Effects of sertraline, duloxetine, vortioxetine, and idazoxan in the rat affective bias test
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Effects of sertraline, duloxetine, vortioxetine, and idazoxan in the rat affective bias test. / Refsgaard, Louise Konradsen; Haubro, Kia; Pickering, Darryl S; Stuart, Sarah; Robinson, Emma; Andreasen T., Jesper.
In: Psychopharmacology, Vol. 233, No. 21, 14.10.2016, p. 3763-3770.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of sertraline, duloxetine, vortioxetine, and idazoxan in the rat affective bias test
AU - Refsgaard, Louise Konradsen
AU - Haubro, Kia
AU - Pickering, Darryl S
AU - Stuart, Sarah
AU - Robinson, Emma
AU - Andreasen T., Jesper
PY - 2016/10/14
Y1 - 2016/10/14
N2 - RationaleAffective biases seemingly play a crucial role for the onset and development of depression. Acute treatment with monoamine-based antidepressants positively influence emotional processing, and an early correction of biases likely results in repeated positive experiences that ultimately lead to improved mood.ObjectivesUsing two conventional antidepressants, sertraline and duloxetine, we aimed to forward the characterization of a newly developed affective bias test (ABT) for rats. Further, we examined the effect of vortioxetine, a recently approved antidepressant, and the α2 adrenoceptor antagonist idazoxan onaffective biases.
AB - RationaleAffective biases seemingly play a crucial role for the onset and development of depression. Acute treatment with monoamine-based antidepressants positively influence emotional processing, and an early correction of biases likely results in repeated positive experiences that ultimately lead to improved mood.ObjectivesUsing two conventional antidepressants, sertraline and duloxetine, we aimed to forward the characterization of a newly developed affective bias test (ABT) for rats. Further, we examined the effect of vortioxetine, a recently approved antidepressant, and the α2 adrenoceptor antagonist idazoxan onaffective biases.
U2 - 10.1007/s00213-016-4407-6
DO - 10.1007/s00213-016-4407-6
M3 - Journal article
C2 - 27572627
VL - 233
SP - 3763
EP - 3770
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 21
ER -
ID: 164572514