Molecular technologies for pseudo-natural peptide synthesis and discovery of bioactive compounds against undruggable targets

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Molecular technologies for pseudo-natural peptide synthesis and discovery of bioactive compounds against undruggable targets. / Rogers, Joseph M.; Suga, Hiroaki.

Molecular Technology: Materials Innovation. Wiley, 2019. p. 329-370.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Rogers, JM & Suga, H 2019, Molecular technologies for pseudo-natural peptide synthesis and discovery of bioactive compounds against undruggable targets. in Molecular Technology: Materials Innovation. Wiley, pp. 329-370. https://doi.org/10.1002/9783527823987.vol2_c15

APA

Rogers, J. M., & Suga, H. (2019). Molecular technologies for pseudo-natural peptide synthesis and discovery of bioactive compounds against undruggable targets. In Molecular Technology: Materials Innovation (pp. 329-370). Wiley. https://doi.org/10.1002/9783527823987.vol2_c15

Vancouver

Rogers JM, Suga H. Molecular technologies for pseudo-natural peptide synthesis and discovery of bioactive compounds against undruggable targets. In Molecular Technology: Materials Innovation. Wiley. 2019. p. 329-370 https://doi.org/10.1002/9783527823987.vol2_c15

Author

Rogers, Joseph M. ; Suga, Hiroaki. / Molecular technologies for pseudo-natural peptide synthesis and discovery of bioactive compounds against undruggable targets. Molecular Technology: Materials Innovation. Wiley, 2019. pp. 329-370

Bibtex

@inbook{04c7b0066c1a4c928ff39250a500e98a,
title = "Molecular technologies for pseudo-natural peptide synthesis and discovery of bioactive compounds against undruggable targets",
abstract = "Many protein targets are inherently unsuitable for binding small molecules and have been labeled {"}undruggable{"} as a result. New classes of drugs are required for these targets. Peptides can meet this need, provided that they contain certain modifications, e.g. unnatural amino acids and macrocyclic backbone structures. Such peptides are large enough to bind tightly and specifically to protein targets, including those considered undruggable. At the same time, these peptides can be small enough to be membrane permeable, be administered orally, and enter cells. Here, molecular technologies are descried that can be used to find binding peptides for essentially any given protein target. We describe how these technologies can be combined with pseudo-natural peptide synthesis, which allows for the discovery of drug-like peptides that include unnatural amino acids and macrocycles. {\textcopyright}",
keywords = "Bicyclic, Cyclosporin, Flexizyme, Genetic code expansion, Genetic code reprogramming, mRNA display, Non-proteinogenic amino acids, Phage display, RaPID system, Ribosome",
author = "Rogers, {Joseph M.} and Hiroaki Suga",
year = "2019",
month = feb,
day = "6",
doi = "10.1002/9783527823987.vol2_c15",
language = "English",
isbn = "9783527341610",
pages = "329--370",
booktitle = "Molecular Technology",
publisher = "Wiley",
address = "United States",

}

RIS

TY - CHAP

T1 - Molecular technologies for pseudo-natural peptide synthesis and discovery of bioactive compounds against undruggable targets

AU - Rogers, Joseph M.

AU - Suga, Hiroaki

PY - 2019/2/6

Y1 - 2019/2/6

N2 - Many protein targets are inherently unsuitable for binding small molecules and have been labeled "undruggable" as a result. New classes of drugs are required for these targets. Peptides can meet this need, provided that they contain certain modifications, e.g. unnatural amino acids and macrocyclic backbone structures. Such peptides are large enough to bind tightly and specifically to protein targets, including those considered undruggable. At the same time, these peptides can be small enough to be membrane permeable, be administered orally, and enter cells. Here, molecular technologies are descried that can be used to find binding peptides for essentially any given protein target. We describe how these technologies can be combined with pseudo-natural peptide synthesis, which allows for the discovery of drug-like peptides that include unnatural amino acids and macrocycles. ©

AB - Many protein targets are inherently unsuitable for binding small molecules and have been labeled "undruggable" as a result. New classes of drugs are required for these targets. Peptides can meet this need, provided that they contain certain modifications, e.g. unnatural amino acids and macrocyclic backbone structures. Such peptides are large enough to bind tightly and specifically to protein targets, including those considered undruggable. At the same time, these peptides can be small enough to be membrane permeable, be administered orally, and enter cells. Here, molecular technologies are descried that can be used to find binding peptides for essentially any given protein target. We describe how these technologies can be combined with pseudo-natural peptide synthesis, which allows for the discovery of drug-like peptides that include unnatural amino acids and macrocycles. ©

KW - Bicyclic

KW - Cyclosporin

KW - Flexizyme

KW - Genetic code expansion

KW - Genetic code reprogramming

KW - mRNA display

KW - Non-proteinogenic amino acids

KW - Phage display

KW - RaPID system

KW - Ribosome

UR - http://www.scopus.com/inward/record.url?scp=85101264109&partnerID=8YFLogxK

U2 - 10.1002/9783527823987.vol2_c15

DO - 10.1002/9783527823987.vol2_c15

M3 - Book chapter

AN - SCOPUS:85101264109

SN - 9783527341610

SP - 329

EP - 370

BT - Molecular Technology

PB - Wiley

ER -

ID: 257913621