GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer modelsãnd interface interactions

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

GproteinDb in 2024 : new G protein-GPCR couplings, AlphaFold2-multimer modelsãnd interface interactions. / Pándy-Szeker es, Gáspár; Herrera, Luis P.Taracena; Caroli, Jimmy; Kermani, Ali A.; Kulkarni, Yashraj; Keseru, György M.; Gloriam, David E.

In: Nucleic Acids Research, Vol. 52, No. D1, 2024, p. D466-D475.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pándy-Szeker es, G, Herrera, LPT, Caroli, J, Kermani, AA, Kulkarni, Y, Keseru, GM & Gloriam, DE 2024, 'GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer modelsãnd interface interactions', Nucleic Acids Research, vol. 52, no. D1, pp. D466-D475. https://doi.org/10.1093/nar/gkad1089

APA

Pándy-Szeker es, G., Herrera, L. P. T., Caroli, J., Kermani, A. A., Kulkarni, Y., Keseru, G. M., & Gloriam, D. E. (2024). GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer modelsãnd interface interactions. Nucleic Acids Research, 52(D1), D466-D475. https://doi.org/10.1093/nar/gkad1089

Vancouver

Pándy-Szeker es G, Herrera LPT, Caroli J, Kermani AA, Kulkarni Y, Keseru GM et al. GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer modelsãnd interface interactions. Nucleic Acids Research. 2024;52(D1):D466-D475. https://doi.org/10.1093/nar/gkad1089

Author

Pándy-Szeker es, Gáspár ; Herrera, Luis P.Taracena ; Caroli, Jimmy ; Kermani, Ali A. ; Kulkarni, Yashraj ; Keseru, György M. ; Gloriam, David E. / GproteinDb in 2024 : new G protein-GPCR couplings, AlphaFold2-multimer modelsãnd interface interactions. In: Nucleic Acids Research. 2024 ; Vol. 52, No. D1. pp. D466-D475.

Bibtex

@article{49987c0c629e479ba4cc59af62b78bd9,
title = "GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer models{\~a}nd interface interactions",
abstract = "G proteins{\~a}re the major signal proteins of ∼800 receptors for medicines, hormones, neurotransmitters, t{\~a}st{\~a}nts{\~a}nd odorants. GproteinDb offers integrated genomic, str uct ural,{\~a}nd pharmacological data{\~a}nd tools for{\~a}nalysis, visualization{\~a}nd experiment design. Here, we present the first major update of GproteinDb greatly expanding its coupling data{\~a}nd str uct ural templates,{\~a}dding AlphaFold2 str uct ure models of GPCR-G protein comple x es{\~a}nd{\~a}dv{\~a}ncing the interactiv e{\~a}naly sis tools f or their interf{\~a}ces underlying coupling selectivity. We present insights on coupling{\~a}greement{\~a}cross datasets{\~a}nd parameters, including constitutive{\~a}ctivity,{\~a}gonist-induced{\~a}ctivity{\~a}nd kinetics. GproteinDb is{\~a}ccessible{\~a}t https://gproteindb.org . ",
author = "{P{\'a}ndy-Szeker es}, G{\'a}sp{\'a}r and Herrera, {Luis P.Taracena} and Jimmy Caroli and Kermani, {Ali A.} and Yashraj Kulkarni and Keseru, {Gy{\"o}rgy M.} and Gloriam, {David E.}",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2023.",
year = "2024",
doi = "10.1093/nar/gkad1089",
language = "English",
volume = "52",
pages = "D466--D475",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "D1",

}

RIS

TY - JOUR

T1 - GproteinDb in 2024

T2 - new G protein-GPCR couplings, AlphaFold2-multimer modelsãnd interface interactions

AU - Pándy-Szeker es, Gáspár

AU - Herrera, Luis P.Taracena

AU - Caroli, Jimmy

AU - Kermani, Ali A.

AU - Kulkarni, Yashraj

AU - Keseru, György M.

AU - Gloriam, David E.

N1 - Publisher Copyright: © The Author(s) 2023.

PY - 2024

Y1 - 2024

N2 - G proteinsãre the major signal proteins of ∼800 receptors for medicines, hormones, neurotransmitters, tãstãntsãnd odorants. GproteinDb offers integrated genomic, str uct ural,ãnd pharmacological dataãnd tools forãnalysis, visualizationãnd experiment design. Here, we present the first major update of GproteinDb greatly expanding its coupling dataãnd str uct ural templates,ãdding AlphaFold2 str uct ure models of GPCR-G protein comple x esãndãdvãncing the interactiv eãnaly sis tools f or their interfãces underlying coupling selectivity. We present insights on couplingãgreementãcross datasetsãnd parameters, including constitutiveãctivity,ãgonist-inducedãctivityãnd kinetics. GproteinDb isãccessibleãt https://gproteindb.org .

AB - G proteinsãre the major signal proteins of ∼800 receptors for medicines, hormones, neurotransmitters, tãstãntsãnd odorants. GproteinDb offers integrated genomic, str uct ural,ãnd pharmacological dataãnd tools forãnalysis, visualizationãnd experiment design. Here, we present the first major update of GproteinDb greatly expanding its coupling dataãnd str uct ural templates,ãdding AlphaFold2 str uct ure models of GPCR-G protein comple x esãndãdvãncing the interactiv eãnaly sis tools f or their interfãces underlying coupling selectivity. We present insights on couplingãgreementãcross datasetsãnd parameters, including constitutiveãctivity,ãgonist-inducedãctivityãnd kinetics. GproteinDb isãccessibleãt https://gproteindb.org .

U2 - 10.1093/nar/gkad1089

DO - 10.1093/nar/gkad1089

M3 - Journal article

C2 - 38000391

AN - SCOPUS:85181796268

VL - 52

SP - D466-D475

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - D1

ER -

ID: 380202702