Expression and induction of secretory phospholipase A2 group IB in brain

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Expression and induction of secretory phospholipase A2 group IB in brain. / Kolko, Miriam; Christoffersen, Nanna R; Varoqui, Hélène; Bazan, Nicolas G.

In: Cellular & Molecular Neurobiology, Vol. 25, No. 7, 11.2005, p. 1107-22.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kolko, M, Christoffersen, NR, Varoqui, H & Bazan, NG 2005, 'Expression and induction of secretory phospholipase A2 group IB in brain', Cellular & Molecular Neurobiology, vol. 25, no. 7, pp. 1107-22. https://doi.org/10.1007/s10571-005-8221-7

APA

Kolko, M., Christoffersen, N. R., Varoqui, H., & Bazan, N. G. (2005). Expression and induction of secretory phospholipase A2 group IB in brain. Cellular & Molecular Neurobiology, 25(7), 1107-22. https://doi.org/10.1007/s10571-005-8221-7

Vancouver

Kolko M, Christoffersen NR, Varoqui H, Bazan NG. Expression and induction of secretory phospholipase A2 group IB in brain. Cellular & Molecular Neurobiology. 2005 Nov;25(7):1107-22. https://doi.org/10.1007/s10571-005-8221-7

Author

Kolko, Miriam ; Christoffersen, Nanna R ; Varoqui, Hélène ; Bazan, Nicolas G. / Expression and induction of secretory phospholipase A2 group IB in brain. In: Cellular & Molecular Neurobiology. 2005 ; Vol. 25, No. 7. pp. 1107-22.

Bibtex

@article{232e5551edb746c480f59fe570b86971,
title = "Expression and induction of secretory phospholipase A2 group IB in brain",
abstract = "Secretory phospholipases A2 (sPLA2) form a diverse family of enzymes involved in physiologic and pathologic processes. Common among all sPLA2 is the ability to cleave acyl groups of phospholipids at C2 of the glycerol backbone, thereby releasing fatty acid and a lysophospholipid. Several sPLA2 have been cloned and characterized in various tissues. Furthermore, receptors have been identified. In the nervous system sPLA2 groups IIA, IIE, IIF, V, and XII have been identified, and binding sites for sPLA2 group IB (sPLA2-IB) have been found. Here, we report sPLA2-IB in rat and human brain as well as in neurons in primary culture. The distribution of sPLA2-IB seems to be mainly neuronal, with the highest abundance occurring in the cerebral cortex and hippocampus. We also find that genes encoding sPLA2-IB are induced by kainic acid and by electroshock-induced convulsions. Based on the present results we suggest that sPLA2-IB may be a neuronal intercellular signalling modulator.",
keywords = "Animals, Antibody Specificity, Brain, COS Cells, Cells, Cultured, Cercopithecus aethiops, Electroshock, Enzyme Induction, Group IB Phospholipases A2, Humans, Kainic Acid, Male, Neurons, Phospholipases A, Phospholipases A2, RNA, Messenger, Rats, Rats, Sprague-Dawley, Recombinant Proteins, Seizures",
author = "Miriam Kolko and Christoffersen, {Nanna R} and H{\'e}l{\`e}ne Varoqui and Bazan, {Nicolas G}",
year = "2005",
month = nov,
doi = "10.1007/s10571-005-8221-7",
language = "English",
volume = "25",
pages = "1107--22",
journal = "Cellular and Molecular Neurobiology",
issn = "0272-4340",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Expression and induction of secretory phospholipase A2 group IB in brain

AU - Kolko, Miriam

AU - Christoffersen, Nanna R

AU - Varoqui, Hélène

AU - Bazan, Nicolas G

PY - 2005/11

Y1 - 2005/11

N2 - Secretory phospholipases A2 (sPLA2) form a diverse family of enzymes involved in physiologic and pathologic processes. Common among all sPLA2 is the ability to cleave acyl groups of phospholipids at C2 of the glycerol backbone, thereby releasing fatty acid and a lysophospholipid. Several sPLA2 have been cloned and characterized in various tissues. Furthermore, receptors have been identified. In the nervous system sPLA2 groups IIA, IIE, IIF, V, and XII have been identified, and binding sites for sPLA2 group IB (sPLA2-IB) have been found. Here, we report sPLA2-IB in rat and human brain as well as in neurons in primary culture. The distribution of sPLA2-IB seems to be mainly neuronal, with the highest abundance occurring in the cerebral cortex and hippocampus. We also find that genes encoding sPLA2-IB are induced by kainic acid and by electroshock-induced convulsions. Based on the present results we suggest that sPLA2-IB may be a neuronal intercellular signalling modulator.

AB - Secretory phospholipases A2 (sPLA2) form a diverse family of enzymes involved in physiologic and pathologic processes. Common among all sPLA2 is the ability to cleave acyl groups of phospholipids at C2 of the glycerol backbone, thereby releasing fatty acid and a lysophospholipid. Several sPLA2 have been cloned and characterized in various tissues. Furthermore, receptors have been identified. In the nervous system sPLA2 groups IIA, IIE, IIF, V, and XII have been identified, and binding sites for sPLA2 group IB (sPLA2-IB) have been found. Here, we report sPLA2-IB in rat and human brain as well as in neurons in primary culture. The distribution of sPLA2-IB seems to be mainly neuronal, with the highest abundance occurring in the cerebral cortex and hippocampus. We also find that genes encoding sPLA2-IB are induced by kainic acid and by electroshock-induced convulsions. Based on the present results we suggest that sPLA2-IB may be a neuronal intercellular signalling modulator.

KW - Animals

KW - Antibody Specificity

KW - Brain

KW - COS Cells

KW - Cells, Cultured

KW - Cercopithecus aethiops

KW - Electroshock

KW - Enzyme Induction

KW - Group IB Phospholipases A2

KW - Humans

KW - Kainic Acid

KW - Male

KW - Neurons

KW - Phospholipases A

KW - Phospholipases A2

KW - RNA, Messenger

KW - Rats

KW - Rats, Sprague-Dawley

KW - Recombinant Proteins

KW - Seizures

U2 - 10.1007/s10571-005-8221-7

DO - 10.1007/s10571-005-8221-7

M3 - Journal article

C2 - 16392040

VL - 25

SP - 1107

EP - 1122

JO - Cellular and Molecular Neurobiology

JF - Cellular and Molecular Neurobiology

SN - 0272-4340

IS - 7

ER -

ID: 45130961