Controlled generation and use of CO in flow
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Controlled generation and use of CO in flow. / Hansen, Steffen V. F.; Wilson, Zoe E.; Ulven, Trond; Ley, Steven V.
In: Reaction Chemistry & Engineering, Vol. 1, No. 3, 2016, p. 280-287.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Controlled generation and use of CO in flow
AU - Hansen, Steffen V. F.
AU - Wilson, Zoe E.
AU - Ulven, Trond
AU - Ley, Steven V.
PY - 2016
Y1 - 2016
N2 - A method for the generation and use of carbon monoxide in flow chemistry has been developed. By using a tube-in-tube reactor, oxalyl chloride can be conveniently and safely hydrolyzed using a NaOH solution to generate CO in the outer stream, which then passes through AF-2400 semi-permeable inner tubing to enrich a reaction stream where it is consumed. The tube-in-tube reactor allows the generation of CO under conditions which would otherwise be incompatible with the reaction conditions. In this way carbonylations can be successfully performed in flow without the use of pressurized gas cylinders. Both alkoxy- and aminocarbonylation was carried out in flow, including a 320 minute continuous run, as proof of concept.
AB - A method for the generation and use of carbon monoxide in flow chemistry has been developed. By using a tube-in-tube reactor, oxalyl chloride can be conveniently and safely hydrolyzed using a NaOH solution to generate CO in the outer stream, which then passes through AF-2400 semi-permeable inner tubing to enrich a reaction stream where it is consumed. The tube-in-tube reactor allows the generation of CO under conditions which would otherwise be incompatible with the reaction conditions. In this way carbonylations can be successfully performed in flow without the use of pressurized gas cylinders. Both alkoxy- and aminocarbonylation was carried out in flow, including a 320 minute continuous run, as proof of concept.
U2 - 10.1039/C6RE00020G
DO - 10.1039/C6RE00020G
M3 - Journal article
VL - 1
SP - 280
EP - 287
JO - Reaction Chemistry and Engineering
JF - Reaction Chemistry and Engineering
SN - 2058-9883
IS - 3
ER -
ID: 189161682