Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research

Research output: Contribution to journal › Journal article › Research › peer-review

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Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research. / Celis, Julio E; Gromov, Pavel; Gromova, Irina; Moreira, José Manuel Alfonso; Cabezón, Teresa; Ambartsumian, Noona; Grigorian, Mariam; Lukanidin, Eugene; Thor Straten, Per; Guldberg, Per; Bartkova, Jirina; Bartek, Jiri; Lukas, Jiri; Lukas, Claudia; Lykkesfeldt, Anne; Jäättelä, Marja; Roepstorff, Peter; Bolund, Lars; Ørntoft, Torben Falck; Brünner, Nils; Overgaard, Jens; Sandelin, Kerstin; Blichert-Toft, Mogens; Mouridsen, Henning; Rank, Fritz E.

In: Molecular and Cellular Proteomics, Vol. 2, No. 6, 2003, p. 369-377.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Celis, JE, Gromov, P, Gromova, I, Moreira, JMA, Cabezón, T, Ambartsumian, N, Grigorian, M, Lukanidin, E, Thor Straten, P, Guldberg, P, Bartkova, J, Bartek, J, Lukas, J, Lukas, C, Lykkesfeldt, A, Jäättelä, M, Roepstorff, P, Bolund, L, Ørntoft, TF, Brünner, N, Overgaard, J, Sandelin, K, Blichert-Toft, M, Mouridsen, H & Rank, FE 2003, 'Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research', Molecular and Cellular Proteomics, vol. 2, no. 6, pp. 369-377. https://doi.org/10.1074/mcp.R300007-MCP200

APA

Celis, J. E., Gromov, P., Gromova, I., Moreira, J. M. A., Cabezón, T., Ambartsumian, N., Grigorian, M., Lukanidin, E., Thor Straten, P., Guldberg, P., Bartkova, J., Bartek, J., Lukas, J., Lukas, C., Lykkesfeldt, A., Jäättelä, M., Roepstorff, P., Bolund, L., Ørntoft, T. F., ... Rank, F. E. (2003). Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research. Molecular and Cellular Proteomics, 2(6), 369-377. https://doi.org/10.1074/mcp.R300007-MCP200

Vancouver

Celis JE, Gromov P, Gromova I, Moreira JMA, Cabezón T, Ambartsumian N et al. Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research. Molecular and Cellular Proteomics. 2003;2(6):369-377. https://doi.org/10.1074/mcp.R300007-MCP200

Author

Celis, Julio E ; Gromov, Pavel ; Gromova, Irina ; Moreira, José Manuel Alfonso ; Cabezón, Teresa ; Ambartsumian, Noona ; Grigorian, Mariam ; Lukanidin, Eugene ; Thor Straten, Per ; Guldberg, Per ; Bartkova, Jirina ; Bartek, Jiri ; Lukas, Jiri ; Lukas, Claudia ; Lykkesfeldt, Anne ; Jäättelä, Marja ; Roepstorff, Peter ; Bolund, Lars ; Ørntoft, Torben Falck ; Brünner, Nils ; Overgaard, Jens ; Sandelin, Kerstin ; Blichert-Toft, Mogens ; Mouridsen, Henning ; Rank, Fritz E. / Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research. In: Molecular and Cellular Proteomics. 2003 ; Vol. 2, No. 6. pp. 369-377.

Bibtex

@article{3ff75e90a1bd11ddb6ae000ea68e967b,
title = "Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research",
abstract = "The application of state-of-the-art proteomics and functional genomics technologies to the study of cancer is rapidly shifting toward the analysis of clinically relevant samples derived from patients, as the ultimate aim of translational research is to bring basic discoveries closer to the bedside. Here we describe the essence of a long-term initiative undertaken by The Danish Centre for Translational Breast Cancer Research and currently underway for cancer biomarker discovery using fresh tissue biopsies and bio-fluids. The Centre is a virtual hub that brings together scientists working in various areas of basic cancer research such as cell cycle control, invasion and micro-environmental alterations, apoptosis, cell signaling, and immunology, with clinicians (oncologists, surgeons), pathologists, and epidemiologists, with the aim of understanding the molecular mechanisms underlying breast cancer progression and ultimately of improving patient survival and quality of life. The unifying concept behind our approach is the use of various experimental paradigms for the prospective analysis of clinically relevant samples obtained from the same patient, along with the systematic integration of the biological and clinical data.",
keywords = "Academies and Institutes, Biomedical Research, Biopsy, Body Fluids, Breast Neoplasms, Denmark, Electrophoresis, Gel, Two-Dimensional, Female, Gene Expression Profiling, Genomics, Humans, Mammary Glands, Human, Pilot Projects, Proteomics, Specimen Handling, Tumor Markers, Biological",
author = "Celis, {Julio E} and Pavel Gromov and Irina Gromova and Moreira, {Jos{\'e} Manuel Alfonso} and Teresa Cabez{\'o}n and Noona Ambartsumian and Mariam Grigorian and Eugene Lukanidin and {Thor Straten}, Per and Per Guldberg and Jirina Bartkova and Jiri Bartek and Jiri Lukas and Claudia Lukas and Anne Lykkesfeldt and Marja J{\"a}{\"a}ttel{\"a} and Peter Roepstorff and Lars Bolund and {\O}rntoft, {Torben Falck} and Nils Br{\"u}nner and Jens Overgaard and Kerstin Sandelin and Mogens Blichert-Toft and Henning Mouridsen and Rank, {Fritz E}",
note = "Kode for udgivelsesland: 'us' Kode for bibliotekets beholdning: 'modtaget'",
year = "2003",
doi = "10.1074/mcp.R300007-MCP200",
language = "English",
volume = "2",
pages = "369--377",
journal = "Molecular and Cellular Proteomics",
issn = "1535-9476",
publisher = "American Society for Biochemistry and Molecular Biology",
number = "6",

