Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip
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Rose hip has previously shown clinical efficacy in the treatment of osteoarthritis, and organic solvent extracts of rose hip have showed inhibition of cyclooxygenase-1 and -2. A petroleum ether extract of rose hip was fractioned by VLC on silica; on a C-18 column and by HPLC. Each step was COX-1/2 activity-guided. The bioassay-guided fractionation led to the isolation of linoleic acid (the IC50 for COX-1 was 85 microm and 0.6 microM for COX-2) and alpha-linolenic acid (the IC50 for COX-1 was 52 microM and 12 microM for COX-2). The COX-2/COX-1 ratio was 0.007 for linoleic acid and 0.2 for alpha-linolenic acid. Linoleic acid and alpha-linolenic acid contribute to the COX-1 and -2 inhibitory activity of rose hip.
Original language | English |
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Journal | Phytotherapy Research |
Volume | 22 |
Issue number | 7 |
Pages (from-to) | 982-984 |
Number of pages | 3 |
ISSN | 0951-418X |
DOIs | |
Publication status | Published - 2008 |
Bibliographical note
Keywords: cyclooxygenase; linoleic acid; a-linolenic acid; Rosa canina; rose hip
- Chromatography, High Pressure Liquid, Cyclooxygenase 2 Inhibitors, Humans, Linoleic Acid, Osteoarthritis, Phytotherapy, Plant Extracts, Rosa, Vacuum, alpha-Linolenic Acid
Research areas
ID: 5185548