Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking. / Denk, Christoph; Wilkovitsch, Martin; Aneheim, Emma; Herth, Matthias M.; Jensen, Holger; Lindegren, Sture; Mikula, Hannes.

In: ChemPlusChem, Vol. 219, No. 84, 01.01.2019, p. 775-778.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Denk, C, Wilkovitsch, M, Aneheim, E, Herth, MM, Jensen, H, Lindegren, S & Mikula, H 2019, 'Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking', ChemPlusChem, vol. 219, no. 84, pp. 775-778. https://doi.org/10.1002/cplu.201900114

APA

Denk, C., Wilkovitsch, M., Aneheim, E., Herth, M. M., Jensen, H., Lindegren, S., & Mikula, H. (2019). Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking. ChemPlusChem, 219(84), 775-778. https://doi.org/10.1002/cplu.201900114

Vancouver

Denk C, Wilkovitsch M, Aneheim E, Herth MM, Jensen H, Lindegren S et al. Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking. ChemPlusChem. 2019 Jan 1;219(84):775-778. https://doi.org/10.1002/cplu.201900114

Author

Denk, Christoph ; Wilkovitsch, Martin ; Aneheim, Emma ; Herth, Matthias M. ; Jensen, Holger ; Lindegren, Sture ; Mikula, Hannes. / Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking. In: ChemPlusChem. 2019 ; Vol. 219, No. 84. pp. 775-778.

Bibtex

@article{eeda7cebf14b409f8bd9de352e6254a2,
title = "Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking",
abstract = " In the past decade, several developments have expanded the chemical toolbox for astatination and the preparation of 211 At-labeled radiopharmaceuticals. However, there is still a need for advanced methods for the synthesis of astatinated (bio)molecules to address challenges such as limited in vivo stability. Herein, we report the development of multifunctional 211 At-labeled reagents that can be prepared by applying a modular and versatile click approach for rapid assembly. The introduction of tetrazines as bioorthogonal tags enables rapid radiolabeling and radio-crosslinking, which is demonstrated by steric shielding of 211 At to significantly increase label stability in human blood plasma. ",
keywords = "bioorthogonal chemistry, click chemistry, multicomponent reactions, radiochemistry, radiolabeling",
author = "Christoph Denk and Martin Wilkovitsch and Emma Aneheim and Herth, {Matthias M.} and Holger Jensen and Sture Lindegren and Hannes Mikula",
year = "2019",
month = jan,
day = "1",
doi = "10.1002/cplu.201900114",
language = "English",
volume = "219",
pages = "775--778",
journal = "ChemPlusChem",
issn = "2192-6506",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "84",

}

RIS

TY - JOUR

T1 - Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking

AU - Denk, Christoph

AU - Wilkovitsch, Martin

AU - Aneheim, Emma

AU - Herth, Matthias M.

AU - Jensen, Holger

AU - Lindegren, Sture

AU - Mikula, Hannes

PY - 2019/1/1

Y1 - 2019/1/1

N2 - In the past decade, several developments have expanded the chemical toolbox for astatination and the preparation of 211 At-labeled radiopharmaceuticals. However, there is still a need for advanced methods for the synthesis of astatinated (bio)molecules to address challenges such as limited in vivo stability. Herein, we report the development of multifunctional 211 At-labeled reagents that can be prepared by applying a modular and versatile click approach for rapid assembly. The introduction of tetrazines as bioorthogonal tags enables rapid radiolabeling and radio-crosslinking, which is demonstrated by steric shielding of 211 At to significantly increase label stability in human blood plasma.

AB - In the past decade, several developments have expanded the chemical toolbox for astatination and the preparation of 211 At-labeled radiopharmaceuticals. However, there is still a need for advanced methods for the synthesis of astatinated (bio)molecules to address challenges such as limited in vivo stability. Herein, we report the development of multifunctional 211 At-labeled reagents that can be prepared by applying a modular and versatile click approach for rapid assembly. The introduction of tetrazines as bioorthogonal tags enables rapid radiolabeling and radio-crosslinking, which is demonstrated by steric shielding of 211 At to significantly increase label stability in human blood plasma.

KW - bioorthogonal chemistry

KW - click chemistry

KW - multicomponent reactions

KW - radiochemistry

KW - radiolabeling

U2 - 10.1002/cplu.201900114

DO - 10.1002/cplu.201900114

M3 - Journal article

C2 - 31681526

AN - SCOPUS:85063866669

VL - 219

SP - 775

EP - 778

JO - ChemPlusChem

JF - ChemPlusChem

SN - 2192-6506

IS - 84

ER -

ID: 216920305