Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula. / Hassan, Ahmed R; El-Kousy, Salah M; El-Toumy, Sayed A; Frydenvang, Karla; Tung, Truong Thanh; Olsen, Jesper; Nielsen, John; Christensen, Søren Brøgger.

In: Journal of Natural Products, Vol. 80, 27.10.2017, p. 2830-2834.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hassan, AR, El-Kousy, SM, El-Toumy, SA, Frydenvang, K, Tung, TT, Olsen, J, Nielsen, J & Christensen, SB 2017, 'Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula', Journal of Natural Products, vol. 80, pp. 2830-2834. https://doi.org/10.1021/acs.jnatprod.7b00106

APA

Hassan, A. R., El-Kousy, S. M., El-Toumy, S. A., Frydenvang, K., Tung, T. T., Olsen, J., Nielsen, J., & Christensen, S. B. (2017). Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula. Journal of Natural Products, 80, 2830-2834. https://doi.org/10.1021/acs.jnatprod.7b00106

Vancouver

Hassan AR, El-Kousy SM, El-Toumy SA, Frydenvang K, Tung TT, Olsen J et al. Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula. Journal of Natural Products. 2017 Oct 27;80:2830-2834. https://doi.org/10.1021/acs.jnatprod.7b00106

Author

Hassan, Ahmed R ; El-Kousy, Salah M ; El-Toumy, Sayed A ; Frydenvang, Karla ; Tung, Truong Thanh ; Olsen, Jesper ; Nielsen, John ; Christensen, Søren Brøgger. / Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula. In: Journal of Natural Products. 2017 ; Vol. 80. pp. 2830-2834.

Bibtex

@article{27d567c6c64143fbbb3f5f16bfa89255,
title = "Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula",
abstract = "A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.",
keywords = "Journal Article",
author = "Hassan, {Ahmed R} and El-Kousy, {Salah M} and El-Toumy, {Sayed A} and Karla Frydenvang and Tung, {Truong Thanh} and Jesper Olsen and John Nielsen and Christensen, {S{\o}ren Br{\o}gger}",
year = "2017",
month = oct,
day = "27",
doi = "10.1021/acs.jnatprod.7b00106",
language = "English",
volume = "80",
pages = "2830--2834",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",

}

RIS

TY - JOUR

T1 - Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

AU - Hassan, Ahmed R

AU - El-Kousy, Salah M

AU - El-Toumy, Sayed A

AU - Frydenvang, Karla

AU - Tung, Truong Thanh

AU - Olsen, Jesper

AU - Nielsen, John

AU - Christensen, Søren Brøgger

PY - 2017/10/27

Y1 - 2017/10/27

N2 - A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

AB - A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

KW - Journal Article

U2 - 10.1021/acs.jnatprod.7b00106

DO - 10.1021/acs.jnatprod.7b00106

M3 - Journal article

C2 - 28930456

VL - 80

SP - 2830

EP - 2834

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

ER -

ID: 183701308