Discovery of a potent and selective GPR120 agonist

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Discovery of a potent and selective GPR120 agonist. / Shimpukade, Bharat; Hudson, Brian D; Hovgaard, Christine Kiel; Milligan, Graeme; Ulven, Trond.

In: Journal of Medicinal Chemistry, Vol. 55, No. 9, 2012, p. 4511-4515.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Shimpukade, B, Hudson, BD, Hovgaard, CK, Milligan, G & Ulven, T 2012, 'Discovery of a potent and selective GPR120 agonist', Journal of Medicinal Chemistry, vol. 55, no. 9, pp. 4511-4515. https://doi.org/10.1021/jm300215x

APA

Shimpukade, B., Hudson, B. D., Hovgaard, C. K., Milligan, G., & Ulven, T. (2012). Discovery of a potent and selective GPR120 agonist. Journal of Medicinal Chemistry, 55(9), 4511-4515. https://doi.org/10.1021/jm300215x

Vancouver

Shimpukade B, Hudson BD, Hovgaard CK, Milligan G, Ulven T. Discovery of a potent and selective GPR120 agonist. Journal of Medicinal Chemistry. 2012;55(9):4511-4515. https://doi.org/10.1021/jm300215x

Author

Shimpukade, Bharat ; Hudson, Brian D ; Hovgaard, Christine Kiel ; Milligan, Graeme ; Ulven, Trond. / Discovery of a potent and selective GPR120 agonist. In: Journal of Medicinal Chemistry. 2012 ; Vol. 55, No. 9. pp. 4511-4515.

Bibtex

@article{34782e2cfcd24efd98fe2a9c7bbbf839,
title = "Discovery of a potent and selective GPR120 agonist",
abstract = "GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases. Further investigation is however hindered by the lack of suitable receptor modulators. Screening of FFA1 ligands provided a lead with moderate activity on GPR120 and moderate selectivity over FFA1. Optimization led to the discovery of the first potent and selective GPR120 agonist.",
author = "Bharat Shimpukade and Hudson, {Brian D} and Hovgaard, {Christine Kiel} and Graeme Milligan and Trond Ulven",
year = "2012",
doi = "10.1021/jm300215x",
language = "English",
volume = "55",
pages = "4511--4515",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "9",

}

RIS

TY - JOUR

T1 - Discovery of a potent and selective GPR120 agonist

AU - Shimpukade, Bharat

AU - Hudson, Brian D

AU - Hovgaard, Christine Kiel

AU - Milligan, Graeme

AU - Ulven, Trond

PY - 2012

Y1 - 2012

N2 - GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases. Further investigation is however hindered by the lack of suitable receptor modulators. Screening of FFA1 ligands provided a lead with moderate activity on GPR120 and moderate selectivity over FFA1. Optimization led to the discovery of the first potent and selective GPR120 agonist.

AB - GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases. Further investigation is however hindered by the lack of suitable receptor modulators. Screening of FFA1 ligands provided a lead with moderate activity on GPR120 and moderate selectivity over FFA1. Optimization led to the discovery of the first potent and selective GPR120 agonist.

U2 - 10.1021/jm300215x

DO - 10.1021/jm300215x

M3 - Journal article

VL - 55

SP - 4511

EP - 4515

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 9

ER -

ID: 189158956