Convergent synthesis of 6-substituted phenanthridines via anionic ring closure

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Convergent synthesis of 6-substituted phenanthridines via anionic ring closure. / Lysén, M.; Kristensen, Jesper Langgaard; Vedsø, P.; Begtrup, M.

In: Organic Letters, Vol. 4, No. 2, 01.01.2002, p. 257-259.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lysén, M, Kristensen, JL, Vedsø, P & Begtrup, M 2002, 'Convergent synthesis of 6-substituted phenanthridines via anionic ring closure', Organic Letters, vol. 4, no. 2, pp. 257-259. https://doi.org/10.1021/ol0170051

APA

Lysén, M., Kristensen, J. L., Vedsø, P., & Begtrup, M. (2002). Convergent synthesis of 6-substituted phenanthridines via anionic ring closure. Organic Letters, 4(2), 257-259. https://doi.org/10.1021/ol0170051

Vancouver

Lysén M, Kristensen JL, Vedsø P, Begtrup M. Convergent synthesis of 6-substituted phenanthridines via anionic ring closure. Organic Letters. 2002 Jan 1;4(2):257-259. https://doi.org/10.1021/ol0170051

Author

Lysén, M. ; Kristensen, Jesper Langgaard ; Vedsø, P. ; Begtrup, M. / Convergent synthesis of 6-substituted phenanthridines via anionic ring closure. In: Organic Letters. 2002 ; Vol. 4, No. 2. pp. 257-259.

Bibtex

@article{2e11969ba105466e9fb6085041d0db27,
title = "Convergent synthesis of 6-substituted phenanthridines via anionic ring closure",
abstract = "Chemical equation presented The addition of organometallic derivatives to the cyano group of 2-(2-fluorophenyl)benzonitrile followed by intramolecular nucleophilic substitution produces 6-substituted phenanthridines. Alkyllithiums, aryllithiums, and sterically nondemanding lithium amides reacted at -78 °C to produce the 6-substituted phenanthridines in 82-98% yield upon warming to room temperature. The addition of the corresponding Grignard reagents requires an excess of the organometallic reagent and extented reaction times at elevated temperature.",
author = "M. Lys{\'e}n and Kristensen, {Jesper Langgaard} and P. Veds{\o} and M. Begtrup",
year = "2002",
month = jan,
day = "1",
doi = "10.1021/ol0170051",
language = "English",
volume = "4",
pages = "257--259",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "2",

}

RIS

TY - JOUR

T1 - Convergent synthesis of 6-substituted phenanthridines via anionic ring closure

AU - Lysén, M.

AU - Kristensen, Jesper Langgaard

AU - Vedsø, P.

AU - Begtrup, M.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Chemical equation presented The addition of organometallic derivatives to the cyano group of 2-(2-fluorophenyl)benzonitrile followed by intramolecular nucleophilic substitution produces 6-substituted phenanthridines. Alkyllithiums, aryllithiums, and sterically nondemanding lithium amides reacted at -78 °C to produce the 6-substituted phenanthridines in 82-98% yield upon warming to room temperature. The addition of the corresponding Grignard reagents requires an excess of the organometallic reagent and extented reaction times at elevated temperature.

AB - Chemical equation presented The addition of organometallic derivatives to the cyano group of 2-(2-fluorophenyl)benzonitrile followed by intramolecular nucleophilic substitution produces 6-substituted phenanthridines. Alkyllithiums, aryllithiums, and sterically nondemanding lithium amides reacted at -78 °C to produce the 6-substituted phenanthridines in 82-98% yield upon warming to room temperature. The addition of the corresponding Grignard reagents requires an excess of the organometallic reagent and extented reaction times at elevated temperature.

UR - http://www.scopus.com/inward/record.url?scp=0009303718&partnerID=8YFLogxK

U2 - 10.1021/ol0170051

DO - 10.1021/ol0170051

M3 - Journal article

AN - SCOPUS:0009303718

VL - 4

SP - 257

EP - 259

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 2

ER -

ID: 45438116