Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages

Research output: Contribution to journal › Journal article › Research › peer-review

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Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages. / Petersen, Ida Nymann; Kristensen, Jesper Langgaard; Herth, Matthias Manfred.

In: European Journal of Organic Chemistry, Vol. 2017, No. 3, 18.01.2017, p. 453-458.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Petersen, IN, Kristensen, JL & Herth, MM 2017, 'Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages', European Journal of Organic Chemistry, vol. 2017, no. 3, pp. 453-458. https://doi.org/10.1002/ejoc.201601448

APA

Petersen, I. N., Kristensen, J. L., & Herth, M. M. (2017). Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages. European Journal of Organic Chemistry, 2017(3), 453-458. https://doi.org/10.1002/ejoc.201601448

Vancouver

Petersen IN, Kristensen JL, Herth MM. Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages. European Journal of Organic Chemistry. 2017 Jan 18;2017(3):453-458. https://doi.org/10.1002/ejoc.201601448

Author

Petersen, Ida Nymann ; Kristensen, Jesper Langgaard ; Herth, Matthias Manfred. / Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages. In: European Journal of Organic Chemistry. 2017 ; Vol. 2017, No. 3. pp. 453-458.

Bibtex

@article{57f5f573ad304444b67f30e8487c6c42,
title = "Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages",
abstract = "The field of labeling electron-rich aryl compounds with nucleophilic [18F]fluoride has recently expanded with radiofluorination strategies that apply boronic esters or spirocyclic iodonium ylides as precursors. Herein, we present a direct comparison of these strategies by using nine chemically diverse model compounds. In general, spirocyclic iodonium ylides outperform the boronic esters.",
keywords = "Comparative studies, Isotopic labeling, Nucleophilic substitution, Spiro compounds, Ylides",
author = "Petersen, {Ida Nymann} and Kristensen, {Jesper Langgaard} and Herth, {Matthias Manfred}",
year = "2017",
month = jan,
day = "18",
doi = "10.1002/ejoc.201601448",
language = "English",
volume = "2017",
pages = "453--458",
journal = "European Journal of Organic Chemistry",
issn = "1434-193X",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "3",

}

RIS

TY - JOUR

T1 - Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages

AU - Petersen, Ida Nymann

AU - Kristensen, Jesper Langgaard

AU - Herth, Matthias Manfred

PY - 2017/1/18

Y1 - 2017/1/18

N2 - The field of labeling electron-rich aryl compounds with nucleophilic [18F]fluoride has recently expanded with radiofluorination strategies that apply boronic esters or spirocyclic iodonium ylides as precursors. Herein, we present a direct comparison of these strategies by using nine chemically diverse model compounds. In general, spirocyclic iodonium ylides outperform the boronic esters.

AB - The field of labeling electron-rich aryl compounds with nucleophilic [18F]fluoride has recently expanded with radiofluorination strategies that apply boronic esters or spirocyclic iodonium ylides as precursors. Herein, we present a direct comparison of these strategies by using nine chemically diverse model compounds. In general, spirocyclic iodonium ylides outperform the boronic esters.

KW - Comparative studies

KW - Isotopic labeling

KW - Nucleophilic substitution

KW - Spiro compounds

KW - Ylides

U2 - 10.1002/ejoc.201601448

DO - 10.1002/ejoc.201601448

M3 - Journal article

AN - SCOPUS:85010693212

VL - 2017

SP - 453

EP - 458

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

SN - 1434-193X

IS - 3

ER -

ID: 177414671