Fiskeolietilskud og graviditetsvarighed. En randomiseret kontrolleret undersøgelse. [Fish oil supplementation and duration of pregnancy. A randomized controlled trial}
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Fiskeolietilskud og graviditetsvarighed. En randomiseret kontrolleret undersøgelse. [Fish oil supplementation and duration of pregnancy. A randomized controlled trial}. / Olsen, S.F.; Søorensen, J.D.; Secher, N.J.; Hedegaard, M.; Henriksen, T.B.; Hansen, Harald S.; Grant, A.
In: Ugeskrift for Laeger, Vol. 156, No. 9, 28.02.1994, p. 1302-1307.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Fiskeolietilskud og graviditetsvarighed. En randomiseret kontrolleret undersøgelse.
T2 - [Fish oil supplementation and duration of pregnancy. A randomized controlled trial}
AU - Olsen, S.F.
AU - Søorensen, J.D.
AU - Secher, N.J.
AU - Hedegaard, M.
AU - Henriksen, T.B.
AU - Hansen, Harald S.
AU - Grant, A.
PY - 1994/2/28
Y1 - 1994/2/28
N2 - It was hypothesised from previous observational studies in the Faroes and Denmark that dietary marine n-3 fatty acids would prolong the duration of pregnancy and thereby increase the birth weight, by influencing the production of prostaglandins involved in the process of parturition. Five hundred and thirty-three healthy Danish women were randomly assigned in the 30th week of pregnancy to fish oil (2.7 g n-3 fatty acids (4 1-g capsules Pikasol oil) per day), olive oil (4 1-g capsules per day) or no oil supplementation. The three groups differed in mean gestational age at birth (ANOVA, p = 0.006), with the fish oil group ranking highest and the olive oil group lowest. Babies born to women allocated fish oil had on average 4.0 (95% confidence interval 1.5;6.4) days higher gestational age and 107 (95% confidence interval 1;214) g higher weight at birth than babies born to women allocated olive oil; the difference in gestational age depended on the level of fish intake at enrollment, with a low fish intake enhancing the difference. Fish oil supplementation in the third trimester seems to prolong gestation while allowing continued growth of the foetus; this effect seems to explain the difference between the Faroes and Denmark in pregnancy duration.
AB - It was hypothesised from previous observational studies in the Faroes and Denmark that dietary marine n-3 fatty acids would prolong the duration of pregnancy and thereby increase the birth weight, by influencing the production of prostaglandins involved in the process of parturition. Five hundred and thirty-three healthy Danish women were randomly assigned in the 30th week of pregnancy to fish oil (2.7 g n-3 fatty acids (4 1-g capsules Pikasol oil) per day), olive oil (4 1-g capsules per day) or no oil supplementation. The three groups differed in mean gestational age at birth (ANOVA, p = 0.006), with the fish oil group ranking highest and the olive oil group lowest. Babies born to women allocated fish oil had on average 4.0 (95% confidence interval 1.5;6.4) days higher gestational age and 107 (95% confidence interval 1;214) g higher weight at birth than babies born to women allocated olive oil; the difference in gestational age depended on the level of fish intake at enrollment, with a low fish intake enhancing the difference. Fish oil supplementation in the third trimester seems to prolong gestation while allowing continued growth of the foetus; this effect seems to explain the difference between the Faroes and Denmark in pregnancy duration.
UR - http://www.scopus.com/inward/record.url?scp=0028781507&partnerID=8YFLogxK
M3 - Journal article
AN - SCOPUS:0028781507
VL - 156
SP - 1302
EP - 1307
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 9
ER -
ID: 45561922