In Vivo Radionuclide Generators for Diagnostics and Therapy

Research output: Contribution to journal › Journal article › Research › peer-review

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In Vivo Radionuclide Generators for Diagnostics and Therapy. / Edem, Patricia E; Fonslet, Jesper; Kjær, Andreas; Herth, Matthias; Severin, Gregory.

In: Bioinorganic Chemistry and Applications, Vol. 2016, 6148357, 2016, p. 1-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Edem, PE, Fonslet, J, Kjær, A, Herth, M & Severin, G 2016, 'In Vivo Radionuclide Generators for Diagnostics and Therapy', Bioinorganic Chemistry and Applications, vol. 2016, 6148357, pp. 1-9. https://doi.org/10.1155/2016/6148357

APA

Edem, P. E., Fonslet, J., Kjær, A., Herth, M., & Severin, G. (2016). In Vivo Radionuclide Generators for Diagnostics and Therapy. Bioinorganic Chemistry and Applications, 2016, 1-9. [6148357]. https://doi.org/10.1155/2016/6148357

Vancouver

Edem PE, Fonslet J, Kjær A, Herth M, Severin G. In Vivo Radionuclide Generators for Diagnostics and Therapy. Bioinorganic Chemistry and Applications. 2016;2016:1-9. 6148357. https://doi.org/10.1155/2016/6148357

Author

Edem, Patricia E ; Fonslet, Jesper ; Kjær, Andreas ; Herth, Matthias ; Severin, Gregory. / In Vivo Radionuclide Generators for Diagnostics and Therapy. In: Bioinorganic Chemistry and Applications. 2016 ; Vol. 2016. pp. 1-9.

Bibtex

@article{d9a9755546c240b888145943a92d27f1,
title = "In Vivo Radionuclide Generators for Diagnostics and Therapy",
abstract = "In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is (212)Pb/(212)Bi, which takes advantage of the extended half-life of (212)Pb to execute a targeted delivery of the therapeutic short-lived α-emitter (212)Bi. Often, as in the case of (81)Rb/(81)Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.",
author = "Edem, {Patricia E} and Jesper Fonslet and Andreas Kj{\ae}r and Matthias Herth and Gregory Severin",
year = "2016",
doi = "10.1155/2016/6148357",
language = "English",
volume = "2016",
pages = "1--9",
journal = "Bioinorganic Chemistry and Applications",
issn = "1565-3633",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - In Vivo Radionuclide Generators for Diagnostics and Therapy

AU - Edem, Patricia E

AU - Fonslet, Jesper

AU - Kjær, Andreas

AU - Herth, Matthias

AU - Severin, Gregory

PY - 2016

Y1 - 2016

N2 - In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is (212)Pb/(212)Bi, which takes advantage of the extended half-life of (212)Pb to execute a targeted delivery of the therapeutic short-lived α-emitter (212)Bi. Often, as in the case of (81)Rb/(81)Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.

AB - In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is (212)Pb/(212)Bi, which takes advantage of the extended half-life of (212)Pb to execute a targeted delivery of the therapeutic short-lived α-emitter (212)Bi. Often, as in the case of (81)Rb/(81)Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.

U2 - 10.1155/2016/6148357

DO - 10.1155/2016/6148357

M3 - Journal article

C2 - 28058040

VL - 2016

SP - 1

EP - 9

JO - Bioinorganic Chemistry and Applications

JF - Bioinorganic Chemistry and Applications

SN - 1565-3633

M1 - 6148357

ER -

ID: 172098994