Discovery of oxygentade chalcones as novel antimalarial agents

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Discovery of oxygentade chalcones as novel antimalarial agents. / Kharazmi, A.; Chen, M.; Theander, T.; Christensen, S. B.

In: Annals of Tropical Medicine and Parasitology, Vol. 91, No. SUPPL. 1, 1997, p. S91-S95.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kharazmi, A, Chen, M, Theander, T & Christensen, SB 1997, 'Discovery of oxygentade chalcones as novel antimalarial agents', Annals of Tropical Medicine and Parasitology, vol. 91, no. SUPPL. 1, pp. S91-S95. https://doi.org/10.1080/00034983.1997.11813245

APA

Kharazmi, A., Chen, M., Theander, T., & Christensen, S. B. (1997). Discovery of oxygentade chalcones as novel antimalarial agents. Annals of Tropical Medicine and Parasitology, 91(SUPPL. 1), S91-S95. https://doi.org/10.1080/00034983.1997.11813245

Vancouver

Kharazmi A, Chen M, Theander T, Christensen SB. Discovery of oxygentade chalcones as novel antimalarial agents. Annals of Tropical Medicine and Parasitology. 1997;91(SUPPL. 1):S91-S95. https://doi.org/10.1080/00034983.1997.11813245

Author

Kharazmi, A. ; Chen, M. ; Theander, T. ; Christensen, S. B. / Discovery of oxygentade chalcones as novel antimalarial agents. In: Annals of Tropical Medicine and Parasitology. 1997 ; Vol. 91, No. SUPPL. 1. pp. S91-S95.

Bibtex

@article{685ae48a7dbc4a5dbc064575bf0d1e6f,
title = "Discovery of oxygentade chalcones as novel antimalarial agents",
abstract = "Licochalcone A, a compound isolated from Chinese liquorice roots, inhibited the in-vitro growth of a chloroquine-sensitive (3D7) and a chloroquine-resistant (Dd2) isolate of Plamodium falciparum to a similar extent. When licochalcone A was added to highly synchronised cultures containing mostly rings, trophozoites or schizonts, the growth of all these asexual stages of the parasites was found to be inhibited. When the compound was administered either intraperitoneally or orally for up to 6 days to mice infected with P. yoelii, it protected the rodents from the otherwise lethal infection. In preliminary toxicity studies in rats, oral doses up to 1000 mg licochalcone A/kg body weight did not cause any observable toxicity. Licochalcone A therefore exhibits potent antimalarial activity and shows promise as a potential, new antimalarial drug.",
author = "A. Kharazmi and M. Chen and T. Theander and Christensen, {S. B.}",
year = "1997",
doi = "10.1080/00034983.1997.11813245",
language = "English",
volume = "91",
pages = "S91--S95",
journal = "Pathogens and Global Health",
issn = "2047-7724",
publisher = "Taylor & Francis",
number = "SUPPL. 1",

}

RIS

TY - JOUR

T1 - Discovery of oxygentade chalcones as novel antimalarial agents

AU - Kharazmi, A.

AU - Chen, M.

AU - Theander, T.

AU - Christensen, S. B.

PY - 1997

Y1 - 1997

N2 - Licochalcone A, a compound isolated from Chinese liquorice roots, inhibited the in-vitro growth of a chloroquine-sensitive (3D7) and a chloroquine-resistant (Dd2) isolate of Plamodium falciparum to a similar extent. When licochalcone A was added to highly synchronised cultures containing mostly rings, trophozoites or schizonts, the growth of all these asexual stages of the parasites was found to be inhibited. When the compound was administered either intraperitoneally or orally for up to 6 days to mice infected with P. yoelii, it protected the rodents from the otherwise lethal infection. In preliminary toxicity studies in rats, oral doses up to 1000 mg licochalcone A/kg body weight did not cause any observable toxicity. Licochalcone A therefore exhibits potent antimalarial activity and shows promise as a potential, new antimalarial drug.

AB - Licochalcone A, a compound isolated from Chinese liquorice roots, inhibited the in-vitro growth of a chloroquine-sensitive (3D7) and a chloroquine-resistant (Dd2) isolate of Plamodium falciparum to a similar extent. When licochalcone A was added to highly synchronised cultures containing mostly rings, trophozoites or schizonts, the growth of all these asexual stages of the parasites was found to be inhibited. When the compound was administered either intraperitoneally or orally for up to 6 days to mice infected with P. yoelii, it protected the rodents from the otherwise lethal infection. In preliminary toxicity studies in rats, oral doses up to 1000 mg licochalcone A/kg body weight did not cause any observable toxicity. Licochalcone A therefore exhibits potent antimalarial activity and shows promise as a potential, new antimalarial drug.

U2 - 10.1080/00034983.1997.11813245

DO - 10.1080/00034983.1997.11813245

M3 - Journal article

AN - SCOPUS:0030889149

VL - 91

SP - S91-S95

JO - Pathogens and Global Health

JF - Pathogens and Global Health

SN - 2047-7724

IS - SUPPL. 1

ER -

ID: 232597341