}

RIS

TY - JOUR

T1 - Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research

AU - Celis, Julio E

AU - Gromov, Pavel

AU - Gromova, Irina

AU - Moreira, José Manuel Alfonso

AU - Cabezón, Teresa

AU - Ambartsumian, Noona

AU - Grigorian, Mariam

AU - Lukanidin, Eugene

AU - Thor Straten, Per

AU - Guldberg, Per

AU - Bartkova, Jirina

AU - Bartek, Jiri

AU - Lukas, Jiri

AU - Lukas, Claudia

AU - Lykkesfeldt, Anne

AU - Jäättelä, Marja

AU - Roepstorff, Peter

AU - Bolund, Lars

AU - Ørntoft, Torben Falck

AU - Brünner, Nils

AU - Overgaard, Jens

AU - Sandelin, Kerstin

AU - Blichert-Toft, Mogens

AU - Mouridsen, Henning

AU - Rank, Fritz E

N1 - Kode for udgivelsesland: 'us' Kode for bibliotekets beholdning: 'modtaget'

PY - 2003

Y1 - 2003

N2 - The application of state-of-the-art proteomics and functional genomics technologies to the study of cancer is rapidly shifting toward the analysis of clinically relevant samples derived from patients, as the ultimate aim of translational research is to bring basic discoveries closer to the bedside. Here we describe the essence of a long-term initiative undertaken by The Danish Centre for Translational Breast Cancer Research and currently underway for cancer biomarker discovery using fresh tissue biopsies and bio-fluids. The Centre is a virtual hub that brings together scientists working in various areas of basic cancer research such as cell cycle control, invasion and micro-environmental alterations, apoptosis, cell signaling, and immunology, with clinicians (oncologists, surgeons), pathologists, and epidemiologists, with the aim of understanding the molecular mechanisms underlying breast cancer progression and ultimately of improving patient survival and quality of life. The unifying concept behind our approach is the use of various experimental paradigms for the prospective analysis of clinically relevant samples obtained from the same patient, along with the systematic integration of the biological and clinical data.

AB - The application of state-of-the-art proteomics and functional genomics technologies to the study of cancer is rapidly shifting toward the analysis of clinically relevant samples derived from patients, as the ultimate aim of translational research is to bring basic discoveries closer to the bedside. Here we describe the essence of a long-term initiative undertaken by The Danish Centre for Translational Breast Cancer Research and currently underway for cancer biomarker discovery using fresh tissue biopsies and bio-fluids. The Centre is a virtual hub that brings together scientists working in various areas of basic cancer research such as cell cycle control, invasion and micro-environmental alterations, apoptosis, cell signaling, and immunology, with clinicians (oncologists, surgeons), pathologists, and epidemiologists, with the aim of understanding the molecular mechanisms underlying breast cancer progression and ultimately of improving patient survival and quality of life. The unifying concept behind our approach is the use of various experimental paradigms for the prospective analysis of clinically relevant samples obtained from the same patient, along with the systematic integration of the biological and clinical data.

KW - Academies and Institutes

KW - Biomedical Research

KW - Biopsy

KW - Body Fluids

KW - Breast Neoplasms

KW - Denmark

KW - Electrophoresis, Gel, Two-Dimensional

KW - Female

KW - Gene Expression Profiling

KW - Genomics

KW - Humans

KW - Mammary Glands, Human

KW - Pilot Projects

KW - Proteomics

KW - Specimen Handling

KW - Tumor Markers, Biological

U2 - 10.1074/mcp.R300007-MCP200

DO - 10.1074/mcp.R300007-MCP200

M3 - Journal article

C2 - 12832461

VL - 2

SP - 369

EP - 377

JO - Molecular and Cellular Proteomics

JF - Molecular and Cellular Proteomics

SN - 1535-9476

IS - 6

ER -

ID: 7886834