No effect of human serum and erythrocytes enriched in n-3 fatty acids by oral intake on Plasmodium falciparum bloodstage parasites in vitro

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No effect of human serum and erythrocytes enriched in n-3 fatty acids by oral intake on Plasmodium falciparum bloodstage parasites in vitro. / Abu-Zeid, Y.A.; Hansen, Harald S.; Jakobsen, P.H.; Bygbjerg, I.C.; Dyerberg, J.

In: European Journal of Clinical Nutrition, Vol. 47, No. 6, 01.01.1993, p. 431-436.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Abu-Zeid, YA, Hansen, HS, Jakobsen, PH, Bygbjerg, IC & Dyerberg, J 1993, 'No effect of human serum and erythrocytes enriched in n-3 fatty acids by oral intake on Plasmodium falciparum bloodstage parasites in vitro', European Journal of Clinical Nutrition, vol. 47, no. 6, pp. 431-436.

APA

Abu-Zeid, Y. A., Hansen, H. S., Jakobsen, P. H., Bygbjerg, I. C., & Dyerberg, J. (1993). No effect of human serum and erythrocytes enriched in n-3 fatty acids by oral intake on Plasmodium falciparum bloodstage parasites in vitro. European Journal of Clinical Nutrition, 47(6), 431-436.

Vancouver

Abu-Zeid YA, Hansen HS, Jakobsen PH, Bygbjerg IC, Dyerberg J. No effect of human serum and erythrocytes enriched in n-3 fatty acids by oral intake on Plasmodium falciparum bloodstage parasites in vitro. European Journal of Clinical Nutrition. 1993 Jan 1;47(6):431-436.

Author

Abu-Zeid, Y.A. ; Hansen, Harald S. ; Jakobsen, P.H. ; Bygbjerg, I.C. ; Dyerberg, J. / No effect of human serum and erythrocytes enriched in n-3 fatty acids by oral intake on Plasmodium falciparum bloodstage parasites in vitro. In: European Journal of Clinical Nutrition. 1993 ; Vol. 47, No. 6. pp. 431-436.

Bibtex

@article{08fa5e6dd9374aad82833b0cbbe9bd7d,
title = "No effect of human serum and erythrocytes enriched in n-3 fatty acids by oral intake on Plasmodium falciparum bloodstage parasites in vitro",
abstract = "To examine the effect of n-3 polyunsaturated fatty acids (n-3 PUFA) on the erythrocytic growth of Plasmodium falciparum, serum and erythrocytes were separated from blood of a healthy donor before and after he had taken fish oil capsules for 8 days. Such intake supplied an amount of eicosapentaenoic acid (EPA, 20:5n-3) of 3.5g/d and docosahexaenoic acid (DHA, 22:6n-3) of 2.5 g/d and 24 mg/d of total tocopherol. Post-intake fish oil serum (post-s) and erythrocytes (post-e) were tested in vitro for inhibitory activity against blood stages of P. falciparum compared with pre-intake serum (pre-s) and pre-intake erythrocyte (pre-e). Also the effect of EPA and arachidonic acid (AA, 20:4n-6) on the erythrocytic growth of P. falciparum was tested using in vitro assays. The results show that both post-s and post-e had no antimalarial activity on P. falciparum. No differential antimalarial effect was observed for 20:5n-3 compared with 20:4n-6, which at high concentrations (> 40 µM) had an anti-schizont-growth effect.",
author = "Y.A. Abu-Zeid and Hansen, {Harald S.} and P.H. Jakobsen and I.C. Bygbjerg and J. Dyerberg",
year = "1993",
month = jan,
day = "1",
language = "English",
volume = "47",
pages = "431--436",
journal = "European Journal of Clinical Nutrition",
issn = "0954-3007",
publisher = "nature publishing group",
number = "6",

}

RIS

TY - JOUR

T1 - No effect of human serum and erythrocytes enriched in n-3 fatty acids by oral intake on Plasmodium falciparum bloodstage parasites in vitro

AU - Abu-Zeid, Y.A.

AU - Hansen, Harald S.

AU - Jakobsen, P.H.

AU - Bygbjerg, I.C.

AU - Dyerberg, J.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - To examine the effect of n-3 polyunsaturated fatty acids (n-3 PUFA) on the erythrocytic growth of Plasmodium falciparum, serum and erythrocytes were separated from blood of a healthy donor before and after he had taken fish oil capsules for 8 days. Such intake supplied an amount of eicosapentaenoic acid (EPA, 20:5n-3) of 3.5g/d and docosahexaenoic acid (DHA, 22:6n-3) of 2.5 g/d and 24 mg/d of total tocopherol. Post-intake fish oil serum (post-s) and erythrocytes (post-e) were tested in vitro for inhibitory activity against blood stages of P. falciparum compared with pre-intake serum (pre-s) and pre-intake erythrocyte (pre-e). Also the effect of EPA and arachidonic acid (AA, 20:4n-6) on the erythrocytic growth of P. falciparum was tested using in vitro assays. The results show that both post-s and post-e had no antimalarial activity on P. falciparum. No differential antimalarial effect was observed for 20:5n-3 compared with 20:4n-6, which at high concentrations (> 40 µM) had an anti-schizont-growth effect.

AB - To examine the effect of n-3 polyunsaturated fatty acids (n-3 PUFA) on the erythrocytic growth of Plasmodium falciparum, serum and erythrocytes were separated from blood of a healthy donor before and after he had taken fish oil capsules for 8 days. Such intake supplied an amount of eicosapentaenoic acid (EPA, 20:5n-3) of 3.5g/d and docosahexaenoic acid (DHA, 22:6n-3) of 2.5 g/d and 24 mg/d of total tocopherol. Post-intake fish oil serum (post-s) and erythrocytes (post-e) were tested in vitro for inhibitory activity against blood stages of P. falciparum compared with pre-intake serum (pre-s) and pre-intake erythrocyte (pre-e). Also the effect of EPA and arachidonic acid (AA, 20:4n-6) on the erythrocytic growth of P. falciparum was tested using in vitro assays. The results show that both post-s and post-e had no antimalarial activity on P. falciparum. No differential antimalarial effect was observed for 20:5n-3 compared with 20:4n-6, which at high concentrations (> 40 µM) had an anti-schizont-growth effect.

UR - http://www.scopus.com/inward/record.url?scp=0027248559&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0027248559

VL - 47

SP - 431

EP - 436

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - 6

ER -

ID: 45562691