Current radiosynthesis strategies for 5-HT2A receptor PET tracers
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Current radiosynthesis strategies for 5-HT2A receptor PET tracers. / Herth, Matthias M; Knudsen, Gitte M.
In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 58, No. 7, 15.06.2015, p. 265-73.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Current radiosynthesis strategies for 5-HT2A receptor PET tracers
AU - Herth, Matthias M
AU - Knudsen, Gitte M
N1 - Copyright © 2015 John Wiley & Sons, Ltd.
PY - 2015/6/15
Y1 - 2015/6/15
N2 - Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5-HT2A R positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT2A R radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes.
AB - Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5-HT2A R positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT2A R radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes.
U2 - 10.1002/jlcr.3288
DO - 10.1002/jlcr.3288
M3 - Journal article
C2 - 25997728
VL - 58
SP - 265
EP - 273
JO - Journal of Labelled Compounds and Radiopharmaceuticals
JF - Journal of Labelled Compounds and Radiopharmaceuticals
SN - 0362-4803
IS - 7
ER -
ID: 151556875