Molecular modelling of GABA uptake inhibitors

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Molecular modelling of GABA uptake inhibitors. / Jørgensen, Flemming Steen; Thøgersen, Henning.

In: Nordic Journal of Psychiatry, Vol. 41, No. 6, 01.01.1987, p. 483-486.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jørgensen, FS & Thøgersen, H 1987, 'Molecular modelling of GABA uptake inhibitors', Nordic Journal of Psychiatry, vol. 41, no. 6, pp. 483-486. https://doi.org/10.3109/08039488709097043

APA

Jørgensen, F. S., & Thøgersen, H. (1987). Molecular modelling of GABA uptake inhibitors. Nordic Journal of Psychiatry, 41(6), 483-486. https://doi.org/10.3109/08039488709097043

Vancouver

Jørgensen FS, Thøgersen H. Molecular modelling of GABA uptake inhibitors. Nordic Journal of Psychiatry. 1987 Jan 1;41(6):483-486. https://doi.org/10.3109/08039488709097043

Author

Jørgensen, Flemming Steen ; Thøgersen, Henning. / Molecular modelling of GABA uptake inhibitors. In: Nordic Journal of Psychiatry. 1987 ; Vol. 41, No. 6. pp. 483-486.

Bibtex

@article{224dca9412af4205b9d86a5303068183,
title = "Molecular modelling of GABA uptake inhibitors",
abstract = "A joint molecular modelling and computer graphics study of the potent and conformatio-nally flexible GABA uptake inhibitor SKF 89.976-A is presented. Two principally different approaches for determining the biologically active conformation(s) are described. In the first approach, three flexible compounds are compared in order to find differences between the potent SKF compound, an inactive and a less active compound. In the second approach, SKF 89.976-A is compared with a conformationally constrained GABA uptake inhibitor. The results are compared and a tentative model for the recognition site deduced.",
keywords = "GABA uptake inhibitors, Molecular modelling, Omputer graphics",
author = "J{\o}rgensen, {Flemming Steen} and Henning Th{\o}gersen",
year = "1987",
month = jan,
day = "1",
doi = "10.3109/08039488709097043",
language = "English",
volume = "41",
pages = "483--486",
journal = "Nordisk Psykiatrisk Tidsskrift",
issn = "0803-9496",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - Molecular modelling of GABA uptake inhibitors

AU - Jørgensen, Flemming Steen

AU - Thøgersen, Henning

PY - 1987/1/1

Y1 - 1987/1/1

N2 - A joint molecular modelling and computer graphics study of the potent and conformatio-nally flexible GABA uptake inhibitor SKF 89.976-A is presented. Two principally different approaches for determining the biologically active conformation(s) are described. In the first approach, three flexible compounds are compared in order to find differences between the potent SKF compound, an inactive and a less active compound. In the second approach, SKF 89.976-A is compared with a conformationally constrained GABA uptake inhibitor. The results are compared and a tentative model for the recognition site deduced.

AB - A joint molecular modelling and computer graphics study of the potent and conformatio-nally flexible GABA uptake inhibitor SKF 89.976-A is presented. Two principally different approaches for determining the biologically active conformation(s) are described. In the first approach, three flexible compounds are compared in order to find differences between the potent SKF compound, an inactive and a less active compound. In the second approach, SKF 89.976-A is compared with a conformationally constrained GABA uptake inhibitor. The results are compared and a tentative model for the recognition site deduced.

KW - GABA uptake inhibitors

KW - Molecular modelling

KW - Omputer graphics

UR - http://www.scopus.com/inward/record.url?scp=0023576848&partnerID=8YFLogxK

U2 - 10.3109/08039488709097043

DO - 10.3109/08039488709097043

M3 - Journal article

AN - SCOPUS:0023576848

VL - 41

SP - 483

EP - 486

JO - Nordisk Psykiatrisk Tidsskrift

JF - Nordisk Psykiatrisk Tidsskrift

SN - 0803-9496

IS - 6

ER -

ID: 218715793