Is there a relationship between sweet taste and seizures? Anticonvulsant and proconvulsant effects of non-nutritive sweeteners

Research output: Contribution to journal › Journal article › Research › peer-review

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Is there a relationship between sweet taste and seizures? Anticonvulsant and proconvulsant effects of non-nutritive sweeteners. / Di Ianni, Mauricio E.; Enrique, Andrea V.; Del Valle, María E.; Aldana, Blanca; Rosella, María A.; Rocha, Luisa; Castro, Eduardo A.; Bruno-Blanch, Luis E.; Talevi, Alan.

In: Combinatorial Chemistry and High Throughput Screening, Vol. 18, No. 4, 2015, p. 335-345.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Di Ianni, ME, Enrique, AV, Del Valle, ME, Aldana, B, Rosella, MA, Rocha, L, Castro, EA, Bruno-Blanch, LE & Talevi, A 2015, 'Is there a relationship between sweet taste and seizures? Anticonvulsant and proconvulsant effects of non-nutritive sweeteners', Combinatorial Chemistry and High Throughput Screening, vol. 18, no. 4, pp. 335-345. https://doi.org/10.2174/1386207318666150305154210

APA

Di Ianni, M. E., Enrique, A. V., Del Valle, M. E., Aldana, B., Rosella, M. A., Rocha, L., Castro, E. A., Bruno-Blanch, L. E., & Talevi, A. (2015). Is there a relationship between sweet taste and seizures? Anticonvulsant and proconvulsant effects of non-nutritive sweeteners. Combinatorial Chemistry and High Throughput Screening, 18(4), 335-345. https://doi.org/10.2174/1386207318666150305154210

Vancouver

Di Ianni ME, Enrique AV, Del Valle ME, Aldana B, Rosella MA, Rocha L et al. Is there a relationship between sweet taste and seizures? Anticonvulsant and proconvulsant effects of non-nutritive sweeteners. Combinatorial Chemistry and High Throughput Screening. 2015;18(4):335-345. https://doi.org/10.2174/1386207318666150305154210

Author

Di Ianni, Mauricio E. ; Enrique, Andrea V. ; Del Valle, María E. ; Aldana, Blanca ; Rosella, María A. ; Rocha, Luisa ; Castro, Eduardo A. ; Bruno-Blanch, Luis E. ; Talevi, Alan. / Is there a relationship between sweet taste and seizures? Anticonvulsant and proconvulsant effects of non-nutritive sweeteners. In: Combinatorial Chemistry and High Throughput Screening. 2015 ; Vol. 18, No. 4. pp. 335-345.

Bibtex

@article{68e72c00db63497db3ce6a65b84403c1,
title = "Is there a relationship between sweet taste and seizures? Anticonvulsant and proconvulsant effects of non-nutritive sweeteners",
abstract = "From a virtual screening campaign, a number of artificial and natural sweeteners were predicted as potential anticonvulsant agents with protective effects in the seizure animal model Maximal Electroshock Seizure (MES) test. In all cases, the predictions were experimentally confirmed in the aforementioned preclinical seizure model. The article reviews and expands previous reports from our group on anticonvulsant activity of those non-nutritive sweeteners, illustrating the potential of virtual screening approaches to propose new medical uses of food additives. This constitutes a particular case of knowledge-based drug repositioning, which may greatly shorten the development time and investment required to introduce novel medications to the pharmaceutical market. We also briefly overview evidence on possible molecular explanations on the anticonvulsant and proconvulsant effects of different non-nutritive sweeteners. Our analysis based on Swanson's ABC model- suggests that group I metabotropic glutamate receptors and carbonic anhydrase isoform VII (both proposed or validated molecular targets of antiepileptic drugs) might be involved in the anticonvulsant effect of artificial sweeteners. The first hypothesis is in line with recent advances on development of selective modulators of group I metabotropic glutamate receptors as potential antiepileptic agents.",
keywords = "Convulsions, Drug repositioning, Epilepsy, Maximal electroshock seizures, Non-nutritive sweeteners, Pentylenetetrazol, Stevia, Stevia rebaudiana, Steviosides, Swanson's ABC model, Virtual screening",
author = "{Di Ianni}, {Mauricio E.} and Enrique, {Andrea V.} and {Del Valle}, {Mar{\'i}a E.} and Blanca Aldana and Rosella, {Mar{\'i}a A.} and Luisa Rocha and Castro, {Eduardo A.} and Bruno-Blanch, {Luis E.} and Alan Talevi",
year = "2015",
doi = "10.2174/1386207318666150305154210",
language = "English",
volume = "18",
pages = "335--345",
journal = "Combinatorial Chemistry & High Throughput Screening",
issn = "1386-2073",
publisher = "Bentham Science Publishers",
number = "4",

