Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. / Jäger, Anna; Petersen, K N; Thomasen, G.; Christensen, S Brøgger.

In: Phytotherapy Research, Vol. 22, No. 7, 2008, p. 982-984.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jäger, A, Petersen, KN, Thomasen, G & Christensen, SB 2008, 'Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip', Phytotherapy Research, vol. 22, no. 7, pp. 982-984. https://doi.org/10.1002/ptr.2446

APA

Jäger, A., Petersen, K. N., Thomasen, G., & Christensen, S. B. (2008). Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. Phytotherapy Research, 22(7), 982-984. https://doi.org/10.1002/ptr.2446

Vancouver

Jäger A, Petersen KN, Thomasen G, Christensen SB. Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. Phytotherapy Research. 2008;22(7):982-984. https://doi.org/10.1002/ptr.2446

Author

Jäger, Anna ; Petersen, K N ; Thomasen, G. ; Christensen, S Brøgger. / Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. In: Phytotherapy Research. 2008 ; Vol. 22, No. 7. pp. 982-984.

Bibtex

@article{edc1b8e05a3711dd8d9f000ea68e967b,
title = "Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip",
abstract = "Rose hip has previously shown clinical efficacy in the treatment of osteoarthritis, and organic solvent extracts of rose hip have showed inhibition of cyclooxygenase-1 and -2. A petroleum ether extract of rose hip was fractioned by VLC on silica; on a C-18 column and by HPLC. Each step was COX-1/2 activity-guided. The bioassay-guided fractionation led to the isolation of linoleic acid (the IC50 for COX-1 was 85 microm and 0.6 microM for COX-2) and alpha-linolenic acid (the IC50 for COX-1 was 52 microM and 12 microM for COX-2). The COX-2/COX-1 ratio was 0.007 for linoleic acid and 0.2 for alpha-linolenic acid. Linoleic acid and alpha-linolenic acid contribute to the COX-1 and -2 inhibitory activity of rose hip.",
keywords = "Chromatography, High Pressure Liquid, Cyclooxygenase 2 Inhibitors, Humans, Linoleic Acid, Osteoarthritis, Phytotherapy, Plant Extracts, Rosa, Vacuum, alpha-Linolenic Acid",
author = "Anna J{\"a}ger and Petersen, {K N} and G. Thomasen and Christensen, {S Br{\o}gger}",
note = "Keywords: cyclooxygenase; linoleic acid; a-linolenic acid; Rosa canina; rose hip",
year = "2008",
doi = "10.1002/ptr.2446",
language = "English",
volume = "22",
pages = "982--984",
journal = "Phytotherapy Research",
issn = "0951-418X",
publisher = "JohnWiley & Sons Ltd",
number = "7",

}

RIS

TY - JOUR

T1 - Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip

AU - Jäger, Anna

AU - Petersen, K N

AU - Thomasen, G.

AU - Christensen, S Brøgger

N1 - Keywords: cyclooxygenase; linoleic acid; a-linolenic acid; Rosa canina; rose hip

PY - 2008

Y1 - 2008

N2 - Rose hip has previously shown clinical efficacy in the treatment of osteoarthritis, and organic solvent extracts of rose hip have showed inhibition of cyclooxygenase-1 and -2. A petroleum ether extract of rose hip was fractioned by VLC on silica; on a C-18 column and by HPLC. Each step was COX-1/2 activity-guided. The bioassay-guided fractionation led to the isolation of linoleic acid (the IC50 for COX-1 was 85 microm and 0.6 microM for COX-2) and alpha-linolenic acid (the IC50 for COX-1 was 52 microM and 12 microM for COX-2). The COX-2/COX-1 ratio was 0.007 for linoleic acid and 0.2 for alpha-linolenic acid. Linoleic acid and alpha-linolenic acid contribute to the COX-1 and -2 inhibitory activity of rose hip.

AB - Rose hip has previously shown clinical efficacy in the treatment of osteoarthritis, and organic solvent extracts of rose hip have showed inhibition of cyclooxygenase-1 and -2. A petroleum ether extract of rose hip was fractioned by VLC on silica; on a C-18 column and by HPLC. Each step was COX-1/2 activity-guided. The bioassay-guided fractionation led to the isolation of linoleic acid (the IC50 for COX-1 was 85 microm and 0.6 microM for COX-2) and alpha-linolenic acid (the IC50 for COX-1 was 52 microM and 12 microM for COX-2). The COX-2/COX-1 ratio was 0.007 for linoleic acid and 0.2 for alpha-linolenic acid. Linoleic acid and alpha-linolenic acid contribute to the COX-1 and -2 inhibitory activity of rose hip.

KW - Chromatography, High Pressure Liquid

KW - Cyclooxygenase 2 Inhibitors

KW - Humans

KW - Linoleic Acid

KW - Osteoarthritis

KW - Phytotherapy

KW - Plant Extracts

KW - Rosa

KW - Vacuum

KW - alpha-Linolenic Acid

U2 - 10.1002/ptr.2446

DO - 10.1002/ptr.2446

M3 - Journal article

C2 - 18389471

VL - 22

SP - 982

EP - 984

JO - Phytotherapy Research

JF - Phytotherapy Research

SN - 0951-418X

IS - 7

ER -

ID: 5185548