High species variation within the repertoire of trace amine receptors

Research output: Contribution to journal › Conference article › Research

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High species variation within the repertoire of trace amine receptors. / Gloriam, David E.; Bjarnadóttir, T K; Schiöth, H B; Fredriksson, R.

In: Annals of the New York Academy of Sciences, 04.2005.

Research output: Contribution to journal › Conference article › Research

Harvard

Gloriam, DE, Bjarnadóttir, TK, Schiöth, HB & Fredriksson, R 2005, 'High species variation within the repertoire of trace amine receptors', Annals of the New York Academy of Sciences. https://doi.org/10.1196/annals.1327.052

APA

Gloriam, D. E., Bjarnadóttir, T. K., Schiöth, H. B., & Fredriksson, R. (2005). High species variation within the repertoire of trace amine receptors. Annals of the New York Academy of Sciences. https://doi.org/10.1196/annals.1327.052

Vancouver

Gloriam DE, Bjarnadóttir TK, Schiöth HB, Fredriksson R. High species variation within the repertoire of trace amine receptors. Annals of the New York Academy of Sciences. 2005 Apr. https://doi.org/10.1196/annals.1327.052

Author

Gloriam, David E. ; Bjarnadóttir, T K ; Schiöth, H B ; Fredriksson, R. / High species variation within the repertoire of trace amine receptors. In: Annals of the New York Academy of Sciences. 2005.

Bibtex

@inproceedings{5e94fe174cf04df785e486fc97d45ac0,
title = "High species variation within the repertoire of trace amine receptors",
abstract = "Using a variety of search strategies, we obtained the complete or nearly complete repertoire of trace amine receptors from humans, mice, rats, zebrafish, pufferfish, and a number of invertebrates. We found that the number of functional receptors varies from 5 to 50 in each genome, showing that this family of GPCRs has a very dynamic gene repertoire. We show that the previously cloned and characterized GPCRs from insects and mollusks are more closely related to mammalian serotonin, dopamine, and adrenalin receptors than to mammalian TA receptors. This suggests that the ability to bind TAs has arisen independently in different developmental lineages.",
keywords = "Amino Acid Sequence, Animals, Genetic Variation, Humans, Molecular Sequence Data, Multigene Family, Phylogeny, Receptors, G-Protein-Coupled, Species Specificity",
author = "Gloriam, {David E.} and Bjarnad{\'o}ttir, {T K} and Schi{\"o}th, {H B} and R Fredriksson",
year = "2005",
month = apr,
doi = "10.1196/annals.1327.052",
language = "English",
journal = "Annals of The Lyceum of Natural History of New York",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

RIS

TY - GEN

T1 - High species variation within the repertoire of trace amine receptors

AU - Gloriam, David E.

AU - Bjarnadóttir, T K

AU - Schiöth, H B

AU - Fredriksson, R

PY - 2005/4

Y1 - 2005/4

N2 - Using a variety of search strategies, we obtained the complete or nearly complete repertoire of trace amine receptors from humans, mice, rats, zebrafish, pufferfish, and a number of invertebrates. We found that the number of functional receptors varies from 5 to 50 in each genome, showing that this family of GPCRs has a very dynamic gene repertoire. We show that the previously cloned and characterized GPCRs from insects and mollusks are more closely related to mammalian serotonin, dopamine, and adrenalin receptors than to mammalian TA receptors. This suggests that the ability to bind TAs has arisen independently in different developmental lineages.

AB - Using a variety of search strategies, we obtained the complete or nearly complete repertoire of trace amine receptors from humans, mice, rats, zebrafish, pufferfish, and a number of invertebrates. We found that the number of functional receptors varies from 5 to 50 in each genome, showing that this family of GPCRs has a very dynamic gene repertoire. We show that the previously cloned and characterized GPCRs from insects and mollusks are more closely related to mammalian serotonin, dopamine, and adrenalin receptors than to mammalian TA receptors. This suggests that the ability to bind TAs has arisen independently in different developmental lineages.

KW - Amino Acid Sequence

KW - Animals

KW - Genetic Variation

KW - Humans

KW - Molecular Sequence Data

KW - Multigene Family

KW - Phylogeny

KW - Receptors, G-Protein-Coupled

KW - Species Specificity

U2 - 10.1196/annals.1327.052

DO - 10.1196/annals.1327.052

M3 - Conference article

C2 - 15891052

JO - Annals of The Lyceum of Natural History of New York

JF - Annals of The Lyceum of Natural History of New York

SN - 0077-8923

ER -

ID: 45812133