Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines. / Franzyk, H.; Crestey, F.; Witt, M.; Frydenvang, K.; Stærk, D.; Jaroszewski, J.

In: Synfacts, Vol. 7, 2008, p. 769.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Franzyk, H, Crestey, F, Witt, M, Frydenvang, K, Stærk, D & Jaroszewski, J 2008, 'Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines', Synfacts, vol. 7, pp. 769. https://doi.org/10.1055/s-2008-1078443

APA

Franzyk, H., Crestey, F., Witt, M., Frydenvang, K., Stærk, D., & Jaroszewski, J. (2008). Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines. Synfacts, 7, 769. https://doi.org/10.1055/s-2008-1078443

Vancouver

Franzyk H, Crestey F, Witt M, Frydenvang K, Stærk D, Jaroszewski J. Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines. Synfacts. 2008;7:769. https://doi.org/10.1055/s-2008-1078443

Author

Franzyk, H. ; Crestey, F. ; Witt, M. ; Frydenvang, K. ; Stærk, D. ; Jaroszewski, J. / Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines. In: Synfacts. 2008 ; Vol. 7. pp. 769.

Bibtex

@article{e1b062ab51a2499ea7af706de1883b9f,
title = "Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines",
abstract = "The solid-phase ring-opening of N-nosyl aziridines under microwave conditions is described. Thus, p-nitrobenzenesulfonyl (nosyl = Ns)-activated aziridines 2a-g were prepared from1,2-amino alcohols 1a-g with an excess amount of nosyl chloride (NsCl) in CH2Cl2-pyridine (2:1). The ring-opening of the aziridines 2a-g with resin-bound amines 3-5 gave the corresponding amines 6-12 in >25 to >95% yield with 63-97% purity after acidic cleavage. The glycine and proline derivatives 16-18 were also obtained from 13-15 in >95% yield with 93-97% purity.",
author = "H. Franzyk and F. Crestey and M. Witt and K. Frydenvang and D. St{\ae}rk and J. Jaroszewski",
year = "2008",
doi = "10.1055/s-2008-1078443",
language = "English",
volume = "7",
pages = "769",
journal = "Synfacts",
issn = "1861-1958",
publisher = "GeorgThieme Verlag",

}

RIS

TY - JOUR

T1 - Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines

AU - Franzyk, H.

AU - Crestey, F.

AU - Witt, M.

AU - Frydenvang, K.

AU - Stærk, D.

AU - Jaroszewski, J.

PY - 2008

Y1 - 2008

N2 - The solid-phase ring-opening of N-nosyl aziridines under microwave conditions is described. Thus, p-nitrobenzenesulfonyl (nosyl = Ns)-activated aziridines 2a-g were prepared from1,2-amino alcohols 1a-g with an excess amount of nosyl chloride (NsCl) in CH2Cl2-pyridine (2:1). The ring-opening of the aziridines 2a-g with resin-bound amines 3-5 gave the corresponding amines 6-12 in >25 to >95% yield with 63-97% purity after acidic cleavage. The glycine and proline derivatives 16-18 were also obtained from 13-15 in >95% yield with 93-97% purity.

AB - The solid-phase ring-opening of N-nosyl aziridines under microwave conditions is described. Thus, p-nitrobenzenesulfonyl (nosyl = Ns)-activated aziridines 2a-g were prepared from1,2-amino alcohols 1a-g with an excess amount of nosyl chloride (NsCl) in CH2Cl2-pyridine (2:1). The ring-opening of the aziridines 2a-g with resin-bound amines 3-5 gave the corresponding amines 6-12 in >25 to >95% yield with 63-97% purity after acidic cleavage. The glycine and proline derivatives 16-18 were also obtained from 13-15 in >95% yield with 93-97% purity.

U2 - 10.1055/s-2008-1078443

DO - 10.1055/s-2008-1078443

M3 - Journal article

VL - 7

SP - 769

JO - Synfacts

JF - Synfacts

SN - 1861-1958

ER -

ID: 147218725