N-acylethanolamines and precursor phospholipids - Relation to cell injury

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

N-acylethanolamines and precursor phospholipids - Relation to cell injury. / Hansen, Harald S.; Moesgaard, B.; Hansen, H.H.; Petersen, G.

In: Chemistry and Physics of Lipids, Vol. 108, No. 1-2, 01.01.2000, p. 135-150.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, HS, Moesgaard, B, Hansen, HH & Petersen, G 2000, 'N-acylethanolamines and precursor phospholipids - Relation to cell injury', Chemistry and Physics of Lipids, vol. 108, no. 1-2, pp. 135-150. https://doi.org/10.1016/S0009-3084(00)00192-4

APA

Hansen, H. S., Moesgaard, B., Hansen, H. H., & Petersen, G. (2000). N-acylethanolamines and precursor phospholipids - Relation to cell injury. Chemistry and Physics of Lipids, 108(1-2), 135-150. https://doi.org/10.1016/S0009-3084(00)00192-4

Vancouver

Hansen HS, Moesgaard B, Hansen HH, Petersen G. N-acylethanolamines and precursor phospholipids - Relation to cell injury. Chemistry and Physics of Lipids. 2000 Jan 1;108(1-2):135-150. https://doi.org/10.1016/S0009-3084(00)00192-4

Author

Hansen, Harald S. ; Moesgaard, B. ; Hansen, H.H. ; Petersen, G. / N-acylethanolamines and precursor phospholipids - Relation to cell injury. In: Chemistry and Physics of Lipids. 2000 ; Vol. 108, No. 1-2. pp. 135-150.

Bibtex

@article{8fe0a5c41298418894625a745e896cdc,
title = "N-acylethanolamines and precursor phospholipids - Relation to cell injury",
abstract = "The present review focuses on the relationship between formation of N-acylethanolamine phospholipids (NAPEs) and N-acyletransferase (NAEs) catalyzed by N-acyltranferase and NAPE-hydrolyzing phospholipase D, respectively, and cell injury in tissues like brain, heart, and testis. A number of mechanisms are proposed by which these two groups of lipids may have cytoprotective properties. The mechanisms may involve activation of cannabinoid receptors, as well as non-receptor-mediated effects such as stabilization of membrane bilayers, antioxidant mechanisms, inhibition of calcium leakage from mitochondria, and direct inhibition of ceramidase. Anandamide (20:4-NAE) is formed as a minor component along with other NAEs during cell injury. Whether 20:4-NAE has a separate physiological role is at present not known, but some data suggest that 20:4-NAE may be formed, e.g. in the uterus, by a more selective mechanism without being accompanied by a vast majority of saturated and monounsaturated NAEs. (C) 2000 Elsevier Science Ireland Ltd.",
author = "Hansen, {Harald S.} and B. Moesgaard and H.H. Hansen and G. Petersen",
year = "2000",
month = jan,
day = "1",
doi = "10.1016/S0009-3084(00)00192-4",
language = "English",
volume = "108",
pages = "135--150",
journal = "Chemistry and Physics of Lipids",
issn = "0009-3084",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

RIS

TY - JOUR

T1 - N-acylethanolamines and precursor phospholipids - Relation to cell injury

AU - Hansen, Harald S.

AU - Moesgaard, B.

AU - Hansen, H.H.

AU - Petersen, G.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - The present review focuses on the relationship between formation of N-acylethanolamine phospholipids (NAPEs) and N-acyletransferase (NAEs) catalyzed by N-acyltranferase and NAPE-hydrolyzing phospholipase D, respectively, and cell injury in tissues like brain, heart, and testis. A number of mechanisms are proposed by which these two groups of lipids may have cytoprotective properties. The mechanisms may involve activation of cannabinoid receptors, as well as non-receptor-mediated effects such as stabilization of membrane bilayers, antioxidant mechanisms, inhibition of calcium leakage from mitochondria, and direct inhibition of ceramidase. Anandamide (20:4-NAE) is formed as a minor component along with other NAEs during cell injury. Whether 20:4-NAE has a separate physiological role is at present not known, but some data suggest that 20:4-NAE may be formed, e.g. in the uterus, by a more selective mechanism without being accompanied by a vast majority of saturated and monounsaturated NAEs. (C) 2000 Elsevier Science Ireland Ltd.

AB - The present review focuses on the relationship between formation of N-acylethanolamine phospholipids (NAPEs) and N-acyletransferase (NAEs) catalyzed by N-acyltranferase and NAPE-hydrolyzing phospholipase D, respectively, and cell injury in tissues like brain, heart, and testis. A number of mechanisms are proposed by which these two groups of lipids may have cytoprotective properties. The mechanisms may involve activation of cannabinoid receptors, as well as non-receptor-mediated effects such as stabilization of membrane bilayers, antioxidant mechanisms, inhibition of calcium leakage from mitochondria, and direct inhibition of ceramidase. Anandamide (20:4-NAE) is formed as a minor component along with other NAEs during cell injury. Whether 20:4-NAE has a separate physiological role is at present not known, but some data suggest that 20:4-NAE may be formed, e.g. in the uterus, by a more selective mechanism without being accompanied by a vast majority of saturated and monounsaturated NAEs. (C) 2000 Elsevier Science Ireland Ltd.

UR - http://www.scopus.com/inward/record.url?scp=0033661848&partnerID=8YFLogxK

U2 - 10.1016/S0009-3084(00)00192-4

DO - 10.1016/S0009-3084(00)00192-4

M3 - Journal article

AN - SCOPUS:0033661848

VL - 108

SP - 135

EP - 150

JO - Chemistry and Physics of Lipids

JF - Chemistry and Physics of Lipids

SN - 0009-3084

IS - 1-2

ER -

ID: 45561880