Inhibition by amiloride and by Na-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells

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Standard

Inhibition by amiloride and by Na-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells. / Linnebjerg, H.; Hansen, Harald S.; Jensen, B.

In: F E B S Letters, Vol. 240, No. 1-2, 21.11.1988, p. 167-170.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Linnebjerg, H, Hansen, HS & Jensen, B 1988, 'Inhibition by amiloride and by Na-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells', F E B S Letters, vol. 240, no. 1-2, pp. 167-170.

APA

Linnebjerg, H., Hansen, H. S., & Jensen, B. (1988). Inhibition by amiloride and by Na-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells. F E B S Letters, 240(1-2), 167-170.

Vancouver

Linnebjerg H, Hansen HS, Jensen B. Inhibition by amiloride and by Na-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells. F E B S Letters. 1988 Nov 21;240(1-2):167-170.

Author

Linnebjerg, H. ; Hansen, Harald S. ; Jensen, B. / Inhibition by amiloride and by Na-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells. In: F E B S Letters. 1988 ; Vol. 240, No. 1-2. pp. 167-170.

Bibtex

@article{53e9cb71754d4318b39990af85ae8a9d,
title = "Inhibition by amiloride and by Na-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells",
abstract = "Rat peritoneal mast cells, labelled with [C]arachidonic acid, released histamine and [C]arachidonic acid upon the addition of A23187. The release induced by low concentrations of A23187 was suppressed by removal of extracellular Na and by addition of the Na/H exchange inhibitor, amiloride. Addition of protein kinase C inhibitors resulted in only a modest decrease of [C]arachidonic acid and histamine release. [C]Arachidonic acid was hydrolyzed from both phosphatidylcholine and triacylglycerol. Amiloride inhibited only the hydrolysis from phosphatidylcholine. It is suggested that an Na/H exchange is stimulated secondary to an A23187-induced increase in intracellular calcium concentration. Increased Na/H exchange seems to facilitate the activation by intracellular calcium ions of phospholipase A as well as of histamine secretion.",
author = "H. Linnebjerg and Hansen, {Harald S.} and B. Jensen",
year = "1988",
month = nov,
day = "21",
language = "English",
volume = "240",
pages = "167--170",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "1-2",

}

RIS

TY - JOUR

T1 - Inhibition by amiloride and by Na-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells

AU - Linnebjerg, H.

AU - Hansen, Harald S.

AU - Jensen, B.

PY - 1988/11/21

Y1 - 1988/11/21

N2 - Rat peritoneal mast cells, labelled with [C]arachidonic acid, released histamine and [C]arachidonic acid upon the addition of A23187. The release induced by low concentrations of A23187 was suppressed by removal of extracellular Na and by addition of the Na/H exchange inhibitor, amiloride. Addition of protein kinase C inhibitors resulted in only a modest decrease of [C]arachidonic acid and histamine release. [C]Arachidonic acid was hydrolyzed from both phosphatidylcholine and triacylglycerol. Amiloride inhibited only the hydrolysis from phosphatidylcholine. It is suggested that an Na/H exchange is stimulated secondary to an A23187-induced increase in intracellular calcium concentration. Increased Na/H exchange seems to facilitate the activation by intracellular calcium ions of phospholipase A as well as of histamine secretion.

AB - Rat peritoneal mast cells, labelled with [C]arachidonic acid, released histamine and [C]arachidonic acid upon the addition of A23187. The release induced by low concentrations of A23187 was suppressed by removal of extracellular Na and by addition of the Na/H exchange inhibitor, amiloride. Addition of protein kinase C inhibitors resulted in only a modest decrease of [C]arachidonic acid and histamine release. [C]Arachidonic acid was hydrolyzed from both phosphatidylcholine and triacylglycerol. Amiloride inhibited only the hydrolysis from phosphatidylcholine. It is suggested that an Na/H exchange is stimulated secondary to an A23187-induced increase in intracellular calcium concentration. Increased Na/H exchange seems to facilitate the activation by intracellular calcium ions of phospholipase A as well as of histamine secretion.

UR - http://www.scopus.com/inward/record.url?scp=0024209994&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0024209994

VL - 240

SP - 167

EP - 170

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 1-2

ER -

ID: 45561729