TY - JOUR

T1 - Development of a Divergent Route to Erythrina Alkaloids

AU - Clementson, Sebastian

AU - Jessing, Mikkel

AU - Vital, Paulo J.

AU - Kristensen, Jesper L.

PY - 2020/3/3

Y1 - 2020/3/3

N2 - Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) - one of the most prominent members of this intriguing family of natural products. 1 Introduction 2 Synthetic Strategy 2.1 First Generation 2.2 Second Generation 2.3 Third Generation 2.3.1 Radical Endgame 2.3.2 Completion of the Total Synthesis 3 Conclusion.

AB - Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) - one of the most prominent members of this intriguing family of natural products. 1 Introduction 2 Synthetic Strategy 2.1 First Generation 2.2 Second Generation 2.3 Third Generation 2.3.1 Radical Endgame 2.3.2 Completion of the Total Synthesis 3 Conclusion.

KW - asymmetric allylic alkylation

KW - decarboxylative cross coupling

KW - Erythrina alkaloids

KW - ring closing metathesis

KW - spiroamine

KW - total synthesis

U2 - 10.1055/s-0039-1690792

DO - 10.1055/s-0039-1690792

M3 - Journal article

AN - SCOPUS:85079828311

VL - 31

SP - 327

EP - 333

JO - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis

JF - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis

SN - 0936-5214

IS - 4

M1 - st-2019-a0679-a

ER -