How do inositol phosphates regulate calcium signaling?
Research output: Contribution to journal › Journal article › Research › peer-review
Activation of a variety of cell surface receptors results in the phospholipase C-catalyzed hydrolysis of the minor plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate, with concomitant formation of inositol 1,4,5-trisphosphate and diacylglycerol. There is strong evidence that inositol 1,4,5-trisphosphate stimulates Ca2+ release from intracellular stores. The Ca2+-releasing actions of inositol 1,4,5-trisphosphate are terminated by its metabolism through two distinct pathways. Inositol 1,4,5-trisphosphate is dephosphorylated by a 5-phosphatase to inositol 1,4-bisphosphate; alternatively, inositol 1,4,5-trisphosphate can also be phosphorylated to inositol 1,3,4,5-tetrakisphosphate by a 3-kinase. Although the mechanism of Ca2+ mobilization is understood, the precise mechanisms involved in Ca2+ entry are not known; the proposal that inositol 1,4,5-trisphosphate secondarily elicits Ca2+ entry by emptying an intracellular Ca2+ pool is considered.
Original language | English |
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Journal | F A S E B Journal |
Volume | 3 |
Issue number | 8 |
Pages (from-to) | 1899-905 |
Number of pages | 7 |
ISSN | 0892-6638 |
Publication status | Published - 1989 |
Externally published | Yes |
- Animals, Calcium, Calcium Channels, Cell Membrane, Humans, Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Inositol Phosphates, Phosphorylation, Receptors, Cell Surface, Receptors, Cytoplasmic and Nuclear, Signal Transduction, Sugar Phosphates, Type C Phospholipases
Research areas
ID: 43350103