Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production
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- 1-s2.0-S2211124720301674-main
Final published version, 3.71 MB, PDF document
Sencio et al. provide insights into the mechanisms that underlie bacterial superinfection post-influenza. The authors demonstrate that influenza infection remotely alters the production of short-chain fatty acids (SCFAs) by the gut microbiota. Supplementation with acetate or pharmacological activation of the SCFA receptor FFAR2 reduces susceptibility to secondary bacterial infection.
| Original language | English |
|---|---|
| Journal | Cell Reports |
| Volume | 30 |
| Issue number | 9 |
| Pages (from-to) | 2934-2947.e6 |
| ISSN | 2211-1247 |
| DOIs | |
| Publication status | Published - 3 Mar 2020 |
- acetate, bacterial superinfection, food restriction, free fatty acid receptor 2, gut microbiota, influenza A virus, macrophages, microbial dysbiosis, short-chain fatty acid
Research areas
ID: 239723525