021/ci500197a

APA

Ísberg, V., Andersen, K. B., Bisig, C., Dietz, G. P., Bräuner-Osborne, H., & Gloriam, D. E. (2014). Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139. Journal of Chemical Information and Modeling, 54(6), 1553-1557. https://doi.org/10.1021/ci500197a

Vancouver

Ísberg V, Andersen KB, Bisig C, Dietz GP, Bräuner-Osborne H, Gloriam DE. Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139. Journal of Chemical Information and Modeling. 2014 May 14;54(6):1553-1557. https://doi.org/10.1021/ci500197a

Author

Ísberg, Vignir ; Andersen, Kirsten Bayer ; Bisig, Christoph ; Dietz, Gunnar Ph ; Bräuner-Osborne, Hans ; Gloriam, David Erik. / Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139. In: Journal of Chemical Information and Modeling. 2014 ; Vol. 54, No. 6. pp. 1553-1557.

Bibtex

@article{a8f282a5908b46f8a117bd115ffe38d4,
title = "Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139",
abstract = "GPR139 is an orphan G protein-coupled receptor expressed mainly in the central nervous system. We developed a pharmacophore model based on known GPR139 surrogate agonists which led us to propose aromatic-containing dipeptides as potential ligands. Upon testing, the dipeptides demonstrated agonism in the Gq pathway. Next, testing all 20 proteinogenic L-α-amino acids; L-tryptophan and L-phenylalanine were found to have EC50 values of 220 µM and 320 µM, respectively, making them the first putative endogenous agonists for GPR139.",
author = "Vignir {\'I}sberg and Andersen, {Kirsten Bayer} and Christoph Bisig and Dietz, {Gunnar Ph} and Hans Br{\"a}uner-Osborne and Gloriam, {David Erik}",
year = "2014",
month = may,
day = "14",
doi = "10.1021/ci500197a",
language = "English",
volume = "54",
pages = "1553--1557",
journal = "Journal of Chemical Information and Modeling",
issn = "1549-9596",
publisher = "American Chemical Society",
number = "6",

}

RIS

TY - JOUR

T1 - Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139

AU - Ísberg, Vignir

AU - Andersen, Kirsten Bayer

AU - Bisig, Christoph

AU - Dietz, Gunnar Ph

AU - Bräuner-Osborne, Hans

AU - Gloriam, David Erik

PY - 2014/5/14

Y1 - 2014/5/14

N2 - GPR139 is an orphan G protein-coupled receptor expressed mainly in the central nervous system. We developed a pharmacophore model based on known GPR139 surrogate agonists which led us to propose aromatic-containing dipeptides as potential ligands. Upon testing, the dipeptides demonstrated agonism in the Gq pathway. Next, testing all 20 proteinogenic L-α-amino acids; L-tryptophan and L-phenylalanine were found to have EC50 values of 220 µM and 320 µM, respectively, making them the first putative endogenous agonists for GPR139.

AB - GPR139 is an orphan G protein-coupled receptor expressed mainly in the central nervous system. We developed a pharmacophore model based on known GPR139 surrogate agonists which led us to propose aromatic-containing dipeptides as potential ligands. Upon testing, the dipeptides demonstrated agonism in the Gq pathway. Next, testing all 20 proteinogenic L-α-amino acids; L-tryptophan and L-phenylalanine were found to have EC50 values of 220 µM and 320 µM, respectively, making them the first putative endogenous agonists for GPR139.

U2 - 10.1021/ci500197a

DO - 10.1021/ci500197a

M3 - Journal article

C2 - 24826842

VL - 54

SP - 1553

EP - 1557

JO - Journal of Chemical Information and Modeling

JF - Journal of Chemical Information and Modeling

SN - 1549-9596

IS - 6

ER -

ID: 112862682