}

RIS

TY - JOUR

T1 - Is there a relationship between sweet taste and seizures? Anticonvulsant and proconvulsant effects of non-nutritive sweeteners

AU - Di Ianni, Mauricio E.

AU - Enrique, Andrea V.

AU - Del Valle, María E.

AU - Aldana, Blanca

AU - Rosella, María A.

AU - Rocha, Luisa

AU - Castro, Eduardo A.

AU - Bruno-Blanch, Luis E.

AU - Talevi, Alan

PY - 2015

Y1 - 2015

N2 - From a virtual screening campaign, a number of artificial and natural sweeteners were predicted as potential anticonvulsant agents with protective effects in the seizure animal model Maximal Electroshock Seizure (MES) test. In all cases, the predictions were experimentally confirmed in the aforementioned preclinical seizure model. The article reviews and expands previous reports from our group on anticonvulsant activity of those non-nutritive sweeteners, illustrating the potential of virtual screening approaches to propose new medical uses of food additives. This constitutes a particular case of knowledge-based drug repositioning, which may greatly shorten the development time and investment required to introduce novel medications to the pharmaceutical market. We also briefly overview evidence on possible molecular explanations on the anticonvulsant and proconvulsant effects of different non-nutritive sweeteners. Our analysis based on Swanson's ABC model- suggests that group I metabotropic glutamate receptors and carbonic anhydrase isoform VII (both proposed or validated molecular targets of antiepileptic drugs) might be involved in the anticonvulsant effect of artificial sweeteners. The first hypothesis is in line with recent advances on development of selective modulators of group I metabotropic glutamate receptors as potential antiepileptic agents.

AB - From a virtual screening campaign, a number of artificial and natural sweeteners were predicted as potential anticonvulsant agents with protective effects in the seizure animal model Maximal Electroshock Seizure (MES) test. In all cases, the predictions were experimentally confirmed in the aforementioned preclinical seizure model. The article reviews and expands previous reports from our group on anticonvulsant activity of those non-nutritive sweeteners, illustrating the potential of virtual screening approaches to propose new medical uses of food additives. This constitutes a particular case of knowledge-based drug repositioning, which may greatly shorten the development time and investment required to introduce novel medications to the pharmaceutical market. We also briefly overview evidence on possible molecular explanations on the anticonvulsant and proconvulsant effects of different non-nutritive sweeteners. Our analysis based on Swanson's ABC model- suggests that group I metabotropic glutamate receptors and carbonic anhydrase isoform VII (both proposed or validated molecular targets of antiepileptic drugs) might be involved in the anticonvulsant effect of artificial sweeteners. The first hypothesis is in line with recent advances on development of selective modulators of group I metabotropic glutamate receptors as potential antiepileptic agents.

KW - Convulsions

KW - Drug repositioning

KW - Epilepsy

KW - Maximal electroshock seizures

KW - Non-nutritive sweeteners

KW - Pentylenetetrazol

KW - Stevia

KW - Stevia rebaudiana

KW - Steviosides

KW - Swanson's ABC model

KW - Virtual screening

UR - http://www.scopus.com/inward/record.url?scp=84931273863&partnerID=8YFLogxK

U2 - 10.2174/1386207318666150305154210

DO - 10.2174/1386207318666150305154210

M3 - Journal article

C2 - 25747439

AN - SCOPUS:84931273863

VL - 18

SP - 335

EP - 345

JO - Combinatorial Chemistry & High Throughput Screening

JF - Combinatorial Chemistry & High Throughput Screening

SN - 1386-2073

IS - 4

ER -

ID: 260188124