Effects of amphetamine and methylphenidate on attentional performance and impulsivity in the mouse 5-Choice Serial Reaction Time Task
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Effects of amphetamine and methylphenidate on attentional performance and impulsivity in the mouse 5-Choice Serial Reaction Time Task. / Caballero Puntiverio, Maitane; Fitzpatrick, Ciarán Martin; Woldbye, David Paul Drucker; Andreasen T., Jesper.
In: Journal of Psychopharmacology, Vol. 31, No. 2, 2017, p. 272-283.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Effects of amphetamine and methylphenidate on attentional performance and impulsivity in the mouse 5-Choice Serial Reaction Time Task
AU - Caballero Puntiverio, Maitane
AU - Fitzpatrick, Ciarán Martin
AU - Woldbye, David Paul Drucker
AU - Andreasen T., Jesper
PY - 2017
Y1 - 2017
N2 - Background: Few studies have investigated the effects of conventional attention deficit-hyperactivity disorder (ADHD) medication in the mouse5-choice serial reaction time task (5-CSRTT), and rat studies have yielded inconsistent results.Objective: We aimed to examine the effects of acute methylphenidate (MPH) and amphetamine (AMPH) treatment in the mouse 5-CSRTT.Methods: Trained male C57Bl/6J mice were tested in a variable stimulus duration schedule. Effects of AMPH (0.25, 0.5, and 1 mg/kg) and MPH (0.5,1.0, and 2.0 mg/kg) on discriminative accuracy, omissions, and premature responses were assessed. Saline treatment data determined high- and lowattentive (LA), and high- and low-impulsive (LI) subgroups according to the upper and lower 30th percentiles, respectively.Results: In the LA subgroup accuracy was improved by 0.5 mg/kg AMPH and 2 mg/kg MPH, while no effect was found in the high-attentive (HA)subgroup. Premature responses were increased by 1 mg/kg AMPH and 0.5 mg/kg MPH for all animals, and by 1 mg/kg AMPH for the LI subgroup.Conclusions: The use of variable stimulus duration, along with the division into high- and LA, and high-and LI subgroups, may improve the sensitivityof the 5-CSRTT when investigating drug effects on attention and impulsivity.
AB - Background: Few studies have investigated the effects of conventional attention deficit-hyperactivity disorder (ADHD) medication in the mouse5-choice serial reaction time task (5-CSRTT), and rat studies have yielded inconsistent results.Objective: We aimed to examine the effects of acute methylphenidate (MPH) and amphetamine (AMPH) treatment in the mouse 5-CSRTT.Methods: Trained male C57Bl/6J mice were tested in a variable stimulus duration schedule. Effects of AMPH (0.25, 0.5, and 1 mg/kg) and MPH (0.5,1.0, and 2.0 mg/kg) on discriminative accuracy, omissions, and premature responses were assessed. Saline treatment data determined high- and lowattentive (LA), and high- and low-impulsive (LI) subgroups according to the upper and lower 30th percentiles, respectively.Results: In the LA subgroup accuracy was improved by 0.5 mg/kg AMPH and 2 mg/kg MPH, while no effect was found in the high-attentive (HA)subgroup. Premature responses were increased by 1 mg/kg AMPH and 0.5 mg/kg MPH for all animals, and by 1 mg/kg AMPH for the LI subgroup.Conclusions: The use of variable stimulus duration, along with the division into high- and LA, and high-and LI subgroups, may improve the sensitivityof the 5-CSRTT when investigating drug effects on attention and impulsivity.
U2 - 10.1177/0269881116684339
DO - 10.1177/0269881116684339
M3 - Journal article
C2 - 28093027
VL - 31
SP - 272
EP - 283
JO - Journal of Psychopharmacology
JF - Journal of Psychopharmacology
SN - 0269-8811
IS - 2
ER -
ID: 171598978