Fluorine-18 radiolabeling strategies-advantages and disadvantages of currently applied labeling methods

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Fluorine-18 radiolabeling strategies-advantages and disadvantages of currently applied labeling methods. / Edem, Patricia E.; Steen, E. Johanna L.; Kjær, Andreas; Herth, Matthias M.

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates. Elsevier, 2019. p. 29-103.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Edem, PE, Steen, EJL, Kjær, A & Herth, MM 2019, Fluorine-18 radiolabeling strategies-advantages and disadvantages of currently applied labeling methods. in Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates. Elsevier, pp. 29-103. https://doi.org/10.1016/B978-0-12-812958-6.00002-1

APA

Edem, P. E., Steen, E. J. L., Kjær, A., & Herth, M. M. (2019). Fluorine-18 radiolabeling strategies-advantages and disadvantages of currently applied labeling methods. In Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates (pp. 29-103). Elsevier. https://doi.org/10.1016/B978-0-12-812958-6.00002-1

Vancouver

Edem PE, Steen EJL, Kjær A, Herth MM. Fluorine-18 radiolabeling strategies-advantages and disadvantages of currently applied labeling methods. In Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates. Elsevier. 2019. p. 29-103 https://doi.org/10.1016/B978-0-12-812958-6.00002-1

Author

Edem, Patricia E. ; Steen, E. Johanna L. ; Kjær, Andreas ; Herth, Matthias M. / Fluorine-18 radiolabeling strategies-advantages and disadvantages of currently applied labeling methods. Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates. Elsevier, 2019. pp. 29-103

Bibtex

@inbook{eba914545d0d4b37bd8b803b597feed4,
title = "Fluorine-18 radiolabeling strategies-advantages and disadvantages of currently applied labeling methods",
abstract = "The use of fluorine-18 (18F) has had an important impact in medicine since its discovery. Fluorine-18 is the most commonly used isotope in positron emission tomography (PET), which is a noninvasive and sensitive radionuclide-based molecular imaging technology. PET can be used for diagnosis, staging, therapy planning, treatment control, and drug development. Fluorine-18 has ideal nuclear properties for PET, resulting in high resolution, accessibility, and marketability. Furthermore, its nuclear properties result in a low patient radiation burden. From a chemical point of view, fluorine-18 is rather difficult to work with. The fluoride-18 anion possesses limited nucleophilicity. Thus, its chemical applicability is restricted. On the other hand, fluorine-18 gas leads to products with low molar activity (Am), and only a few biological applications can be imaged with low Am. This chapter will provide a broad overview of fluorine-18 chemistry, an in-depth description of challenges, and possible solutions for producing 18F-bioactive molecules and highlight the clinical applicability of the described synthetic strategies. Finally, the chapter will conclude with a critical analysis of the field and provide some considerations moving forward.",
keywords = "18F-labeled radiopharmaceuticals, Fluorine-18, Low molar activity, Positron emission tomography (PET), Prostate specific membrane antigen, Radiofluorination",
author = "Edem, {Patricia E.} and Steen, {E. Johanna L.} and Andreas Kj{\ae}r and Herth, {Matthias M.}",
year = "2019",
doi = "10.1016/B978-0-12-812958-6.00002-1",
language = "English",
isbn = "9780128130391",
pages = "29--103",
booktitle = "Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates",
publisher = "Elsevier",
address = "Netherlands",

}

RIS

TY - CHAP

T1 - Fluorine-18 radiolabeling strategies-advantages and disadvantages of currently applied labeling methods

AU - Edem, Patricia E.

AU - Steen, E. Johanna L.

AU - Kjær, Andreas

AU - Herth, Matthias M.

PY - 2019

Y1 - 2019

N2 - The use of fluorine-18 (18F) has had an important impact in medicine since its discovery. Fluorine-18 is the most commonly used isotope in positron emission tomography (PET), which is a noninvasive and sensitive radionuclide-based molecular imaging technology. PET can be used for diagnosis, staging, therapy planning, treatment control, and drug development. Fluorine-18 has ideal nuclear properties for PET, resulting in high resolution, accessibility, and marketability. Furthermore, its nuclear properties result in a low patient radiation burden. From a chemical point of view, fluorine-18 is rather difficult to work with. The fluoride-18 anion possesses limited nucleophilicity. Thus, its chemical applicability is restricted. On the other hand, fluorine-18 gas leads to products with low molar activity (Am), and only a few biological applications can be imaged with low Am. This chapter will provide a broad overview of fluorine-18 chemistry, an in-depth description of challenges, and possible solutions for producing 18F-bioactive molecules and highlight the clinical applicability of the described synthetic strategies. Finally, the chapter will conclude with a critical analysis of the field and provide some considerations moving forward.

AB - The use of fluorine-18 (18F) has had an important impact in medicine since its discovery. Fluorine-18 is the most commonly used isotope in positron emission tomography (PET), which is a noninvasive and sensitive radionuclide-based molecular imaging technology. PET can be used for diagnosis, staging, therapy planning, treatment control, and drug development. Fluorine-18 has ideal nuclear properties for PET, resulting in high resolution, accessibility, and marketability. Furthermore, its nuclear properties result in a low patient radiation burden. From a chemical point of view, fluorine-18 is rather difficult to work with. The fluoride-18 anion possesses limited nucleophilicity. Thus, its chemical applicability is restricted. On the other hand, fluorine-18 gas leads to products with low molar activity (Am), and only a few biological applications can be imaged with low Am. This chapter will provide a broad overview of fluorine-18 chemistry, an in-depth description of challenges, and possible solutions for producing 18F-bioactive molecules and highlight the clinical applicability of the described synthetic strategies. Finally, the chapter will conclude with a critical analysis of the field and provide some considerations moving forward.

KW - 18F-labeled radiopharmaceuticals

KW - Fluorine-18

KW - Low molar activity

KW - Positron emission tomography (PET)

KW - Prostate specific membrane antigen

KW - Radiofluorination

UR - http://www.scopus.com/inward/record.url?scp=85066450801&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-812958-6.00002-1

DO - 10.1016/B978-0-12-812958-6.00002-1

M3 - Book chapter

AN - SCOPUS:85066450801

SN - 9780128130391

SP - 29

EP - 103

BT - Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates

PB - Elsevier

ER -

ID: 242364560