Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice

Research output: Contribution to journal › Journal article › Research › peer-review

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Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice. / Odland, Anna U.; Kristensen, Jesper L.; Andreasen, Jesper T.

In: Behavioural Brain Research, Vol. 401, 113093, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Odland, AU, Kristensen, JL & Andreasen, JT 2021, 'Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice', Behavioural Brain Research, vol. 401, 113093. https://doi.org/10.1016/j.bbr.2020.113093

APA

Odland, A. U., Kristensen, J. L., & Andreasen, J. T. (2021). Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice. Behavioural Brain Research, 401, [113093]. https://doi.org/10.1016/j.bbr.2020.113093

Vancouver

Odland AU, Kristensen JL, Andreasen JT. Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice. Behavioural Brain Research. 2021;401. 113093. https://doi.org/10.1016/j.bbr.2020.113093

Author

Odland, Anna U. ; Kristensen, Jesper L. ; Andreasen, Jesper T. / Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice. In: Behavioural Brain Research. 2021 ; Vol. 401.

Bibtex

@article{e8f8e62d2c274264a2e972c1896f4196,
title = "Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice",
abstract = "Psychedelic drugs acting as 5-hydroxyptryptamine 2A receptor (5-HT2AR) agonists have shown promise as viable treatments of psychiatric disorders, including obsessive-compulsive disorder. The marble burying test is a test of compulsive-like behavior in mice, and psychedelics acting as 5-HT2AR agonists can reduce digging in this test. We assessed the 5-HT2R contribution to the mechanisms of two 5-HT2A agonists on digging behavior in female NMRI mice, using citalopram as a reference compound. While the 5-HT2AR antagonist M100907 blocked the effect of DOI and the 5-HT2CR antagonist SB242084 blocked the effect of citalopram, neither antagonist blocked the effect of psilocybin. This study confirms 5-HT2AR agonism as a mechanism for reduced compulsive-like digging in the MB test and suggests that 5-HT2A and 5-HT2CRs can work in parallel on this type of behavior. Our results with psilocybin suggest that a 5-HT2R-independent mechanism also contributes to the effect of psilocybin on repetitive digging behavior.",
keywords = "5-HT, Compulsivity, Marble burying, Psilocybin, Serotonin",
author = "Odland, {Anna U.} and Kristensen, {Jesper L.} and Andreasen, {Jesper T.}",
year = "2021",
doi = "10.1016/j.bbr.2020.113093",
language = "English",
volume = "401",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice

AU - Odland, Anna U.

AU - Kristensen, Jesper L.

AU - Andreasen, Jesper T.

PY - 2021

Y1 - 2021

N2 - Psychedelic drugs acting as 5-hydroxyptryptamine 2A receptor (5-HT2AR) agonists have shown promise as viable treatments of psychiatric disorders, including obsessive-compulsive disorder. The marble burying test is a test of compulsive-like behavior in mice, and psychedelics acting as 5-HT2AR agonists can reduce digging in this test. We assessed the 5-HT2R contribution to the mechanisms of two 5-HT2A agonists on digging behavior in female NMRI mice, using citalopram as a reference compound. While the 5-HT2AR antagonist M100907 blocked the effect of DOI and the 5-HT2CR antagonist SB242084 blocked the effect of citalopram, neither antagonist blocked the effect of psilocybin. This study confirms 5-HT2AR agonism as a mechanism for reduced compulsive-like digging in the MB test and suggests that 5-HT2A and 5-HT2CRs can work in parallel on this type of behavior. Our results with psilocybin suggest that a 5-HT2R-independent mechanism also contributes to the effect of psilocybin on repetitive digging behavior.

AB - Psychedelic drugs acting as 5-hydroxyptryptamine 2A receptor (5-HT2AR) agonists have shown promise as viable treatments of psychiatric disorders, including obsessive-compulsive disorder. The marble burying test is a test of compulsive-like behavior in mice, and psychedelics acting as 5-HT2AR agonists can reduce digging in this test. We assessed the 5-HT2R contribution to the mechanisms of two 5-HT2A agonists on digging behavior in female NMRI mice, using citalopram as a reference compound. While the 5-HT2AR antagonist M100907 blocked the effect of DOI and the 5-HT2CR antagonist SB242084 blocked the effect of citalopram, neither antagonist blocked the effect of psilocybin. This study confirms 5-HT2AR agonism as a mechanism for reduced compulsive-like digging in the MB test and suggests that 5-HT2A and 5-HT2CRs can work in parallel on this type of behavior. Our results with psilocybin suggest that a 5-HT2R-independent mechanism also contributes to the effect of psilocybin on repetitive digging behavior.

KW - 5-HT

KW - Compulsivity

KW - Marble burying

KW - Psilocybin

KW - Serotonin

U2 - 10.1016/j.bbr.2020.113093

DO - 10.1016/j.bbr.2020.113093

M3 - Journal article

C2 - 33359368

AN - SCOPUS:85098673021

VL - 401

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

M1 - 113093

ER -

ID: 257024666