Effect of diet on tissue levels of palmitoylethanolamide

Research output: Contribution to journal › Journal article › Research › peer-review

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Effect of diet on tissue levels of palmitoylethanolamide. / Hansen, Harald S.

In: C N S & Neurological Disorders - Drug Targets, Vol. 12, No. 1, 01.02.2013, p. 17-25.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, HS 2013, 'Effect of diet on tissue levels of palmitoylethanolamide', C N S & Neurological Disorders - Drug Targets, vol. 12, no. 1, pp. 17-25.

APA

Hansen, H. S. (2013). Effect of diet on tissue levels of palmitoylethanolamide. C N S & Neurological Disorders - Drug Targets, 12(1), 17-25.

Vancouver

Hansen HS. Effect of diet on tissue levels of palmitoylethanolamide. C N S & Neurological Disorders - Drug Targets. 2013 Feb 1;12(1):17-25.

Author

Hansen, Harald S. / Effect of diet on tissue levels of palmitoylethanolamide. In: C N S & Neurological Disorders - Drug Targets. 2013 ; Vol. 12, No. 1. pp. 17-25.

Bibtex

@article{73f014c96a60489dbaab2673b6689bd7,
title = "Effect of diet on tissue levels of palmitoylethanolamide",
abstract = "Palmitoylethanolamide (PEA) as well as the other N-acylethanolamines (NAEs), e.g. anandamide, oleoylethanolamide, stearoylethanolamide and linoleoylethanolamide, appear to exist in every mammalian cell at low levels, e.g. a few hundred pmol/g tissue for PEA. Their formation can be stimulated by cellular injury and inflammation. In the brain PEA and other NAEs may have neuroprotective functions. PEA levels in tissues seem hardly to be influenced by variation in intake of dietary fatty acids, except in the small intestine where dietary fat results in decreased levels of PEA and other NAEs. In rat small intestine, PEA, oleoylethanolamide and linoleoylethanolamide have anorectic properties. Of other dietary components, only ethanol is known to influence tissue levels of PEA. Thus, an acute intoxicating dose of ethanol will decrease PEA levels in various areas in the brain of rats. The mechanism behind this effect is not known.",
keywords = "Animals, Brain, Dietary Fats, Endocannabinoids, Ethanol, Ethanolamines, Fatty Acids, Humans, Palmitic Acids, Tissue Distribution, oleoylethanolamide, palmitoylethanolamide, ischemia, Brain injury, Brain Ischemia",
author = "Hansen, {Harald S.}",
year = "2013",
month = feb,
day = "1",
language = "English",
volume = "12",
pages = "17--25",
journal = "CNS and Neurological Disorders - Drug Targets",
issn = "1871-5273",
publisher = "Bentham Science Publishers",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of diet on tissue levels of palmitoylethanolamide

AU - Hansen, Harald S.

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Palmitoylethanolamide (PEA) as well as the other N-acylethanolamines (NAEs), e.g. anandamide, oleoylethanolamide, stearoylethanolamide and linoleoylethanolamide, appear to exist in every mammalian cell at low levels, e.g. a few hundred pmol/g tissue for PEA. Their formation can be stimulated by cellular injury and inflammation. In the brain PEA and other NAEs may have neuroprotective functions. PEA levels in tissues seem hardly to be influenced by variation in intake of dietary fatty acids, except in the small intestine where dietary fat results in decreased levels of PEA and other NAEs. In rat small intestine, PEA, oleoylethanolamide and linoleoylethanolamide have anorectic properties. Of other dietary components, only ethanol is known to influence tissue levels of PEA. Thus, an acute intoxicating dose of ethanol will decrease PEA levels in various areas in the brain of rats. The mechanism behind this effect is not known.

AB - Palmitoylethanolamide (PEA) as well as the other N-acylethanolamines (NAEs), e.g. anandamide, oleoylethanolamide, stearoylethanolamide and linoleoylethanolamide, appear to exist in every mammalian cell at low levels, e.g. a few hundred pmol/g tissue for PEA. Their formation can be stimulated by cellular injury and inflammation. In the brain PEA and other NAEs may have neuroprotective functions. PEA levels in tissues seem hardly to be influenced by variation in intake of dietary fatty acids, except in the small intestine where dietary fat results in decreased levels of PEA and other NAEs. In rat small intestine, PEA, oleoylethanolamide and linoleoylethanolamide have anorectic properties. Of other dietary components, only ethanol is known to influence tissue levels of PEA. Thus, an acute intoxicating dose of ethanol will decrease PEA levels in various areas in the brain of rats. The mechanism behind this effect is not known.

KW - Animals

KW - Brain

KW - Dietary Fats

KW - Endocannabinoids

KW - Ethanol

KW - Ethanolamines

KW - Fatty Acids

KW - Humans

KW - Palmitic Acids

KW - Tissue Distribution

KW - oleoylethanolamide

KW - palmitoylethanolamide

KW - ischemia

KW - Brain injury

KW - Brain Ischemia

M3 - Journal article

C2 - 23394522

VL - 12

SP - 17

EP - 25

JO - CNS and Neurological Disorders - Drug Targets

JF - CNS and Neurological Disorders - Drug Targets

SN - 1871-5273

IS - 1

ER -

ID: 119652338