Hypocretin/orexin actions on mesopontine cholinergic systems controling behavioral state

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Hypocretin/orexin actions on mesopontine cholinergic systems controling behavioral state. / Leonard, Christopher S.; Tyler, Christopher J.; Burlet, Sophie; Watanabe, Shigeo; Kohlmeier, Kristi A.

Hypocretins: Integrators of Physiological Functions. Springer US, 2005. p. 153-168.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Leonard, CS, Tyler, CJ, Burlet, S, Watanabe, S & Kohlmeier, KA 2005, Hypocretin/orexin actions on mesopontine cholinergic systems controling behavioral state. in Hypocretins: Integrators of Physiological Functions. Springer US, pp. 153-168. https://doi.org/10.1007/0-387-25446-3_10

APA

Leonard, C. S., Tyler, C. J., Burlet, S., Watanabe, S., & Kohlmeier, K. A. (2005). Hypocretin/orexin actions on mesopontine cholinergic systems controling behavioral state. In Hypocretins: Integrators of Physiological Functions (pp. 153-168). Springer US. https://doi.org/10.1007/0-387-25446-3_10

Vancouver

Leonard CS, Tyler CJ, Burlet S, Watanabe S, Kohlmeier KA. Hypocretin/orexin actions on mesopontine cholinergic systems controling behavioral state. In Hypocretins: Integrators of Physiological Functions. Springer US. 2005. p. 153-168 https://doi.org/10.1007/0-387-25446-3_10

Author

Leonard, Christopher S. ; Tyler, Christopher J. ; Burlet, Sophie ; Watanabe, Shigeo ; Kohlmeier, Kristi A. / Hypocretin/orexin actions on mesopontine cholinergic systems controling behavioral state. Hypocretins: Integrators of Physiological Functions. Springer US, 2005. pp. 153-168

Bibtex

@inbook{27a834c7859f4564a3a4a14c2fdf8519,
title = "Hypocretin/orexin actions on mesopontine cholinergic systems controling behavioral state",
abstract = "In the short time since the hypocretin/orexin peptide system was discovered,1,2 a remarkable body of evidence has accumulated indicating this system's important role in regulating feeding, energy metabolism and arousal.3-6 Considerable progress has also been made identifying the CNS targets and actions of the two hypocretin/orexin peptides (Hcrt/Orx-A and -B) [cf 7]. We have been interested in understanding the actions of Hcrt/Orx on brainstem cholinergic and monoaminergic systems since these systems are involved with controlling arousal and sleep. Considering the extensive innervation by Hcrt/Orx afferents8 and the robust expression of orexin receptor message in these structures,9 it is likely that important components of the wake-promoting and REM suppressing abilities of Hcrt/Orx10,11 are mediated through actions on these systems.12-14 Here we discuss some of our recent findings concerning Hcrt/Orx actions on both the cholinergic and non-cholinergic neurons of the laterodorsal tegmental (LDT) nucleus which form part of the ascending cholinergic reticular system.15,16.",
author = "Leonard, {Christopher S.} and Tyler, {Christopher J.} and Sophie Burlet and Shigeo Watanabe and Kohlmeier, {Kristi A.}",
year = "2005",
month = jan,
day = "1",
doi = "10.1007/0-387-25446-3_10",
language = "English",
isbn = "038725000X",
pages = "153--168",
booktitle = "Hypocretins",
publisher = "Springer US",
address = "United States",

}

RIS

TY - CHAP

T1 - Hypocretin/orexin actions on mesopontine cholinergic systems controling behavioral state

AU - Leonard, Christopher S.

AU - Tyler, Christopher J.

AU - Burlet, Sophie

AU - Watanabe, Shigeo

AU - Kohlmeier, Kristi A.

PY - 2005/1/1

Y1 - 2005/1/1

N2 - In the short time since the hypocretin/orexin peptide system was discovered,1,2 a remarkable body of evidence has accumulated indicating this system's important role in regulating feeding, energy metabolism and arousal.3-6 Considerable progress has also been made identifying the CNS targets and actions of the two hypocretin/orexin peptides (Hcrt/Orx-A and -B) [cf 7]. We have been interested in understanding the actions of Hcrt/Orx on brainstem cholinergic and monoaminergic systems since these systems are involved with controlling arousal and sleep. Considering the extensive innervation by Hcrt/Orx afferents8 and the robust expression of orexin receptor message in these structures,9 it is likely that important components of the wake-promoting and REM suppressing abilities of Hcrt/Orx10,11 are mediated through actions on these systems.12-14 Here we discuss some of our recent findings concerning Hcrt/Orx actions on both the cholinergic and non-cholinergic neurons of the laterodorsal tegmental (LDT) nucleus which form part of the ascending cholinergic reticular system.15,16.

AB - In the short time since the hypocretin/orexin peptide system was discovered,1,2 a remarkable body of evidence has accumulated indicating this system's important role in regulating feeding, energy metabolism and arousal.3-6 Considerable progress has also been made identifying the CNS targets and actions of the two hypocretin/orexin peptides (Hcrt/Orx-A and -B) [cf 7]. We have been interested in understanding the actions of Hcrt/Orx on brainstem cholinergic and monoaminergic systems since these systems are involved with controlling arousal and sleep. Considering the extensive innervation by Hcrt/Orx afferents8 and the robust expression of orexin receptor message in these structures,9 it is likely that important components of the wake-promoting and REM suppressing abilities of Hcrt/Orx10,11 are mediated through actions on these systems.12-14 Here we discuss some of our recent findings concerning Hcrt/Orx actions on both the cholinergic and non-cholinergic neurons of the laterodorsal tegmental (LDT) nucleus which form part of the ascending cholinergic reticular system.15,16.

UR - http://www.scopus.com/inward/record.url?scp=84919865451&partnerID=8YFLogxK

U2 - 10.1007/0-387-25446-3_10

DO - 10.1007/0-387-25446-3_10

M3 - Book chapter

AN - SCOPUS:84919865451

SN - 038725000X

SN - 9780387250007

SP - 153

EP - 168

BT - Hypocretins

PB - Springer US

ER -

ID: 203010451