Identifying immunogenic CD4+ T-cell epitopes of Myeloid cell leukemia 1 using overlapping 20-mer peptides spanning the whole protein.

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Standard

Identifying immunogenic CD4+ T-cell epitopes of Myeloid cell leukemia 1 using overlapping 20-mer peptides spanning the whole protein. / Woodworth, Joshua S.; Agger, Else Marie; Hansen, Paul Robert.

Proceedings of the 24th American Peptide Symposium Ved Srivastava, Andrei Yudin, and Michal Lebl (Editors) American Peptide Society. 2015. p. 262-63.

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Harvard

Woodworth, JS, Agger, EM & Hansen, PR 2015, Identifying immunogenic CD4+ T-cell epitopes of Myeloid cell leukemia 1 using overlapping 20-mer peptides spanning the whole protein. in Proceedings of the 24th American Peptide Symposium Ved Srivastava, Andrei Yudin, and Michal Lebl (Editors) American Peptide Society. pp. 262-63. <http://www.5z.com/24APS/24APS_online.pdf>

APA

Woodworth, J. S., Agger, E. M., & Hansen, P. R. (2015). Identifying immunogenic CD4+ T-cell epitopes of Myeloid cell leukemia 1 using overlapping 20-mer peptides spanning the whole protein. In Proceedings of the 24th American Peptide Symposium Ved Srivastava, Andrei Yudin, and Michal Lebl (Editors) American Peptide Society (pp. 262-63) http://www.5z.com/24APS/24APS_online.pdf

Vancouver

Woodworth JS, Agger EM, Hansen PR. Identifying immunogenic CD4+ T-cell epitopes of Myeloid cell leukemia 1 using overlapping 20-mer peptides spanning the whole protein. In Proceedings of the 24th American Peptide Symposium Ved Srivastava, Andrei Yudin, and Michal Lebl (Editors) American Peptide Society. 2015. p. 262-63

Author

Woodworth, Joshua S. ; Agger, Else Marie ; Hansen, Paul Robert. / Identifying immunogenic CD4+ T-cell epitopes of Myeloid cell leukemia 1 using overlapping 20-mer peptides spanning the whole protein. Proceedings of the 24th American Peptide Symposium Ved Srivastava, Andrei Yudin, and Michal Lebl (Editors) American Peptide Society. 2015. pp. 262-63

Bibtex

@inproceedings{0ff9147e360c4e079b29a96e12835d91,
title = "Identifying immunogenic CD4+ T-cell epitopes of Myeloid cell leukemia 1 using overlapping 20-mer peptides spanning the whole protein.",
abstract = "Myeloid cell leukemia 1 (Mcl-1) is an anti-apoptotic protein which is overexpressed in variousleukemia and other cancers [1]. Mcl-1 has a very short half-life [2], which has been suggested as amolecular mechanism for cells to switch into either the survival or apoptotic pathways in response todifferent stresses [3]. Recently, it has been demonstrated that downregulation of Mcl-1 by variouspharmacological agents or genetic approaches dramatically increases ABT-737 lethality in variousmalignant cell types [4]. Different strategies for targeting Mcl-1 include (i) small interfering RNA [5](ii) small-molecule inhibitors [6] and (iii) peptide inhibitors [7]. In recent years, therapeuticvaccination with synthetic peptides derived from anti-apoptotic proteins such as Mcl-1 has emergedas a promising strategy against hematological cancers.In this study, 34 overlapping 20-mer peptides, spanning the entire Mcl-1 protein, were adjuvantedwith cationic liposomes [8] and tested in three different mouse strains with varied MajorHistocompatibility Complex (MHC) haplotypes (FVB [H-2q], CB6F1[H-2b/d], B6CBAF1 [H-2b/k])to identify immunogenic CD4+ T-cell epitopes.",
author = "Woodworth, {Joshua S.} and Agger, {Else Marie} and Hansen, {Paul Robert}",
year = "2015",
language = "English",
pages = "262--63",
booktitle = "Proceedings of the 24th American Peptide Symposium Ved Srivastava, Andrei Yudin, and Michal Lebl (Editors) American Peptide Society",

}

RIS

TY - GEN

T1 - Identifying immunogenic CD4+ T-cell epitopes of Myeloid cell leukemia 1 using overlapping 20-mer peptides spanning the whole protein.

AU - Woodworth, Joshua S.

AU - Agger, Else Marie

AU - Hansen, Paul Robert

PY - 2015

Y1 - 2015

N2 - Myeloid cell leukemia 1 (Mcl-1) is an anti-apoptotic protein which is overexpressed in variousleukemia and other cancers [1]. Mcl-1 has a very short half-life [2], which has been suggested as amolecular mechanism for cells to switch into either the survival or apoptotic pathways in response todifferent stresses [3]. Recently, it has been demonstrated that downregulation of Mcl-1 by variouspharmacological agents or genetic approaches dramatically increases ABT-737 lethality in variousmalignant cell types [4]. Different strategies for targeting Mcl-1 include (i) small interfering RNA [5](ii) small-molecule inhibitors [6] and (iii) peptide inhibitors [7]. In recent years, therapeuticvaccination with synthetic peptides derived from anti-apoptotic proteins such as Mcl-1 has emergedas a promising strategy against hematological cancers.In this study, 34 overlapping 20-mer peptides, spanning the entire Mcl-1 protein, were adjuvantedwith cationic liposomes [8] and tested in three different mouse strains with varied MajorHistocompatibility Complex (MHC) haplotypes (FVB [H-2q], CB6F1[H-2b/d], B6CBAF1 [H-2b/k])to identify immunogenic CD4+ T-cell epitopes.

AB - Myeloid cell leukemia 1 (Mcl-1) is an anti-apoptotic protein which is overexpressed in variousleukemia and other cancers [1]. Mcl-1 has a very short half-life [2], which has been suggested as amolecular mechanism for cells to switch into either the survival or apoptotic pathways in response todifferent stresses [3]. Recently, it has been demonstrated that downregulation of Mcl-1 by variouspharmacological agents or genetic approaches dramatically increases ABT-737 lethality in variousmalignant cell types [4]. Different strategies for targeting Mcl-1 include (i) small interfering RNA [5](ii) small-molecule inhibitors [6] and (iii) peptide inhibitors [7]. In recent years, therapeuticvaccination with synthetic peptides derived from anti-apoptotic proteins such as Mcl-1 has emergedas a promising strategy against hematological cancers.In this study, 34 overlapping 20-mer peptides, spanning the entire Mcl-1 protein, were adjuvantedwith cationic liposomes [8] and tested in three different mouse strains with varied MajorHistocompatibility Complex (MHC) haplotypes (FVB [H-2q], CB6F1[H-2b/d], B6CBAF1 [H-2b/k])to identify immunogenic CD4+ T-cell epitopes.

UR - http://www.5z.com/24APS/24APS.2015.262

M3 - Article in proceedings

SP - 262

EP - 263

BT - Proceedings of the 24th American Peptide Symposium Ved Srivastava, Andrei Yudin, and Michal Lebl (Editors) American Peptide Society

ER -

ID: 141470253