Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF
Research output: Contribution to journal › Journal article › Research › peer-review
A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.
| Original language | English |
|---|---|
| Journal | Journal of Organic Chemistry |
| Volume | 78 |
| Issue number | 8 |
| Pages (from-to) | 4190-4195 |
| Number of pages | 6 |
| ISSN | 0022-3263 |
| DOIs | |
| Publication status | Published - 2013 |
ID: 189160330