Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: human cell culture studies

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain : human cell culture studies. / Bahniwal, Manpreet; Villanueva, Erika B; Klegeris, Andis.

In: Journal of Neuroimmunology, Vol. 233, No. 1-2, 04.2011, p. 65-72.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bahniwal, M, Villanueva, EB & Klegeris, A 2011, 'Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: human cell culture studies', Journal of Neuroimmunology, vol. 233, no. 1-2, pp. 65-72. https://doi.org/10.1016/j.jneuroim.2010.11.016

APA

Bahniwal, M., Villanueva, E. B., & Klegeris, A. (2011). Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: human cell culture studies. Journal of Neuroimmunology, 233(1-2), 65-72. https://doi.org/10.1016/j.jneuroim.2010.11.016

Vancouver

Bahniwal M, Villanueva EB, Klegeris A. Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: human cell culture studies. Journal of Neuroimmunology. 2011 Apr;233(1-2):65-72. https://doi.org/10.1016/j.jneuroim.2010.11.016

Author

Bahniwal, Manpreet ; Villanueva, Erika B ; Klegeris, Andis. / Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain : human cell culture studies. In: Journal of Neuroimmunology. 2011 ; Vol. 233, No. 1-2. pp. 65-72.

Bibtex

@article{27c71928d360414b8259edced6ede775,
title = "Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: human cell culture studies",
abstract = "The effect of a moderate, physiologically relevant rise in temperature on several neuroinflammatory parameters was investigated in vitro using human cell lines and cultured human astrocytes. A two degree Celsius rise in temperature was found to enhance the neurotoxicity of microglia-like and astrocytic cells, increase the release of monocyte chemotactic protein (MCP)-1 by activated human monocytic THP-1 cells and amplify the generation of reactive oxygen intermediates by differentiated HL-60 myelocytic cells. Moderate increases in body temperature may exacerbate neuroinflammation and neuronal injury in chronic neurodegenerative disorders. Hence, therapies aimed at lowering the body temperature could be used to slow down the progression of such diseases.",
keywords = "Body Temperature/immunology, Brain/immunology, Cell Culture Techniques/methods, Cells, Cultured, Fever/immunology, HL-60 Cells, Humans, Neuroimmunomodulation/immunology, Neurons/immunology",
author = "Manpreet Bahniwal and Villanueva, {Erika B} and Andis Klegeris",
note = "Crown Copyright {\textcopyright} 2010. Published by Elsevier B.V. All rights reserved.",
year = "2011",
month = apr,
doi = "10.1016/j.jneuroim.2010.11.016",
language = "English",
volume = "233",
pages = "65--72",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain

T2 - human cell culture studies

AU - Bahniwal, Manpreet

AU - Villanueva, Erika B

AU - Klegeris, Andis

N1 - Crown Copyright © 2010. Published by Elsevier B.V. All rights reserved.

PY - 2011/4

Y1 - 2011/4

N2 - The effect of a moderate, physiologically relevant rise in temperature on several neuroinflammatory parameters was investigated in vitro using human cell lines and cultured human astrocytes. A two degree Celsius rise in temperature was found to enhance the neurotoxicity of microglia-like and astrocytic cells, increase the release of monocyte chemotactic protein (MCP)-1 by activated human monocytic THP-1 cells and amplify the generation of reactive oxygen intermediates by differentiated HL-60 myelocytic cells. Moderate increases in body temperature may exacerbate neuroinflammation and neuronal injury in chronic neurodegenerative disorders. Hence, therapies aimed at lowering the body temperature could be used to slow down the progression of such diseases.

AB - The effect of a moderate, physiologically relevant rise in temperature on several neuroinflammatory parameters was investigated in vitro using human cell lines and cultured human astrocytes. A two degree Celsius rise in temperature was found to enhance the neurotoxicity of microglia-like and astrocytic cells, increase the release of monocyte chemotactic protein (MCP)-1 by activated human monocytic THP-1 cells and amplify the generation of reactive oxygen intermediates by differentiated HL-60 myelocytic cells. Moderate increases in body temperature may exacerbate neuroinflammation and neuronal injury in chronic neurodegenerative disorders. Hence, therapies aimed at lowering the body temperature could be used to slow down the progression of such diseases.

KW - Body Temperature/immunology

KW - Brain/immunology

KW - Cell Culture Techniques/methods

KW - Cells, Cultured

KW - Fever/immunology

KW - HL-60 Cells

KW - Humans

KW - Neuroimmunomodulation/immunology

KW - Neurons/immunology

U2 - 10.1016/j.jneuroim.2010.11.016

DO - 10.1016/j.jneuroim.2010.11.016

M3 - Journal article

C2 - 21185608

VL - 233

SP - 65

EP - 72

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -

ID: 236609785