Convenient access to β-substituted cysteines and β- and γ-mercapto prolines
Research output: Contribution to journal › Journal article › Research › peer-review
Herein we describe a convenient method for the synthesis of the ,8-substituted Cys analogs 1a, b and trans-,8-mercapto proline 1c, from their corresponding a ,,8-unsaturated-a-amino esters using p-methoxybenzyl mercaptan as the sulfur source. The intermediate ,8-thioethers are stable toward chromatographic purification, and after global deprotection the ,8-mercapto amino acids 1a-c are obtained in good to high yields (64%-99%).
| Original language | English |
|---|---|
| Journal | Canadian Journal of Chemistry |
| Volume | 101 |
| Issue number | 5 |
| Pages (from-to) | 326-333 |
| ISSN | 0008-4042 |
| DOIs | |
| Publication status | Published - 2023 |
- cysteine analogs, proline analogs, SITE-SPECIFIC INCORPORATION, UNNATURAL AMINO-ACIDS, PEPTIDOMIMETICS, ANALOGS, DESIGN, TOOL
Research areas
ID: 341260058