Increased Antioxidant Capacity and Pro-Homeostatic Lipid Mediators in Ocular Hypertension-A Human Experimental Model

Research output: Contribution to journal › Journal article › Research › peer-review

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Increased Antioxidant Capacity and Pro-Homeostatic Lipid Mediators in Ocular Hypertension-A Human Experimental Model. / Langbol, Mia; Saruhanian, Sarkis; Baskaran, Thisayini; Tiedemann, Daniel; Mouhammad, Zaynab A.; Toft-Kehler, Anne Katrine; Jun, Bokkyoo; Vohra, Rupali; Bazan, Nicolas G.; Kolko, Miriam.

In: Journal of Clinical Medicine, Vol. 9, No. 9, 2979, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Langbol, M, Saruhanian, S, Baskaran, T, Tiedemann, D, Mouhammad, ZA, Toft-Kehler, AK, Jun, B, Vohra, R, Bazan, NG & Kolko, M 2020, 'Increased Antioxidant Capacity and Pro-Homeostatic Lipid Mediators in Ocular Hypertension-A Human Experimental Model', Journal of Clinical Medicine, vol. 9, no. 9, 2979. https://doi.org/10.3390/jcm9092979

APA

Langbol, M., Saruhanian, S., Baskaran, T., Tiedemann, D., Mouhammad, Z. A., Toft-Kehler, A. K., Jun, B., Vohra, R., Bazan, N. G., & Kolko, M. (2020). Increased Antioxidant Capacity and Pro-Homeostatic Lipid Mediators in Ocular Hypertension-A Human Experimental Model. Journal of Clinical Medicine, 9(9), [2979]. https://doi.org/10.3390/jcm9092979

Vancouver

Langbol M, Saruhanian S, Baskaran T, Tiedemann D, Mouhammad ZA, Toft-Kehler AK et al. Increased Antioxidant Capacity and Pro-Homeostatic Lipid Mediators in Ocular Hypertension-A Human Experimental Model. Journal of Clinical Medicine. 2020;9(9). 2979. https://doi.org/10.3390/jcm9092979

Author

Langbol, Mia ; Saruhanian, Sarkis ; Baskaran, Thisayini ; Tiedemann, Daniel ; Mouhammad, Zaynab A. ; Toft-Kehler, Anne Katrine ; Jun, Bokkyoo ; Vohra, Rupali ; Bazan, Nicolas G. ; Kolko, Miriam. / Increased Antioxidant Capacity and Pro-Homeostatic Lipid Mediators in Ocular Hypertension-A Human Experimental Model. In: Journal of Clinical Medicine. 2020 ; Vol. 9, No. 9.

Bibtex

@article{83cc653ed4f74a5e803a0c0f258c061e,
title = "Increased Antioxidant Capacity and Pro-Homeostatic Lipid Mediators in Ocular Hypertension-A Human Experimental Model",
abstract = "The main risk factor for primary open-angle glaucoma (POAG) is increased intraocular pressure (IOP). It is of interest that about half of the patients have an IOP within the normal range (normal-tension glaucoma, NTG). Additionally, there is a group of patients with a high IOP but no glaucomatous neurodegeneration (ocular hypertension, OHT). Therefore, risk factors other than IOP are involved in the pathogenesis of glaucoma. Since the retina has a very high oxygen-demand, decreased autoregulation and a fluctuating oxygen supply to the retina have been linked to glaucomatous neurodegeneration. To assess the significance of these mechanisms, we have utilized a human experimental model, in which we stress participants with a fluctuating oxygen supply. Levels of oxidative stress molecules, antioxidants, and lipid mediators were measured in the plasma. Patients with NTG, OHT, and control subjects were found to have similar levels of oxidative stress markers. In contrast, patients with OHT had a higher level of total antioxidant capacity (TAC) and pro-homeostatic lipid mediators. Thus, we suggest that OHT patients manage fluctuating oxygen levels more efficiently and, thus, are less susceptible to glaucomatous neurodegenerations, due to enhanced systemic antioxidant protection.",
keywords = "antioxidant capacity, oxidative stress, normal-tension glaucoma, ocular hypertension, hypoxia, lipidomics, pro-homeostatic lipid mediators, hydroxyeicosatetraenoic acids, hydroxydocosahexaenoic acids, OXIDATIVE STRESS MARKERS, TRABECULAR MESHWORK CELLS, NORMAL-TENSION GLAUCOMA, OPEN-ANGLE GLAUCOMA, RED-BLOOD-CELLS, AQUEOUS-HUMOR, VENTILATORY RESPONSE, DNA-DAMAGE, HYPOXIA, ASSOCIATION",
author = "Mia Langbol and Sarkis Saruhanian and Thisayini Baskaran and Daniel Tiedemann and Mouhammad, {Zaynab A.} and Toft-Kehler, {Anne Katrine} and Bokkyoo Jun and Rupali Vohra and Bazan, {Nicolas G.} and Miriam Kolko",
year = "2020",
doi = "10.3390/jcm9092979",
language = "English",
volume = "9",
journal = "Journal of Clinical Medicine",
issn = "2077-0383",
publisher = "M D P I AG",
number = "9",

