Impact of routine vaccination with a conjugate Haemophilus influenzae type b vaccine
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Impact of routine vaccination with a conjugate Haemophilus influenzae type b vaccine. / Hviid, Anders; Melbye, Mads.
In: Vaccine, Vol. 22, No. 3-4, 02.01.2004, p. 378-382.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of routine vaccination with a conjugate Haemophilus influenzae type b vaccine
AU - Hviid, Anders
AU - Melbye, Mads
PY - 2004/1/2
Y1 - 2004/1/2
N2 - Based on a unique nationwide registration of vaccinated children, we studied the impact of routine Hib vaccination with special emphasis on vaccine uptake and adherence, vaccine effectiveness with respect to Hib meningitis, and indirect effects with respect to Hib meningitis among the unvaccinated children. Uptake and adherence was generally satisfactory. We estimated >97% effectiveness for all three doses of vaccine and observed herd-immunity in unvaccinated children comparable to a vaccine effectiveness of 94% 3.5 years into the programme. In conclusion, nationwide routine Hib vaccination is highly effective in protecting against Hib meningitis, and rapid achievement of herd immunity is possible with catch-up vaccination of older children.
AB - Based on a unique nationwide registration of vaccinated children, we studied the impact of routine Hib vaccination with special emphasis on vaccine uptake and adherence, vaccine effectiveness with respect to Hib meningitis, and indirect effects with respect to Hib meningitis among the unvaccinated children. Uptake and adherence was generally satisfactory. We estimated >97% effectiveness for all three doses of vaccine and observed herd-immunity in unvaccinated children comparable to a vaccine effectiveness of 94% 3.5 years into the programme. In conclusion, nationwide routine Hib vaccination is highly effective in protecting against Hib meningitis, and rapid achievement of herd immunity is possible with catch-up vaccination of older children.
KW - Epidemiology
KW - Haemophilus influenzae type b
KW - Vaccination
UR - http://www.scopus.com/inward/record.url?scp=0345096577&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2003.08.001
DO - 10.1016/j.vaccine.2003.08.001
M3 - Journal article
C2 - 14670319
AN - SCOPUS:0345096577
VL - 22
SP - 378
EP - 382
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 3-4
ER -
ID: 259460095