High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression

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Standard

High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression. / Egerod, Frederikke N S Lihme; Bartels, Annette; Fristrup, Niels; Borre, Michael; Ørntoft, Torben F; Oleksiewicz, Martin B.; Brunner, Nils; Dyrskjøt, Lars.

In: BMC Cancer, Vol. 9, No. 385, 2009.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Egerod, FNSL, Bartels, A, Fristrup, N, Borre, M, Ørntoft, TF, Oleksiewicz, MB, Brunner, N & Dyrskjøt, L 2009, 'High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression', BMC Cancer, vol. 9, no. 385. https://doi.org/10.1186/1471-2407-9-385

APA

Egerod, F. N. S. L., Bartels, A., Fristrup, N., Borre, M., Ørntoft, T. F., Oleksiewicz, M. B., Brunner, N., & Dyrskjøt, L. (2009). High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression. BMC Cancer, 9(385). https://doi.org/10.1186/1471-2407-9-385

Vancouver

Egerod FNSL, Bartels A, Fristrup N, Borre M, Ørntoft TF, Oleksiewicz MB et al. High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression. BMC Cancer. 2009;9(385). https://doi.org/10.1186/1471-2407-9-385

Author

Egerod, Frederikke N S Lihme ; Bartels, Annette ; Fristrup, Niels ; Borre, Michael ; Ørntoft, Torben F ; Oleksiewicz, Martin B. ; Brunner, Nils ; Dyrskjøt, Lars. / High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression. In: BMC Cancer. 2009 ; Vol. 9, No. 385.

Bibtex

@article{3e5a99a01fb911df8ed1000ea68e967b,
title = "High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression",
abstract = "BACKGROUND: Egr-1 (early growth response-1 transcription factor) has been proposed to be involved in invasion and metastasis processes of human bladder cancer, but Egr-1 protein expression levels in human bladder cancer have not been investigated. In the present study we investigated the expression levels of Egr-1 protein in early stages of human bladder cancer and correlated it to later progression. METHODS: Expression of Egr-1 protein in human bladder cancer was examined by immunohistochemistry, on a tissue microarray constructed from tumors from 289 patients with non-muscle invasive urothelial bladder cancer. RESULTS: The frequency of tumor cells with nuclear Egr-1 immunolabelling correlated to bladder cancer stage, grade and to later progression to muscle-invasive bladder cancer (T2-4). Stage T1 tumors exhibited significantly higher frequencies of tumor cells with nuclear Egr-1 immunolabelling than Ta tumors (P = 0.001). Furthermore, Kaplan-Meier survival analysis showed that a high frequency of tumor cells with nuclear Egr-1 immunolabelling was significantly associated with a higher risk of progression to stage T2-4 (log-rank test, P = 0.035). Tumor cells with nuclear Egr-1 immunolabelling were found to localize at the tumor front in some of the tumor biopsies. CONCLUSION: The results from this study support a potential involvement of Egr-1 in the progression from non-muscle invasive bladder cancers to muscle invasive bladder cancer.",
author = "Egerod, {Frederikke N S Lihme} and Annette Bartels and Niels Fristrup and Michael Borre and {\O}rntoft, {Torben F} and Oleksiewicz, {Martin B.} and Nils Brunner and Lars Dyrskj{\o}t",
note = "Keywords: Disease Progression; Early Growth Response Protein 1; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Staging; Urinary Bladder Neoplasms",
year = "2009",
doi = "10.1186/1471-2407-9-385",
language = "English",
volume = "9",
journal = "B M C Cancer",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",
number = "385",

}

RIS

TY - JOUR

T1 - High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression

AU - Egerod, Frederikke N S Lihme

AU - Bartels, Annette

AU - Fristrup, Niels

AU - Borre, Michael

AU - Ørntoft, Torben F

AU - Oleksiewicz, Martin B.

AU - Brunner, Nils

AU - Dyrskjøt, Lars

N1 - Keywords: Disease Progression; Early Growth Response Protein 1; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Staging; Urinary Bladder Neoplasms

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Egr-1 (early growth response-1 transcription factor) has been proposed to be involved in invasion and metastasis processes of human bladder cancer, but Egr-1 protein expression levels in human bladder cancer have not been investigated. In the present study we investigated the expression levels of Egr-1 protein in early stages of human bladder cancer and correlated it to later progression. METHODS: Expression of Egr-1 protein in human bladder cancer was examined by immunohistochemistry, on a tissue microarray constructed from tumors from 289 patients with non-muscle invasive urothelial bladder cancer. RESULTS: The frequency of tumor cells with nuclear Egr-1 immunolabelling correlated to bladder cancer stage, grade and to later progression to muscle-invasive bladder cancer (T2-4). Stage T1 tumors exhibited significantly higher frequencies of tumor cells with nuclear Egr-1 immunolabelling than Ta tumors (P = 0.001). Furthermore, Kaplan-Meier survival analysis showed that a high frequency of tumor cells with nuclear Egr-1 immunolabelling was significantly associated with a higher risk of progression to stage T2-4 (log-rank test, P = 0.035). Tumor cells with nuclear Egr-1 immunolabelling were found to localize at the tumor front in some of the tumor biopsies. CONCLUSION: The results from this study support a potential involvement of Egr-1 in the progression from non-muscle invasive bladder cancers to muscle invasive bladder cancer.

AB - BACKGROUND: Egr-1 (early growth response-1 transcription factor) has been proposed to be involved in invasion and metastasis processes of human bladder cancer, but Egr-1 protein expression levels in human bladder cancer have not been investigated. In the present study we investigated the expression levels of Egr-1 protein in early stages of human bladder cancer and correlated it to later progression. METHODS: Expression of Egr-1 protein in human bladder cancer was examined by immunohistochemistry, on a tissue microarray constructed from tumors from 289 patients with non-muscle invasive urothelial bladder cancer. RESULTS: The frequency of tumor cells with nuclear Egr-1 immunolabelling correlated to bladder cancer stage, grade and to later progression to muscle-invasive bladder cancer (T2-4). Stage T1 tumors exhibited significantly higher frequencies of tumor cells with nuclear Egr-1 immunolabelling than Ta tumors (P = 0.001). Furthermore, Kaplan-Meier survival analysis showed that a high frequency of tumor cells with nuclear Egr-1 immunolabelling was significantly associated with a higher risk of progression to stage T2-4 (log-rank test, P = 0.035). Tumor cells with nuclear Egr-1 immunolabelling were found to localize at the tumor front in some of the tumor biopsies. CONCLUSION: The results from this study support a potential involvement of Egr-1 in the progression from non-muscle invasive bladder cancers to muscle invasive bladder cancer.

U2 - 10.1186/1471-2407-9-385

DO - 10.1186/1471-2407-9-385

M3 - Journal article

C2 - 19878561

VL - 9

JO - B M C Cancer

JF - B M C Cancer

SN - 1471-2407

IS - 385

ER -

ID: 18153450