}

RIS

TY - JOUR

T1 - Increased Antioxidant Capacity and Pro-Homeostatic Lipid Mediators in Ocular Hypertension-A Human Experimental Model

AU - Langbol, Mia

AU - Saruhanian, Sarkis

AU - Baskaran, Thisayini

AU - Tiedemann, Daniel

AU - Mouhammad, Zaynab A.

AU - Toft-Kehler, Anne Katrine

AU - Jun, Bokkyoo

AU - Vohra, Rupali

AU - Bazan, Nicolas G.

AU - Kolko, Miriam

PY - 2020

Y1 - 2020

N2 - The main risk factor for primary open-angle glaucoma (POAG) is increased intraocular pressure (IOP). It is of interest that about half of the patients have an IOP within the normal range (normal-tension glaucoma, NTG). Additionally, there is a group of patients with a high IOP but no glaucomatous neurodegeneration (ocular hypertension, OHT). Therefore, risk factors other than IOP are involved in the pathogenesis of glaucoma. Since the retina has a very high oxygen-demand, decreased autoregulation and a fluctuating oxygen supply to the retina have been linked to glaucomatous neurodegeneration. To assess the significance of these mechanisms, we have utilized a human experimental model, in which we stress participants with a fluctuating oxygen supply. Levels of oxidative stress molecules, antioxidants, and lipid mediators were measured in the plasma. Patients with NTG, OHT, and control subjects were found to have similar levels of oxidative stress markers. In contrast, patients with OHT had a higher level of total antioxidant capacity (TAC) and pro-homeostatic lipid mediators. Thus, we suggest that OHT patients manage fluctuating oxygen levels more efficiently and, thus, are less susceptible to glaucomatous neurodegenerations, due to enhanced systemic antioxidant protection.

AB - The main risk factor for primary open-angle glaucoma (POAG) is increased intraocular pressure (IOP). It is of interest that about half of the patients have an IOP within the normal range (normal-tension glaucoma, NTG). Additionally, there is a group of patients with a high IOP but no glaucomatous neurodegeneration (ocular hypertension, OHT). Therefore, risk factors other than IOP are involved in the pathogenesis of glaucoma. Since the retina has a very high oxygen-demand, decreased autoregulation and a fluctuating oxygen supply to the retina have been linked to glaucomatous neurodegeneration. To assess the significance of these mechanisms, we have utilized a human experimental model, in which we stress participants with a fluctuating oxygen supply. Levels of oxidative stress molecules, antioxidants, and lipid mediators were measured in the plasma. Patients with NTG, OHT, and control subjects were found to have similar levels of oxidative stress markers. In contrast, patients with OHT had a higher level of total antioxidant capacity (TAC) and pro-homeostatic lipid mediators. Thus, we suggest that OHT patients manage fluctuating oxygen levels more efficiently and, thus, are less susceptible to glaucomatous neurodegenerations, due to enhanced systemic antioxidant protection.

KW - antioxidant capacity

KW - oxidative stress

KW - normal-tension glaucoma

KW - ocular hypertension

KW - hypoxia

KW - lipidomics

KW - pro-homeostatic lipid mediators

KW - hydroxyeicosatetraenoic acids

KW - hydroxydocosahexaenoic acids

KW - OXIDATIVE STRESS MARKERS

KW - TRABECULAR MESHWORK CELLS

KW - NORMAL-TENSION GLAUCOMA

KW - OPEN-ANGLE GLAUCOMA

KW - RED-BLOOD-CELLS

KW - AQUEOUS-HUMOR

KW - VENTILATORY RESPONSE

KW - DNA-DAMAGE

KW - HYPOXIA

KW - ASSOCIATION

U2 - 10.3390/jcm9092979

DO - 10.3390/jcm9092979

M3 - Journal article

C2 - 32942740

VL - 9

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

SN - 2077-0383

IS - 9

M1 - 2979

ER -

ID: 254731760