Neuropeptide Y and its involvement in chronic pain

Department of Drug Design and Pharmacology

Neuropeptide Y and its involvement in chronic pain

Research output: Contribution to journal › Review › Research › peer-review

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Neuropeptide Y and its involvement in chronic pain. / Diaz-delCastillo, Marta; Woldbye, David P D; Heegaard, Anne Marie.

In: Neuroscience, Vol. 387, 01.09.2018, p. 162-169.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Diaz-delCastillo, M, Woldbye, DPD & Heegaard, AM 2018, 'Neuropeptide Y and its involvement in chronic pain', Neuroscience, vol. 387, pp. 162-169. https://doi.org/10.1016/j.neuroscience.2017.08.050

APA

Diaz-delCastillo, M., Woldbye, D. P. D., & Heegaard, A. M. (2018). Neuropeptide Y and its involvement in chronic pain. Neuroscience, 387, 162-169. https://doi.org/10.1016/j.neuroscience.2017.08.050

Vancouver

Diaz-delCastillo M, Woldbye DPD, Heegaard AM. Neuropeptide Y and its involvement in chronic pain. Neuroscience. 2018 Sep 1;387:162-169. https://doi.org/10.1016/j.neuroscience.2017.08.050

Author

Diaz-delCastillo, Marta ; Woldbye, David P D ; Heegaard, Anne Marie. / Neuropeptide Y and its involvement in chronic pain. In: Neuroscience. 2018 ; Vol. 387. pp. 162-169.

Bibtex

@article{2dd09c60b7d7405486b2337a2c3fa34e,

title = "Neuropeptide Y and its involvement in chronic pain",

abstract = "Chronic pain is a serious condition that significantly impairs the quality of life, affecting an estimate of 1.5 billion people worldwide. Despite the physiological, emotional and financial burden of chronic pain, there is still a lack of efficient treatments. Neuropeptide Y (NPY) is a highly conserved endogenous peptide in the central and peripheral nervous systems of all mammals, which has been implicated in both pro- and antinociceptive effects. NPY is expressed in the superficial laminae of the dorsal horn of the spinal cord, where it appears to mediate its antinociceptive actions via the Y1 and Y2 receptors. Intrathecal administration of NPY in animal models of neuropathic, inflammatory or postoperative pain has been shown to cause analgesia, even though its exact mechanisms are still unclear. It remains to be seen whether these promising central antinociceptive effects of NPY can be transferred into a future treatment for chronic pain.",

keywords = "Journal Article",

author = "Marta Diaz-delCastillo and Woldbye, {David P D} and Heegaard, {Anne Marie}",

year = "2018",

month = sep,

day = "1",

doi = "10.1016/j.neuroscience.2017.08.050",

language = "English",

volume = "387",

pages = "162--169",

journal = "Neuroscience",

issn = "0306-4522",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Neuropeptide Y and its involvement in chronic pain

AU - Diaz-delCastillo, Marta

AU - Woldbye, David P D

AU - Heegaard, Anne Marie

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Chronic pain is a serious condition that significantly impairs the quality of life, affecting an estimate of 1.5 billion people worldwide. Despite the physiological, emotional and financial burden of chronic pain, there is still a lack of efficient treatments. Neuropeptide Y (NPY) is a highly conserved endogenous peptide in the central and peripheral nervous systems of all mammals, which has been implicated in both pro- and antinociceptive effects. NPY is expressed in the superficial laminae of the dorsal horn of the spinal cord, where it appears to mediate its antinociceptive actions via the Y1 and Y2 receptors. Intrathecal administration of NPY in animal models of neuropathic, inflammatory or postoperative pain has been shown to cause analgesia, even though its exact mechanisms are still unclear. It remains to be seen whether these promising central antinociceptive effects of NPY can be transferred into a future treatment for chronic pain.

AB - Chronic pain is a serious condition that significantly impairs the quality of life, affecting an estimate of 1.5 billion people worldwide. Despite the physiological, emotional and financial burden of chronic pain, there is still a lack of efficient treatments. Neuropeptide Y (NPY) is a highly conserved endogenous peptide in the central and peripheral nervous systems of all mammals, which has been implicated in both pro- and antinociceptive effects. NPY is expressed in the superficial laminae of the dorsal horn of the spinal cord, where it appears to mediate its antinociceptive actions via the Y1 and Y2 receptors. Intrathecal administration of NPY in animal models of neuropathic, inflammatory or postoperative pain has been shown to cause analgesia, even though its exact mechanisms are still unclear. It remains to be seen whether these promising central antinociceptive effects of NPY can be transferred into a future treatment for chronic pain.

KW - Journal Article

U2 - 10.1016/j.neuroscience.2017.08.050

DO - 10.1016/j.neuroscience.2017.08.050

M3 - Review

C2 - 28890052

VL - 387

SP - 162

EP - 169

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -

ID: 186910060